Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63.

PubMed  Google Scholar 

Jajosky A, Fels Elliott DR. Esophageal cancer genetics and clinical translation. Thoracic Surg Clin. 2022;32:425–35.

Article  Google Scholar 

Jiang W, Zhang B, Xu J, Xue L, Wang L. Current status and perspectives of esophageal cancer: a comprehensive review. Cancer Commun (Lond). 2025;45:281–331.

Article  CAS  PubMed  Google Scholar 

Minacapelli CD, Bajpai M, Geng X, Cheng CL, Chouthai AA, Souza R, et al. Barrett’s metaplasia develops from cellular reprograming of esophageal squamous epithelium due to gastroesophageal reflux. Am J Physiol Gastrointest Liver Physiol. 2017;312:G615–22.

Article  PubMed  Google Scholar 

Beydoun AS, Stabenau KA, Altman KW, Johnston N. Cancer risk in Barrett’s esophagus: a clinical review. Int J Mol Sci. 2023;24:6018.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stachler MD, Camarda ND, Deitrick C, Kim A, Agoston AT, Odze RD, et al. Detection of mutations in Barrett’s esophagus before progression to high-grade dysplasia or adenocarcinoma. Gastroenterology. 2018;155:156–67.

Article  CAS  PubMed  Google Scholar 

Xu E, Gu J, Hawk ET, Wang KK, Lai M, Huang M, et al. Genome-wide methylation analysis shows similar patterns in Barrett’s esophagus and esophageal adenocarcinoma. Carcinogenesis. 2013;34:2750–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pinto R, Hauge T, Jeanmougin M, Pharo HD, Kresse SH, Honne H, et al. Targeted genetic and epigenetic profiling of esophageal adenocarcinomas and non-dysplastic Barrett’s esophagus. Clin Epigenet. 2022;14:77.

Article  CAS  Google Scholar 

Newell F, Patel K, Gartside M, Krause L, Brosda S, Aoude LG, et al. Complex structural rearrangements are present in high-grade dysplastic Barrett’s oesophagus samples. BMC Med Genom. 2019;12:31.

Article  Google Scholar 

Katz-Summercorn AC, Jammula S, Frangou A, Peneva I, O’Donovan M, Tripathi M, et al. Multi-omic cross-sectional cohort study of pre-malignant Barrett’s esophagus reveals early structural variation and retrotransposon activity. Nat Commun. 2022;13:1407.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paulson TG, Galipeau PC, Oman KM, Sanchez CA, Kuhner MK, Smith LP, et al. Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression. Nat Commun. 2022;13:2300.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luebeck J, Ng AWT, Galipeau PC, Li X, Sanchez CA, Katz-Summercorn AC, et al. Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus. Nature. 2023;616:798–805.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bao C, Tourdot RW, Brunette GJ, Stewart C, Sun L, Baba H, et al. Genomic signatures of past and present chromosomal instability in Barrett’s esophagus and early esophageal adenocarcinoma. Nat Commun. 2023;14:6203.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nones K, Waddell N, Wayte N, Patch A-M, Bailey P, Newell F, et al. Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis. Nat Commun. 2014;5:5224.

Article  CAS  PubMed  Google Scholar 

Siegel RL, Kratzer TB, Giaquinto AN, Sung H, Jemal A. Cancer statistics, 2025. CA A Cancer J Clinic. 2025;75:10–45.

Google Scholar 

Gaber CE, Sarker J, Abdelaziz AI, Okpara E, Lee TA, Klempner SJ, et al. Pathologic complete response in patients with esophageal cancer receiving neoadjuvant chemotherapy or chemoradiation: a systematic review and meta-analysis. Cancer Med. 2024;13:e7076.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dedecker H, Teuwen L-A, Vandamme T, Domen A, Prenen H. The role of immunotherapy in esophageal and gastric cancer. Clinical Colorectal Cancer. 2023;22:175–82.

