Differentiating the abnormalities of food and monetary reward cue processing associated with overweight/obesity: an ALE meta-analysis

Phelps NH, Singleton RK, Zhou B, Heap RA, Mishra A, Bennett JE, et al. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet. 2024;403:1027–50.

Article  Google Scholar 

World Obesity Federation. World Obesity Atlas 2025. 2025. Available from: https://www.worldobesity.org/resources/resource-library/world-obesity-atlas-2025 (accessed 10 May 2025).

Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384:766–81.

Article  PubMed  PubMed Central  Google Scholar 

Grillo CA, Mulder P, Macht VA, Kaigler KF, Wilson SP, Wilson MA, et al. Dietary restriction reverses obesity-induced anhedonia. Physiol Behav. 2014;128:126–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin X, Li H. Obesity: epidemiology, pathophysiology, and therapeutics. Front Endocrinol (Lausanne). 2021;12:706978.

Article  PubMed  Google Scholar 

Davis C, Patte K, Levitan R, Reid C, Tweed S, Curtis C. From motivation to behaviour: a model of reward sensitivity, overeating, and food preferences in the risk profile for obesity. Appetite. 2007;48:12–19.

Article  PubMed  Google Scholar 

Mansur RB, Subramaniapillai M, Zuckerman H, Park C, Iacobucci M, Lee Y, et al. Effort-based decision-making is affected by overweight/obesity in major depressive disorder. J Affect Disord. 2019;256:221–7.

Article  PubMed  Google Scholar 

Nusslock R, Alloy LB. Reward processing and mood-related symptoms: An RDoC and translational neuroscience perspective. J Affect Disord. 2017;216:3–16.

Article  PubMed  PubMed Central  Google Scholar 

Meng X, Huang D, Ao H, Wang X, Gao X. Food cue recruits increased reward processing and decreased inhibitory control processing in the obese/overweight: an activation C likelihood estimation meta-analysis of fMRI studies. Obes Res Clin Pract. 2020;14:127–35.

Article  PubMed  Google Scholar 

Diekhof EK, Kaps L, Falkai P, Gruber O. The role of the human ventral striatum and the medial orbitofrontal cortex in the representation of reward magnitude—an activation likelihood estimation meta-analysis of neuroimaging studies of passive reward expectancy and outcome processing. Neuropsychologia. 2012;50:1252–66.

Article  PubMed  Google Scholar 

Sescousse G, Caldú X, Segura B, Dreher JC. Processing of primary and secondary rewards: a quantitative meta-analysis and review of human functional neuroimaging studies. Neurosci Biobehav Rev. 2013;37:681–96.

Article  PubMed  Google Scholar 

Verdejo-Roman J, Vilar-Lopez R, Navas JF, Soriano-Mas C, Verdejo-Garcia A. Brain reward system’s alterations in response to food and monetary stimuli in overweight and obese individuals. Hum Brain Mapp. 2017;38:666–77.

Article  PubMed  Google Scholar 

Gill H, Gill B, Lipsitz O, Rodrigues NB, Cha DS, El-Halabi S, et al. The impact of overweight/obesity on monetary reward processing: a systematic review. J Psychiatr Res. 2021;137:456–64.

Article  PubMed  Google Scholar 

Janssen LK, Duif I, van Loon I, Wegman J, de Vries JHM, Cools R, et al. Loss of lateral prefrontal cortex control in food-directed attention and goal-directed food choice in obesity. NeuroImage. 2017;146:148–56.

Article  PubMed  Google Scholar 

Opel N, Redlich R, Grotegerd D, Dohm K, Haupenthal C, Heindel W, et al. Enhanced neural responsiveness to reward associated with obesity in the absence of food-related stimuli. Hum Brain Mapp. 2015;36:2330–7.

Article  PubMed  PubMed Central  Google Scholar 

Mata F, Treadway M, Kwok A, Truby H, Yucel M, Stout JC, et al. Reduced willingness to expend effort for reward in obesity: link to adherence to a 3-month weight loss intervention. Obesity. 2017;25:1676–81.

Article  PubMed  Google Scholar 

Kubanek J, Snyder LH. Reward-based decision signals in parietal cortex are partially embodied. J Neurosci. 2015;35:4869–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bogdanov VB, Bogdanova OV, Dexpert S, Delgado I, Beyer H, Aubert A, et al. Reward-related brain activity and behavior are associated with peripheral ghrelin levels in obesity. Psychoneuroendocrinology. 2020;112:104520.

