Foxman B (2010) The epidemiology of urinary tract infection. Nat Rev Urol 7(12):653–660
Mulder M, Baan E, Verbon A, Stricker B, Verhamme K (2019) Trends of prescribing antimicrobial drugs for urinary tract infections in primary care in the Netherlands: a population-based cohort study. BMJ Open 9(5):e027221
Article PubMed PubMed Central Google Scholar
Bausch K, Stangl FP, Prieto J, Bonkat G, Kranz J (2024) Urinary infection management in frail or comorbid older individuals. Eur Urol Focus 10(5):731–733
Bono MJ, Leslie SW, Doerr C (2025) Uncomplicated urinary tract infections (Nursing). StatPearls, treasure island (FL). 2025 Jan
Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S, Coyne K, Kelleher C, Hampel C, Artibani W, Abrams P (2006) Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. Eur Urol 50(6):1306–1314 (discussion 1314–1305)
Rowe TA, Juthani-Mehta M (2013) Urinary tract infection in older adults. Aging Health 9(5):519–528
Bilsen MP, Aantjes MJ, van Andel E, Stalenhoef JE, van Nieuwkoop C, Leyten EMS, Delfos NM, Sijbom M, Numans ME, Achterberg WP, Mooijaart SP, van der Beek MT, Cobbaert CM, Conroy SP, Visser LG, Lambregts MMC (2023) Current pyuria cutoffs promote inappropriate urinary tract infection diagnosis in older women. Clin Infect Dis 76(12):2070–2076
Article PubMed PubMed Central Google Scholar
Nicolle LE, Mayhew WJ, Bryan L (1987) Prospective randomized comparison of therapy and no therapy for asymptomatic bacteriuria in institutionalized elderly women. Am J Med 83(1):27–33
Article CAS PubMed Google Scholar
Abrutyn E, Berlin J, Mossey J, Pitsakis P, Levison M, Kaye D (1996) Does treatment of asymptomatic bacteriuria in older ambulatory women reduce subsequent symptoms of urinary tract infection? J Am Geriatr Soc 44(3):293–295
Article CAS PubMed Google Scholar
Bilsen MP, Treep MM, Aantjes MJ, van Andel E, Stalenhoef JE, van Nieuwkoop C, Leyten EMS, Delfos NM, van Uhm JIM, Sijbom M, Akintola AA, Numans ME, Achterberg WP, Mooijaart SP, van der Beek MT, Cobbaert CM, Conroy SP, Visser LG, Lambregts MMC (2024) Diagnostic accuracy of urine biomarkers for urinary tract infection in older women: a case-control study. Clin Microbiol Infect 30(2):216–222
Article CAS PubMed Google Scholar
Ebrahimzadeh T, Basu U, Lutz KC, Gadhvi J, Komarovsky JV, Li Q, Zimmern PE, De Nisco NJ (2024) Inflammatory markers for improved recurrent UTI diagnosis in postmenopausal women. Life Sci Alliance. https://doi.org/10.26508/lsa.202302323
Article PubMed PubMed Central Google Scholar
Johnson JR, Owens K, Gajewski A, Kuskowski MA (2005) Bacterial characteristics in relation to clinical source of Escherichia coli isolates from women with acute cystitis or pyelonephritis and uninfected women. J Clin Microbiol 43(12):6064–6072
Article CAS PubMed PubMed Central Google Scholar
Schreiber HLT, Conover MS, Chou WC, Hibbing ME, Manson AL, Dodson KW, Hannan TJ, Roberts PL, Stapleton AE, Hooton TM, Livny J, Earl AM, Hultgren SJ (2017) Bacterial virulence phenotypes of Escherichia coli and host susceptibility determine risk for urinary tract infections. Sci Transl Med 9(382):eaaf1283
Article PubMed PubMed Central Google Scholar
Mulder M, Notermans DW, Wielders CCH, Bos J, Witteveen S, Ganesh VA, Landman F, de Haan A, Schneeberger-van der Linden C, Hendrickx APA, Dutch CPESSG (2023) OXA-48-producing uropathogenic escherichia coli sequence type 127, the Netherlands, 2015–2022. Emerg Infect Dis 29(12):2563–2565
Article CAS PubMed PubMed Central Google Scholar
Notermans DW, Schoffelen AF, Landman F, Wielders CCH, Witteveen S, Ganesh VA, van Santen-Verheuvel M, de Greeff SC, Kuijper EJ, Hendrickx APA, Dutch CPESSG (2022) A genetic cluster of OXA-244 carbapenemase-producing Escherichia coli ST38 with putative uropathogenicity factors in the Netherlands. J Antimicrob Chemother 77(11):3205–3208
Article CAS PubMed PubMed Central Google Scholar