Article  PubMed  Google Scholar 

Guinney J, Dienstmann R, Wang X, de Reyniès A, Schlicker A, Soneson C, et al. The consensus molecular subtypes of colorectal cancer. Nat Med. 2015;21:1350–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perou CM, Sørlie T, Eisen MB, Van De Rijn M, Jeffrey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature. 2000;406:747–52.

Article  CAS  PubMed  Google Scholar 

Cancer Genome Atlas Research Network, Analysis Working Group: Asan University, BC Cancer Agency, Brigham and Women’s Hospital, Broad Institute, Brown University, et al. Integrated genomic characterization of oesophageal carcinoma. Nature. 2017;541:169–75.

Article  Google Scholar 

Berry MF. Esophageal cancer: staging system and guidelines for staging and treatment. J Thorac Dis. 2014;6 Suppl 3:S289–297.

PubMed  Google Scholar 

Gunadasa I, Papa N, Khu YL, Brown W, Burton P, Haydon A, et al. Differential impact of post-neoadjuvant stage on overall survival for surgically treated oesophageal cancer following neoadjuvant chemotherapy or chemoradiation: a retrospective cohort study. Ann Esophagus. 2024;7:2–2.

Article  Google Scholar 

Davies AR, Gossage JA, Zylstra J, Mattsson F, Lagergren J, Maisey N, et al. Tumor stage after neoadjuvant chemotherapy determines survival after surgery for adenocarcinoma of the esophagus and esophagogastric junction. J Clin Oncol. 2014;32:2983–90.

Article  PubMed  Google Scholar 

Schwameis K, Zehetner J, Hagen JA, Oh DS, Worrell SG, Rona K, et al. Esophageal adenocarcinoma stage III: survival based on pathological response to neoadjuvant treatment. Surgical Oncol. 2017;26:522–6.

Article  Google Scholar 

Okui J, Nagashima K, Matsuda S, Sato Y, Kawakubo H, Ruhstaller T, et al. Evaluation of pathological complete response as a surrogate endpoint for overall survival in resectable oesophageal cancer: integrated analysis of individual patient data from phase III trials. Br J Surg. 2025;112:znaf131.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim SM, Park Y-Y, Park ES, Cho JY, Izzo JG, Zhang D, et al. Prognostic biomarkers for esophageal adenocarcinoma identified by analysis of tumor transcriptome. Tan P, editor. PLoS One. 2010;5:e15074.

Pinto R, Vedeld HM, Lind GE, Jeanmougin M. Unraveling epigenetic heterogeneity across gastrointestinal adenocarcinomas through a standardized analytical framework. Mol Oncol. 2024;19:1117–31.

Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA. 1999;96:8681–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hughes, Melotte LAE, de Schrijver V, de Maat J, Smit M, VTHBM, et al. The CpG island methylator phenotype: what’s in a name?. Cancer Res. 2013;73:5858–68.

Article  CAS  PubMed  Google Scholar 

Jia M, Gao X, Zhang Y, Hoffmeister M, Brenner H. Different definitions of CpG island methylator phenotype and outcomes of colorectal cancer: a systematic review. Clin Epigenet. 2016;8:25.

Article  Google Scholar 

Vedeld HM, Merok M, Jeanmougin M, Danielsen SA, Honne H, Presthus GK, et al. CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers. Intl J Cancer. 2017;141:967–76.

Article  CAS  Google Scholar 

Wang J, Deng Z, Lang X, Jiang J, Xie K, Lu S, et al. Meta-analysis of the prognostic and predictive role of the CpG Island methylator phenotype in colorectal cancer. Dis Markers. 2022;2022:4254862.

Article  PubMed  PubMed Central  Google Scholar 

Kaz AM, Wong C-J, Luo Y, Virgin JB, Washington MK, Willis JE, et al. DNA methylation profiling in Barrett’s esophagus and esophageal adenocarcinoma reveals unique methylation signatures and molecular subclasses. Epigenetics. 2011;6:1403–12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krause L, Nones K, Loffler KA, Nancarrow D, Oey H, Tang YH, et al. Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma. CARCIN. 2016;37:356–65.

Article  CAS  Google Scholar