Abbott, R. D., Petrovitch, H., White, L. R., Masaki, K. H., Tanner, C. M., Curb, J. D., Grandinetti, A., Blanchette, P. L., Popper, J. S., & Ross, G. W. (2001). Frequency of bowel movements and the future risk of Parkinson’s disease. Neurology, 57(3), 456–462.
Article CAS PubMed Google Scholar
Adolphs, R. (2002). Neural systems for recognizing emotion. Current Opinion in Neurobiology, 12(2), 169–177.
Article CAS PubMed Google Scholar
Babmindra, V. P., Grachev, I. I., Chernysheva, M. P., Pavlenko, I. N., & Kariakin, M. G. (1979). [Morphofunctional interrelationships between the hippocampus and hypothalamus in rats] [J]. Neirofiziologiia, 11(5), 427–434.
Baker, J., & Kimpinski, K. (2020). Evidence of impaired cerebellar connectivity at rest and during autonomic maneuvers in patients with autonomic failure. Cerebellum, 19(1), 30–39.
Barbas, H. (2007). Flow of information for emotions through temporal and orbitofrontal pathways. Journal of Anatomy, 211(2), 237–249.
Article PubMed PubMed Central Google Scholar
Berlucchi, G., & Vallar, G. (2018). The history of the neurophysiology and neurology of the parietal lobe [J]. Handbook of Clinical Neurology, 151, 3–30.
Borison, H. L., & Wang, S. C. (1953). Physiology and pharmacology of vomiting. Pharmacological Reviews, 5(2), 193–230.
Article CAS PubMed Google Scholar
Braak, H., Del Tredici, K., Rüb, U., de Vos, R. A., Jansen Steur, E. N., & Braak, E. (2003). Staging of brain pathology related to sporadic parkinson’s disease [J]. Neurobiology of Aging, 24(2), 197–211.
Braak, H., Ghebremedhin, E., Rüb, U., Bratzke, H., & Del Tredici, K. (2004). Stages in the development of Parkinson’s disease-related pathology. Cell and Tissue Research, 318(1), 121–134.
Camilleri, M., Chedid, V., Ford, A. C., Haruma, K., Horowitz, M., Jones, K. L., Low, P. A., Park, S. Y., Parkman, H. P., & Stanghellini, V. (2018). Gastroparesis. Nature Reviews Disease Primers, 4(1), Article 41.
Cersosimo, M. G., Raina, G. B., Pecci, C., Pellene, A., Calandra, C. R., Gutiérrez, C., Micheli, F. E., & Benarroch, E. E. (2013). Gastrointestinal manifestations in parkinson’s disease: Prevalence and occurrence before motor symptoms. Journal of Neurology, 260(5), 1332–1338.
Article CAS PubMed Google Scholar
Chen, L. P., Dai, H. Y., Dai, Z. Z., Xu, C. T., & Wu, R. H. (2014). Anterior cingulate cortex and cerebellar hemisphere neurometabolite changes in depression treatment: A 1H magnetic resonance spectroscopy study. Psychiatry and Clinical Neurosciences, 68(5), 357–364.
Article CAS PubMed Google Scholar
Cheng, Y., Tong, Q., Yuan, Y., Song, X., Jiang, W., Wang, Y., Li, W., Li, Y., & Zhang, K. (2023). α-Synuclein induces prodromal symptoms of parkinson’s disease via activating TLR2/MyD88/NF-κB pathway in Schwann cells of vagus nerve in a rat model [J]. J Neuroinflammation, 20(1), 36.
Article CAS PubMed PubMed Central Google Scholar
Chu, C., Yu, L., Li, Y., Guo, H., Zhai, Q., Chen, W., & Tian, F. (2023). Meta-analysis of randomized controlled trials of the effects of probiotics in Parkinson’s disease. Food & Function, 14(8), 3406–3422.
Dai, Y., Mao, C., Ding, M., Ma, L., Fu, Y., Zhang, H., Li, J., & Liu, C. (2016). Correlations between constipation and the axial symptoms, related motor symptoms in Parkinson’s disease. Zhonghua Yi Xue Za Zhi, 96(5), 324–328.
Ding, Y., Ou, Y., Yan, H., Fu, X., Yan, M., Li, H., Liu, F., & Guo, W. (2022). Disrupted cerebellar-default mode network functional connectivity in major depressive disorder with gastrointestinal symptoms. Frontiers in Cellular Neuroscience, 16, Article 833592.
Article PubMed PubMed Central Google Scholar
Dzafic, I., Oestreich, L., Martin, A. K., Mowry, B., & Burianová, H. (2019). Stria terminalis, amygdala, and temporoparietal junction networks facilitate efficient emotion processing under expectations. Human Brain Mapping, 40(18), 5382–5396.