Article  PubMed  Google Scholar 

Kube J, Mathar D, Horstmann A, Kotz SA, Villringer A, Neumann J. Altered monetary loss processing and reinforcement-based learning in individuals with obesity. Brain Imaging Behav. 2018;12:1431–49.

Article  PubMed  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Syst Rev. 2021;10:89.

Article  PubMed  PubMed Central  Google Scholar 

Eickhoff SB, Laird AR, Grefkes C, Wang LE, Zilles K, Fox PT. Coordinate-based activation likelihood estimation meta-analysis of neuroimaging data: a random-effects approach based on empirical estimates of spatial uncertainty. Hum Brain Mapp. 2009;30:2907–26.

Article  PubMed  PubMed Central  Google Scholar 

Laird AR, Fox PM, Price CJ, Glahn DC, Uecker AM, Lancaster JL, et al. ALE meta-analysis: controlling the false discovery rate and performing statistical contrasts. Hum Brain Mapp. 2005;25:155–64.

Article  PubMed  PubMed Central  Google Scholar 

Turkeltaub PE, Eden GF, Jones KM, Zeffiro TA. Meta-analysis of the functional neuroanatomy of single-word reading: method and validation. Neuroimage. 2002;16:765–80.

Article  PubMed  Google Scholar 

Dahlberg LS, Becerra L, Borsook D, Linnman C. Brain changes after spinal cord injury, a quantitative meta-analysis and review. Neurosci Biobehav Rev. 2018;90:272–93.

Article  Google Scholar 

McCoy AN, Crowley JC, Haghighian G, Dean HL, Platt ML. Saccade reward signals in posterior cingulate cortex. Neuron. 2003;40:1031–40.

Article  CAS  PubMed  Google Scholar 

Pearson JM, Heilbronner SR, Barack DL, Hayden BY, Platt ML. Posterior cingulate cortex: adapting behavior to a changing world. Trends Cogn Sci. 2011;15:143–51.

Article  PubMed  PubMed Central  Google Scholar 

Bragulat V, Dzemidzic M, Bruno C, Cox CA, Talavage T, Considine RV, et al. Food-related odor probes of brain reward circuits during hunger: a pilot fMRI study. Obesity. 2010;18:1566–71.

Article  PubMed  Google Scholar 

Balodis IM, Kober H, Worhunsky PD, White MA, Stevens MC, Pearlson GD, et al. Monetary reward processing in obese individuals with and without binge eating disorder. Biol Psychiatry. 2013;73:877–86.

Article  PubMed  PubMed Central  Google Scholar 

Rothemund Y, Preuschhof C, Bohner G, Bauknecht H-C, Klingebiel R, Flor H, et al. Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals. NeuroImage. 2007;37:410–21.

Article  PubMed  Google Scholar 

DelParigi A, Chen K, Salbe AD, Hill JO, Wing RR, Reiman EM, et al. Persistence of abnormal neural responses to a meal in postobese individuals. Int J Obes. 2004;28:370–7.

Article  CAS  Google Scholar 

Simon JJ, Skunde M, Walther S, Bendszus M, Herzog W, Friederich H-C. Neural signature of food reward processing in bulimic-type eating disorders. Soc Cogn Affect Neurosci. 2016;11:1393–401.

Article  PubMed  PubMed Central  Google Scholar 

Fuster JM. 96Physiology of Executive functions: the perception-action cycle. In: Stuss DT, Knight RT (eds). Principles of Frontal Lobe Function. Oxford University Press, 2002.

García-García I, Jurado MÁ, Garolera M, Marqués-Iturria I, Horstmann A, Segura B, et al. Functional network centrality in obesity: a resting-state and task fMRI study. Psychiatry Res Neuroimaging. 2015;233:331–8.

Article  Google Scholar 

Liu Y, Chen H. The neural mechanisms and interventions of working memory in overweight/obese individuals. J Progress Psychol. 2023;31:1775–84.

Lopez RB, Chen P-HA, Huckins JF, Hofmann W, Kelley WM, Heatherton TF. A balance of activity in brain control and reward systems predicts self-regulatory outcomes. Soc Cogn Affect Neurosci. 2017;12:832–8.

Article  PubMed  PubMed Central  Google Scholar 

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