Sulfur microbial diet, genetical predisposition, and the risk of chronic kidney disease: a cohort study

Jager KJ, Kovesdy C, Langham R, Rosenberg M, Jha V, Zoccali C. A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases. Nephrol Dialysis Transplant Off Publ Eur Dialysis Transpl Assoc Eur Ren Assoc. 2019;34:1803–5. https://doi.org/10.1093/ndt/gfz174. e-pub ahead of print 2019/10/01.

Article  Google Scholar 

Karakasis P, Patoulias D, Rizzo M, Fragakis N, Mantzoros CS. Association between remnant cholesterol and chronic kidney disease: Systematic review and meta-analysis. Diabetes Obes Metab 2025. e-pub ahead of print 2025/02/14; https://doi.org/10.1111/dom.16258.

Kemp JA, Ribeiro M, Borges NA, Cardozo L, Fouque D, Mafra D. Dietary Intake and Gut Microbiome in Chronic Kidney Disease. Clin J American Soc Nephrol CJASN 2025. e-pub ahead of print 2025/03/12; https://doi.org/10.2215/cjn.0000000705

Wang X, Yang S, Li S, Zhao L, Hao Y, Qin J, et al. Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents. Gut. 2020;69:2131–42. https://doi.org/10.1136/gutjnl-2019-319766.

Article  PubMed Central  CAS  Google Scholar 

Krukowski H, Valkenburg S, Madella AM, Garssen J, van Bergenhenegouwen J, Overbeek SA, et al. Gut microbiome studies in CKD: opportunities, pitfalls and therapeutic potential. Nat Rev Nephrol. 2023;19:87–101. https://doi.org/10.1038/s41581-022-00647-z.

Article  PubMed  Google Scholar 

Nguyen LH, Cao Y, Hur J, Mehta RS, Sikavi DR, Wang Y, et al. The sulfur microbial diet is associated with increased risk of early-onset colorectal cancer precursors. Gastroenterology. 2021;161:1423–.e1424. https://doi.org/10.1053/j.gastro.2021.07.008.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wolfson SJ, Hitchings R, Peregrina K, Cohen Z, Khan S, Yilmaz T, et al. Bacterial hydrogen sulfide drives cryptic redox chemistry in gut microbial communities. Nat Metab. 2022;4:1260–70. https://doi.org/10.1038/s42255-022-00656-z.

Article  PubMed Central  CAS  Google Scholar 

Blachier F, Beaumont M, Kim E. Cysteine-derived hydrogen sulfide and gut health: a matter of endogenous or bacterial origin. Curr Opin Clin Nutr Metab Care. 2019;22:68–75. https://doi.org/10.1097/mco.0000000000000526.

Article  PubMed  CAS  Google Scholar 

Chen CJ, Cheng MC, Hsu CN, Tain YL. Sulfur-containing amino acids, hydrogen sulfide, and sulfur compounds on kidney health and disease. Metabolites 2023; 13. e-pub ahead of print 2023/06/27; https://doi.org/10.3390/metabo13060688.

Liu X, Wan X, Zhang L, Li Y, Ao Y, Zhuang P, et al. The sulfur microbial diet and increased risk of obesity: Findings from a population-based prospective cohort study. Clin Nutr. 2023;42:764–72. https://doi.org/10.1016/j.clnu.2023.03.011.

Article  PubMed  CAS  Google Scholar 

Zhang X, Liu YM, Lei F, Huang X, Liu W, Sun T, et al. Association between questionnaire-based and accelerometer-based physical activity and the incidence of chronic kidney disease using data from UK Biobank: a prospective cohort study. EClinicalMedicine. 2023;66:102323. https://doi.org/10.1016/j.eclinm.2023.102323.

Article  PubMed  PubMed Central  Google Scholar 

Zheng G, Zhang Y, Ou F, Chang Q, Ji C, Yang H, et al. Sugar types, genetic predictors of the gut microbiome, and the risk of chronic kidney disease: a prospective cohort study. Food Funct. 2024;15:4925–35. https://doi.org/10.1039/d4fo00724g.

Article  PubMed  CAS  Google Scholar 

Zhang H, Wang B, Chen C, Sun Y, Chen J, Tan X, et al. Sleep patterns, genetic susceptibility, and incident chronic kidney disease: a prospective study of 370 671 participants. Front Neurosci. 2022;16:725478. https://doi.org/10.3389/fnins.2022.725478.

Article  PubMed  Google Scholar 

Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, et al. The UK Biobank resource with deep phenotyping and genomic data. Nature. 2018;562:203–9. https://doi.org/10.1038/s41586-018-0579-z.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Peng M, Yuan S, Lu D, Ling Y, Huang X, Lyu J, et al. Dietary inflammatory index, genetic susceptibility and risk of incident dementia: a prospective cohort study from UK Biobank. J Neurol. 2024;271:1286–96. https://doi.org/10.1007/s00415-023-12065-7.

