Goud KY, Kailasa SK, Kumar V, Tsang YF, Lee SE, Gobi KV, et al. Progress on nanostructured electrochemical sensors and their recognition elements for detection of mycotoxins: a review. Biosens Bioelectron. 2018;121:205–22.

Article  CAS  PubMed  Google Scholar 

Choi J, Aarøe Mørck T, Polcher A, Knudsen LE, Joas A. Review of the state of the art of human biomonitoring for chemical substances and its application to human exposure assessment for food safety. EFSA Supporting Publications. 2015;12:724E.

Jager AV, Tonin FG, Baptista GZ, Souto PC, Oliveira CA. Assessment of aflatoxin exposure using serum and urinary biomarkers in São Paulo, Brazil: a pilot study. Int J Hyg Environ Health. 2016;219:294–300.

Article  CAS  PubMed  Google Scholar 

Heyndrickx E, Sioen I, Huybrechts B, Callebaut A, De Henauw S, De Saeger S. Human biomonitoring of multiple mycotoxins in the Belgian population: results of the BIOMYCO study. Environ Int. 2015;84:82–9.

Article  CAS  PubMed  Google Scholar 

Martins C, Vidal A, De Boevre M, De Saeger S, Nunes C, Torres D, et al. Exposure assessment of Portuguese population to multiple mycotoxins: the human biomonitoring approach. Int J Hyg Environ Health. 2019;222:913–25.

Article  CAS  PubMed  Google Scholar 

Meerpoel C, Vidal A, Andjelkovic M, De Boevre M, Tangni EK, Huybrechts B, et al. Dietary exposure assessment and risk characterization of citrinin and ochratoxin A in Belgium. Food Chem Toxicol. 2021;147:111914.

Article  CAS  PubMed  Google Scholar 

Gerding J, Cramer B, Humpf HU. Determination of mycotoxin exposure in Germany using an LC-MS/MS multibiomarker approach. Mol Nutr Food Res. 2014;58:2358–68.

Article  CAS  PubMed  Google Scholar 

Turner PC, Flannery B, Isitt C, Ali M, Pestka J. The role of biomarkers in evaluating human health concerns from fungal contaminants in food. Nutr Res Rev. 2012;25:162–79.

Article  CAS  PubMed  Google Scholar 

Warth B, Sulyok M, Fruhmann P, Berthiller F, Schuhmacher R, Hametner C, et al. Assessment of human deoxynivalenol exposure using an LC-MS/MS-based biomarker method. Toxicol Lett. 2012;211:85–90.

Article  CAS  PubMed  Google Scholar 

Santonen T, Mahiout S, Alvito P, Apel P, Bessems J, Bil W, et al. How to use human biomonitoring in chemical risk assessment: methodological aspects, recommendations, and lessons learned from HBM4EU. Int J Hyg Environ Health. 2023;249:114139.

Article  CAS  PubMed  Google Scholar 

Solfrizzo M, Gambacorta L, Visconti A. Assessment of multi-mycotoxin exposure in southern Italy by urinary multi-biomarker determination. Toxins. 2014;6:523–38.

Article  PubMed  PubMed Central  Google Scholar 

Huang Q, Jiang K, Tang Z, Fan K, Meng J, Nie D, et al. Exposure assessment of multiple mycotoxins and cumulative health risk assessment: a biomonitoring-based Study in the Yangtze River Delta, China. Toxins. 2021;13:103.

Fan K, Xu J, Jiang K, Liu X, Meng J, Di Mavungu JD, et al. Determination of multiple mycotoxins in paired plasma and urine samples to assess human exposure in Nanjing, China. Environ Pollut. 2019;248:865–73.

Article  CAS  PubMed  Google Scholar 

Turner PC, Ji BT, Shu XO, Zheng W, Chow WH, Gao YT, et al. A biomarker survey of urinary deoxynivalenol in China: the Shanghai Women’s Health Study. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011;28:1220–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Janaviciene S, Suproniene S, Kadziene G, Pavlenko R, Berzina Z, Bartkevics V. Toxigenicity of F. graminearum residing on host plants alternative to wheat as influenced by environmental conditions. Toxins. 2022;14:541.

Wallin S, Gambacorta L, Kotova N, Lemming EW, Nälsén C, Solfrizzo M, et al. Biomonitoring of concurrent mycotoxin exposure among adults in Sweden through urinary multi-biomarker analysis. Food Chem Toxicol. 2015;83:133–9.

Article  CAS  PubMed  Google Scholar 

Minglu, L. Risk Assessment of Internal and External Exposure to Mycotoxins in the Chinese Population (in Chinese) (Master’s thesis). Huazhong University of Science and Technology, Wuhan, China; 2022.

Zhao J, Han X, Xu W, Li F. Investigation of 12 mycotoxins in wheat grains from four provinces of China in 2019. Chin Chin J Food Hyg. 2021;33:765–70.

Google Scholar 

Mei M, Jiang Y, Wang Z, Liu L, Ye D, Wang Y, et al. Climatic characteristics and major meteorological events over China in 2016. Chin Meteorol Mon. 2017;45:468–76.

Google Scholar 

Deng C, Li C, Zhou S, Wang X, Xu H, Wang D, et al. Risk assessment of deoxynivalenol in high-risk areas of China by human biomonitoring using an improved high-throughput UPLC-MS/MS method. Sci Rep. 2018;8:3901.

Article  PubMed  PubMed Central  Google Scholar 

Li C, Deng C, Zhou S, Zhao Y, Wang D, Wang X, et al. High-throughput and sensitive determination of urinary zearalenone and metabolites by UPLC-MS/MS and its application to a human exposure study. Anal Bioanal Chem. 2018;410:5301–12.

