Zhu Z, Huangfu D. Human pluripotent stem cells: an emerging model in developmental biology. Dev Camb Engl. 2013;140(4):705–17. https://doi.org/10.1242/dev.086165.

Article  Google Scholar 

Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131(5):861–72. https://doi.org/10.1016/j.cell.2007.11.019.

Article  PubMed  Google Scholar 

Chehelgerdi M, Dehkordi FB, Chehelgerdi M, Ranjbarnejad T, et al. Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy. Mol Cancer. 2023;22:189. https://doi.org/10.1186/s12943-023-01873-0.

Article  PubMed  PubMed Central  Google Scholar 

S.355 -. FDA Modernization Act 3.0. https://www.congress.gov/bill/119th-congress/senate-bill/355

Conner DA. Mouse embryo fibroblast (MEF) feeder cell preparation. Curr Protoc Mol Biol. 2001;Unit 232. https://doi.org/Doi.10.1002/0471142727.mb2302s51. Chapter 23.

Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663–76. https://doi.org/10.1016/j.cell.2006.07.024.

Article  PubMed  Google Scholar 

Esfahani SN, Irizarry AMR, Xue X, Lee SBD, Shao Y, Fu J. Micro/nanoengineered technologies for human pluripotent stem cells maintenance and differentiation. Nano Today. 2021;41:101310. https://doi.org/10.1016/j.nantod.2021.101310.

Article  PubMed  PubMed Central  Google Scholar 

Miyazaki T, Futaki S, Hasegawa K, Suemori H. et. al. Recombinant human laminin isoforms can support the undifferentiated growth of human embryonic stem cells. Biochem Biophys Res Commun. 2008;375:27–32. https://doi.org/10.1016/j.bbrc.2008.07.111.

Article  PubMed  Google Scholar 

Miyazaki T, Futaki S, Suemori H, Taniguchi Y, Yamada M, Kawasaki M, et al. Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells. Nat Commun. 2012;3:1236. https://doi.org/10.1038/ncomms2231.

Article  PubMed  Google Scholar 

Xu C, Inokuma MS, Denham J, Golds K, Kundu P, Gold JD, et al. Feeder-free growth of undifferentiated human embryonic stem cells. Nat Biotechnol. 2001;19:971–74. https://doi.org/10.1038/nbt1001-971.

Article  PubMed  Google Scholar 

Nagaoka M, Si-Tayeb K, Akaike T, Duncan SA. Culture of human pluripotent stem cells using completely defined conditions on a Recombinant E-cadherin substratum. BMC Dev Biol. 2010;10:60. https://doi.org/10.1186/1471-213X-10-60.

Article  PubMed  PubMed Central  Google Scholar 

Rodin S, Antonsson L, Niaudet C, Simonson OE, Salmela E, Hansson EM, et al. Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment. Nat Commun. 2014;5:3195. https://doi.org/10.1038/ncomms4195.

Article  PubMed  Google Scholar 

Lu J, Hou R, Booth CJ, Yang S-H, Snyder M. Defined culture conditions of human embryonic stem cells. Proc Natl Acad Sci USA. 2006;103:5688–93. https://doi.org/10.1073/pnas.0601383103.

Article  PubMed  PubMed Central  Google Scholar 

Braam SR, Zeinstra L, Litjens S, Oostwaard DW, van den Brink S, van Laake L, et al. Recombinant vitronectin is a functionally defined substrate that supports human embryonic stem cell self-renewal via alphavbeta5 integrin. Stem Cells. 2008;26:2257–65. https://doi.org/10.1634/stemcells.2008-0291.

Article  PubMed  Google Scholar 

Villa-Diaz LG, Nandivada H, Ding J, Nogueira-de-Souza NC, Krebsbach PH, et al. Synthetic polymer coatings for long-term growth of human embryonic stem cells. Nat Biotechnol. 2010;28:581–83. https://doi.org/10.1038/nbt.1631.

Article  PubMed  PubMed Central  Google Scholar 

Irwin EF, Gupta R, Dashti DC, Healy KE. Engineered polymer-media interfaces for the long-term self-renewal of human embryonic stem cells. Biomaterials. 2011;32:6912–19. https://doi.org/10.1016/j.biomaterials.2011.05.058.

Article  PubMed  PubMed Central  Google Scholar 

Brafman DA, Chang CW, Fernandez A, Willert K, Varghese S, Chien S. Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. Biomaterials. 2010;31:9135–44. https://doi.org/10.1016/j.biomaterials.2010.08.007.