Article PubMed PubMed Central Google Scholar
Fasano, A., Visanji, N. P., Liu, L. W., Lang, A. E., & Pfeiffer, R. F. (2015). Gastrointestinal dysfunction in Parkinson’s disease. The Lancet Neurology, 14(6), 625–639.
Article CAS PubMed Google Scholar
Gao, J., Guan, X., Cen, Z., Chen, Y., Ding, X., Lou, Y., Wu, S., Wang, B., Ouyang, Z., Xuan, M., Gu, Q., Xu, X., Huang, P., Zhang, M., & Luo, W. (2019). Alteration of brain functional connectivity in Parkinson’s disease patients with dysphagia. Dysphagia, 34(4), 600–607.
Goetze, O., Nikodem, A. B., Wiezcorek, J., Banasch, M., Przuntek, H., Mueller, T., Schmidt, W. E., & Woitalla, D. (2006). Predictors of gastric emptying in Parkinson’s disease. Neurogastroenterology and Motility, 18(5), 369–375.
Article CAS PubMed Google Scholar
Grinsvall, C., Van Oudenhove, L., Dupont, P., Ryu, H. J., Ljungberg, M., Labus, J. S., Törnblom, H., Mayer, E. A., & Simrén, M. (2021). Altered structural covariance of insula, cerebellum and prefrontal cortex is associated with somatic symptom levels in irritable bowel syndrome (IBS) [J]. Brain Sci, 11(12).
Hazelton, J. L., Carneiro, F., Maito, M., Richter, F., Legaz, A., Altschuler, F., Cubillos-Pinilla, L., Chen, Y., Doherty, C. P., Baez, S., & Ibáñez, A. (2025). Neuroimaging meta-analyses reveal convergence of interoception, emotion, and social cognition across neurodegenerative diseases. Biological Psychiatry, 97(11), 1079–1090.
Article CAS PubMed Google Scholar
Ito, S. (2002). Visceral region in the rat primary somatosensory cortex identified by vagal evoked potential. Journal of Comparative Neurology, 444(1), 10–24.
Jones, J. D., Rahmani, E., Garcia, E., & Jacobs, J. P. (2020). Gastrointestinal symptoms are predictive of trajectories of cognitive functioning in de novo parkinson’s disease. Parkinsonism & Related Disorders, 72, 7–12.
Jones, J. D., Dominguez, B., Bunch, J., Uribe, C., Valenzuela, Y., & Jacobs, J. P. (2021). A bidirectional relationship between anxiety, depression and gastrointestinal symptoms in parkinson’s disease. Clinical Parkinsonism & Related Disorders, 5, Article 100104.
Kavaklioglu, T., Guadalupe, T., Zwiers, M., Marquand, A. F., Onnink, M., Shumskaya, E., Brunner, H., Fernandez, G., Fisher, S. E., & Francks, C. (2017). Structural asymmetries of the human cerebellum in relation to cerebral cortical asymmetries and handedness. Brain Structure and Function, 222(4), 1611–1623.
Ladabaum, U., Roberts, T. P., & McGonigle, D. J. (2007). Gastric fundic distension activates fronto-limbic structures but not primary somatosensory cortex: A functional magnetic resonance imaging study. Neuroimage, 34(2), 724–732.
Li, T., Le, W., & Jankovic, J. (2023). Linking the cerebellum to Parkinson disease: An update. Nature Reviews Neurology, 19(11), 645–654.
Liu, P., Li, G., Zhang, A., Yang, C., Liu, Z., Sun, N., & Kerang, Z. (2020). Brain structural and functional alterations in MDD patient with gastrointestinal symptoms: A resting-state MRI study. Journal Of Affective Disorders, 273, 95–105.
Lu, C. L., Wu, Y. T., Yeh, T. C., Chen, L. F., Chang, F. Y., Lee, S. D., Ho, L. T., & Hsieh, J. C. (2004). Neuronal correlates of gastric pain induced by fundus distension: A 3T-fMRI study. Neurogastroenterology and Motility, 16(5), 575–587.
Ma, X., Li, S., Tian, J., Jiang, G., Wen, H., Wang, T., Fang, J., Zhan, W., & Xu, Y. (2015). Altered brain spontaneous activity and connectivity network in irritable bowel syndrome patients: A resting-state fmri study. Clinical Neurophysiology, 126(6), 1190–1197.
Margolis, K. G., Cryan, J. F., & Mayer, E. A. (2021). The microbiota-gut-brain axis: From motility to mood. Gastroenterology, 160(5), 1486–1501.
Article CAS PubMed Google Scholar
Martinez-Ramirez, D., Almeida, L., Giugni, J. C., Ahmed, B., Higuchi, M. A., Little, C. S., Chapman, J. P., Mignacca, C., Wagle Shukla, A., Hess, C. W., Hegland, K. W., & Okun, M. S. (2015). Rate of aspiration pneumonia in hospitalized Parkinson’s disease patients: A cross-sectional study. BMC Neurology, 15, Article 104.
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