Article  CAS  PubMed  Google Scholar 

Arce-López B, Lizarraga E, Flores-Flores M, Irigoyen Á, González-Peñas E. Development and validation of a methodology based on captiva EMR-lipid clean-up and LC-MS/MS analysis for the simultaneous determination of mycotoxins in human plasma. Talanta. 2020;206:120193.

Article  PubMed  Google Scholar 

Ayelign A, Woldegiorgis AZ, Adish A, De Boevre M, Heyndrickx E, De Saeger S. Assessment of aflatoxin exposure among young children in Ethiopia using urinary biomarkers. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017;34:1606–16.

Article  CAS  PubMed  Google Scholar 

Warth B, Sulyok M, Fruhmann P, Mikula H, Berthiller F, Schuhmacher R, et al. Development and validation of a rapid multi-biomarker liquid chromatography/tandem mass spectrometry method to assess human exposure to mycotoxins. Rapid Commun Mass Spectrom. 2012;26:1533–40.

Article  CAS  PubMed  Google Scholar 

EMA (European Medicines Agency). ICH M10 on bioanalytical method validation—Scientific guideline. 2011. https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-bioanalytical-method-validation_en.pdf. Accessed 17 Jan 2024.

FDA (U.S. Food and Drug Administration). Bioanalytical Method Validation Guidance for Industry. 2018. https://www.fda.gov/media/70858/download. Accessed 17 Jan 2024.

Gong YY, Shirima CP, Srey C, Martin K, Michael R. Deoxynivalenol and fumonisin exposure in children and adults in a family study in rural Tanzania. World Mycotoxin J. 2015;8:1–8.

Article  Google Scholar 

Haga M, Sakata T. Daily salt intake of healthy Japanese infants of 3-5 years based on sodium excretion in 24-hour urine. J Nutr Sci Vitaminol. 2010;56:305–10.

Article  CAS  PubMed  Google Scholar 

Gambacorta S, Solfrizzo H, Visconti A, Powers S, Oswald IP. Validation study on urinary biomarkers of exposure for aflatoxin B1, ochratoxin A, fumonisin B1, deoxynivalenol and zearalenone in piglets. World Mycotoxin J. 2013;6:299–308.

Article  CAS  Google Scholar 

Schwartz-Zimmermann HE, Binder SB, Hametner C, Miró-Abella E, Schwarz C, et al. Metabolism of nivalenol and nivalenol-3-glucoside in rats. Toxicol Lett. 2019;306:43–52.

Article  CAS  PubMed  Google Scholar 

Lee SY, Cho S, Woo SY, Hwang M, Chun HS. Risk assessment considering the bioavailability of 3-β-d-glucosides of deoxynivalenol and nivalenol through food intake in Korea. Toxins. 2023;15:460.

McKeon HP, Schepens MAA, van den Brand AD, de Jong MH, van Gelder MMHJ, Hesselink ML, et al., Assessment of mycotoxin exposure and associated risk in pregnant Dutch women: the human biomonitoring approach. Toxins. 2024;16:278.

Zhang S, Zhou S, Gong YY, Zhao Y, Wu Y. Human dietary and internal exposure to zearalenone based on a 24-hour duplicate diet and following morning urine study. Environ Int. 2020;142:105852.

Article  CAS  PubMed  Google Scholar 

Turner PC, White KL, Burley VJ, Hopton RP, Rajendram A, Fisher J, et al. A comparison of deoxynivalenol intake and urinary deoxynivalenol in UK adults. Biomarkers. 2010;15:553–62.

Article  CAS  PubMed  Google Scholar 

EPA (U.S. Environmental Protection Agency). Framework for Cumulative Risk Assessment. 2003. http://www.epa.gov/sites/default/files/2014-11/documents/frmwrk_cum_risk_assmnt.pdf. Accessed 17 Jan 2024.

Evans RM, Scholze M, Kortenkamp A. Examining the feasibility of mixture risk assessment: a case study using a tiered approach with data of 67 pesticides from the joint FAO/WHO meeting on pesticide residues (JMPR). Food Chem Toxicol. 2015;84:260–9.

Wu L, Li P, Ding X, Yue X, Bai Y. Advances in research on co-occurrence and cumulative risk assessment of mycotoxins in agricultural products. Chin J Food Saf Qual. 2018;9:3553–60.

Google Scholar 

EFSA CONTAM Panel (EFSA Panel on Contaminants in the Food Chain). Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed. EFSA J. 2017;15:e04718.

Google Scholar 

Knutsen HK, Alexander J, Barregård L, Bignami M, Brüschweiler B, et al. Risks for animal health related to the presence of zearalenone and its modified forms in feed. EFSA J. 2017;15:e04851.

PubMed  PubMed Central  Google Scholar 

EFSA CONTAM Panel (EFSA Panel on Contaminants in the Food Chain)Scientific Opinion on risks for animal and public health related to the presence of nivalenol in food and feed. EFSA J. 2013;11:3262.

Article  Google Scholar 

Altman DG. Practical Statistics for Medical Research. Chapman and Hall/CRC; 1990. p. 624.

R Core Team. R: a language and environment for statistical computing. R Foundation for Statistical Computing. 2022. https://www.R-project.org/.

Shephard GS, Burger HM, Gambacorta L, Gong YY, Krska R, et al. Multiple mycotoxin exposure determined by urinary biomarkers in rural subsistence farmers in the former Transkei, South Africa. Food Chem Toxicol. 2013;62:217–25.