Article  PubMed  PubMed Central  Google Scholar 

Dang LTH, Feric NT, Laschinger C, Chang WY, Zhang B, Wood GA, et al. Inhibition of apoptosis in human induced pluripotent stem cells during expansion in a defined culture using angiopoietin-1 derived peptide QHREDGS. Biomaterials. 2014;35:7786–99. https://doi.org/10.1016/j.biomaterials.2014.05.018.

Article  PubMed  PubMed Central  Google Scholar 

Derda R, Li L, Orner BP, Lewis RL, Thomson JA, Kiessling LL. Defined substrates for human embryonic stem cell growth identified from surface arrays. ACS Chem Biol. 2007;2:347–55. https://doi.org/10.1021/cb700032u.

Article  PubMed  Google Scholar 

Klim JR, Li L, Wrighton PJ, Piekarczyk MS, Kiessling LL. A defined glycosaminoglycan-binding substratum for human pluripotent stem cells. Nat Methods. 2010;7:989–94. https://doi.org/10.1038/nmeth.1532.

Article  PubMed  PubMed Central  Google Scholar 

Melkoumian Z, Weber JL, Weber DM, Fadeev AG, Zhou Y, Dolley-Sonneville J, et al. Synthetic peptide-acrylate surfaces for long-term self-renewal and cardiomyocyte differentiation of human embryonic stem cells. Nat Biotechnol. 2010;28:606–10. https://doi.org/10.1038/nbt.1629.

Article  PubMed  Google Scholar 

Tannenbaum SE, Reubinoff BE. Advances in hPSC expansion towards therapeutic entities: A review. Cell Prolif. 2022;55:e13247. https://doi.org/10.1111/cpr.13247.

Article  PubMed  PubMed Central  Google Scholar 

Serra M, Correia C, Malpique R, Brito C, Jensen J, Bjorquist P al. Microencapsulation technology: A powerful tool for integrating expansion and cryopreservation of human embryonic stem cells. PLoS ONE. 2011;6(8):e23212. https://doi.org/10.1371/journal.pone.0023212.

Article  PubMed  PubMed Central  Google Scholar 

Li Z, Leung M, Hopper R, Ellenbogen R, Zhang M. Feeder-free self-renewal of human embryonic stem cells in 3D porous natural polymer scaffolds. Biomaterials. 2010;31:404–12. https://doi.org/10.1016/j.biomaterials.2009.09.070.

Article  PubMed  Google Scholar 

Chayosumrit M, Tuch B, Sidhu K. Alginate microcapsule for propagation and directed differentiation of hESCs to definitive endoderm. Biomaterials. 2010;31:505–14. https://doi.org/10.1016/j.biomaterials.2009.09.071.

Article  PubMed  Google Scholar 

Gerecht S, Burdick JA, Ferreira LS, Townsend SA, Langer R, Vunjak-Novakovic G. Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells. Proc Natl Acad Sci USA. 2007;104:11298–03. https://doi.org/10.1073/pnas.0703723104.

Article  PubMed  PubMed Central  Google Scholar 

Centeno EGZ, Cimarosti H, Bithell A. 2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling. Mol Neurodegener. 2018;13:27. https://doi.org/10.1186/s13024-018-0258-4.

Article  PubMed  PubMed Central  Google Scholar 

Chen AK-L, Chen X, Choo ABH, Reuveny S, Oh SKW. Critical microcarrier properties affecting the expansion of undifferentiated human embryonic stem cells. Stem Cell Res. 2011;7:97–111. https://doi.org/10.1016/j.scr.2011.04.007.

Article  PubMed  Google Scholar 

Chen VC, Couture SM, Ye J, Lin Z, Hua G, Huang H-IP, et al. Scalable GMP compliant suspension culture system for human ES cells. Stem Cell Res. 2012;8:388–02. https://doi.org/10.1016/j.scr.2012.02.001.

Article  PubMed  Google Scholar 

Polanco A, Kuang B, Yoon S. Bioprocess technologies that preserve the quality of iPSCs. Trends Biotechnologies. 2020;38:10. https://doi.org/10.1016/j.tibtech.2020.03.006.

Article  Google Scholar 

Borys BS, Dang T, Worden H, Larijani L, Corpuz JM, Abraham BD, et al. Robust bioprocess design and evaluation of commercial media for the serial expansion of human induced pluripotent stem cell aggregate cultures in vertical-wheel bioreactors. Stem Cell Res Ther. 2024;15:232. https://doi.org/10.1186/s13287-024-03819-9.

Article  PubMed  PubMed Central