Maldonado N, Lopez-Hernandez I, Garcia-Montaner A, Lopez-Cortes LE, Perez-Crespo PMM, Retamar-Gentil P, Sousa-Dominguez A, Goikoetxea J, Pulido-Navazo A, Labayru-Echeverria C, Natera-Kindelan C, Jover-Saenz A, Del Arco-Jimenez A, Arminanzas-Castillo C, Aller AI, Fernandez-Suarez J, Marrodan-Ciordia T, Boix-Palop L, Smithson-Amat A, Reguera-Iglesias JM, Galan-Sanchez F, Bahamonde A, Sanchez Calvo JM, Gea-Lazaro I, Perez-Camacho I, Reyes-Bertos A, Becerril-Carral B, Rodriguez-Bano J, Pascual A, Grupo PRG-SS (2024) Whole-genome characterisation of Escherichia coli isolates from patients with bacteraemia presenting with sepsis or septic shock in Spain: a multicentre cross-sectional study. Lancet Microbe 5(4):e390–e399
Article CAS PubMed Google Scholar
Bilsen MP, Treep MM, Aantjes MJ, van Andel E, Stalenhoef JE, van Nieuwkoop C, Leyten EMS, Delfos NM, van Uhm JIM, Sijbom M, Akintola AA, Numans ME, Achterberg WP, Mooijaart SP, van der Beek MT, Cobbaert CM, Conroy SP, Visser LG, Lambregts MMC (2023) Diagnostic accuracy of urine biomarkers for urinary tract infection in older women: a case-control study. Clin Microbiol Infect 30(2):216–222
European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint tables for interpretation of MICs and zone diameters, version 9.0, 2019
Landman F, Jamin C, de Haan A, Witteveen S, Bos J, van der Heide HGJ, Schouls LM, Hendrickx APA, Dutch CPEMssg (2024) Genomic surveillance of multidrug-resistant organisms based on long-read sequencing. Genome Med 16(1):137
Article CAS PubMed PubMed Central Google Scholar
Clermont typing. http://clermontyping.iame-research.center/index.php. Accessed 24 Mar 2023
Luo Y, Ma Y, Zhao Q, Wang L, Guo L, Ye L, Zhang Y, Yang J (2012) Similarity and divergence of phylogenies, antimicrobial susceptibilities, and virulence factor profiles of Escherichia coli isolates causing recurrent urinary tract infections that persist or result from reinfection. J Clin Microbiol 50(12):4002–4007
Article CAS PubMed PubMed Central Google Scholar
Bortolaia V, Kaas RS, Ruppe E, Roberts MC, Schwarz S, Cattoir V, Philippon A, Allesoe RL, Rebelo AR, Florensa AF, Fagelhauer L, Chakraborty T, Neumann B, Werner G, Bender JK, Stingl K, Nguyen M, Coppens J, Xavier BB, Malhotra-Kumar S, Westh H, Pinholt M, Anjum MF, Duggett NA, Kempf I, Nykasenoja S, Olkkola S, Wieczorek K, Amaro A, Clemente L, Mossong J, Losch S, Ragimbeau C, Lund O, Aarestrup FM (2020) Resfinder 4.0 for predictions of phenotypes from genotypes. J Antimicrob Chemother 75(12):3491–3500
Article CAS PubMed PubMed Central Google Scholar
Hidad S, van der Putten B, van Houdt R, Schneeberger C, Kuil SD (2022) Recurrent E. coli urinary tract infections in nursing homes: insight in sequence types and antibiotic resistance patterns. Antibiotics 11(11):1638
Article CAS PubMed PubMed Central Google Scholar
Forde BM, Roberts LW, Phan MD, Peters KM, Fleming BA, Russell CW, Lenherr SM, Myers JB, Barker AP, Fisher MA, Chong TM, Yin WF, Chan KG, Schembri MA, Mulvey MA, Beatson SA (2019) Population dynamics of an Escherichia coli ST131 lineage during recurrent urinary tract infection. Nat Commun 10(1):3643
Article PubMed PubMed Central Google Scholar
Hashimoto M, Ma YF, Wang ST, Chen CS, Teng CH (2021) Iron acquisition of urinary tract infection Escherichia coli involves pathogenicity in Caenorhabditis elegans. Microorganisms 9(2):310
Article CAS PubMed PubMed Central Google Scholar
Rippere-Lampe KE, Lang M, Ceri H, Olson M, Lockman HA, O’Brien AD (2001) Cytotoxic necrotizing factor type 1-positive Escherichia coli causes increased inflammation and tissue damage to the prostate in a rat prostatitis model. Infect Immun 69(10):6515–6519
Article CAS PubMed PubMed Central Google Scholar
Krawczyk B, Wityk P, Burzynska M, Majchrzak T, Markuszewski MJ (2025) Uropathogenic Escherichia coli associated with risk of urosepsis-genetic, proteomic, and metabolomic studies. Int J Mol Sci 26(12):5681
Article CAS PubMed PubMed Central Google Scholar
Guyer DM, Radulovic S, Jones FE, Mobley HL (2002) Sat, the secreted autotransporter toxin of uropathogenic Escherichia coli, is a vacuolating cytotoxin for bladder and kidney epithelial cells. Infect Immun 70(8):4539–4546
Article CAS PubMed PubMed Central Google Scholar
Marschall J, Piccirillo ML, Foxman B, Zhang L, Warren DK, Henderson JP, Program CDCPE (2013) Patient characteristics but not virulence factors discriminate between asymptomatic and symptomatic E. coli bacteriuria in the hospital. BMC Infect Dis 13:213
Comments (0)