Article  PubMed  Google Scholar 

Bradbury KE, Young HJ, Guo W, Key TJ. Dietary assessment in UK Biobank: an evaluation of the performance of the touchscreen dietary questionnaire. J Nutr Sci. 2018;7:e6. https://doi.org/10.1017/jns.2017.66.

Article  Google Scholar 

Wang Y, Nguyen LH, Mehta RS, Song M, Huttenhower C, Chan AT. Association Between the Sulfur Microbial Diet and Risk of Colorectal Cancer. JAMA Netw Open. 2021;4:e2134308 https://doi.org/10.1001/jamanetworkopen.2021.34308.

Article  PubMed  PubMed Central  Google Scholar 

Sikavi DR, Nguyen LH, Haruki K, Ugai T, Ma W, Wang DD, et al. The sulfur microbial diet and risk of colorectal cancer by molecular subtypes and intratumoral microbial species in adult men. Clin Transl Gastroenterol. 2021;12:e00338. https://doi.org/10.14309/ctg.0000000000000338.

Article  PubMed  PubMed Central  Google Scholar 

Liu Z, Huang H, Ruan J, Wang Z, Xu C. The sulfur microbial diet and risk of nonalcoholic fatty liver disease: a prospective gene-diet study from the UK Biobank. Am J Clin Nutr. 2024;119:417–24. https://doi.org/10.1016/j.ajcnut.2023.11.012.

Article  PubMed  CAS  Google Scholar 

Tang R, Wang X, Li X, Ma H, Liang Z, Heianza Y, et al. Adherence to Life’s Essential 8 and incident chronic kidney disease: a prospective study of 147,988 UK Biobank participants. Am J Clin Nutr. 2023;118:804–11. https://doi.org/10.1016/j.ajcnut.2023.08.007.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tang R, Kou M, Wang X, Ma H, Li X, Heianza Y, et al. Self-reported frequency of adding salt to food and risk of incident chronic kidney disease. JAMA Netw Open. 2023;6:e2349930 https://doi.org/10.1001/jamanetworkopen.2023.49930.

Article  PubMed  Google Scholar 

Yang H, Li Z, Zhang Y, Chang Q, Jiang J, Liu Y, et al. Associations between frailty, genetic predisposition, and chronic kidney disease risk in middle-aged and older adults: a prospective cohort study. Maturitas. 2024;187:108059. https://doi.org/10.1016/j.maturitas.2024.108059.

Article  PubMed  CAS  Google Scholar 

Lipsky AM, Greenland S. Causal directed acyclic graphs. Jama. 2022;327:1083–4. https://doi.org/10.1001/jama.2022.1816.

Article  PubMed  Google Scholar 

Mansournia MA, Altman DG. Population attributable fraction. BMJ. 2018;360:k757 https://doi.org/10.1136/bmj.k757.

Article  PubMed  Google Scholar 

Sjölander A, Vansteelandt S. Doubly robust estimation of attributable fractions in survival analysis. Stat methods Med Res. 2017;26:948–69. https://doi.org/10.1177/0962280214564003.

Article  PubMed  Google Scholar 

Chen L, Lin DY, Zeng D. Attributable fraction functions for censored event times. Biometrika. 2010;97:713–26. https://doi.org/10.1093/biomet/asq023.

Article  PubMed  PubMed Central  Google Scholar 

Vanderweele TJ, Knol MJJEM. A Tutorial on Interaction. 2014; 3.

Shams-White MM, Pannucci TE, Lerman JL, Herrick KA, Zimmer M, Meyers Mathieu K, et al. Healthy Eating Index-2020: review and update process to reflect the dietary guidelines for Americans,2020-2025. J Acad Nutr Dietetics. 2023;123:1280–8. https://doi.org/10.1016/j.jand.2023.05.015.

Article  Google Scholar 

Jiang S, Xie S, Lv D, Zhang Y, Deng J, Zeng L, et al. A reduction in the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii is associated with chronic kidney disease progression. Antonie van Leeuwenhoek. 2016;109:1389–96. https://doi.org/10.1007/s10482-016-0737-y.

Article  PubMed  CAS  Google Scholar 

Mazidi M, Shekoohi N, Covic A, Mikhailidis DP, Banach MJN. Advers impact Desulfovibrio spp beneficial role Anaerostipes spp Ren Funct: Insights a Mendel randomization Anal. 2020;12:2216.

Google Scholar 

Garcia-Martinez Y, Alexandrova E, Iebba V, Ferravante C, Spinelli M, Franci G, et al. Does gut microbiota dysbiosis impact the metabolic alterations of hydrogen sulfide and lanthionine in patients with chronic kidney disease?. BMC Microbiol. 2024;24:436. https://doi.org/10.1186/s12866-024-03590-0.

Article  PubMed Central  CAS  Google Scholar 

Zheng HJ, Guo J, Wang Q, Wang L, Wang Y, Zhang F, et al. Probiotics, prebiotics, and synbiotics for the improvement of metabolic profiles in patients with chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2021;61:577–98. https://doi.org/10.1080/10408398.2020.1740645.

Article  PubMed  CAS 

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