Wang G, Qi JL, Liu XY, Ren RJ, Lin SH, Hu YS, Li HX, Xie XY, Wang JT, Li JP, Zhu YK, Gao MY, Yang JJ, Wang YR, Jing YR, Geng JL, Zhi N, Cao WW, Xu Q, Yu XP, Zhu Y, Zhou Y, Wang L, Gao C, Li B Y, Chen SD, Yuan F, Dou RH, Liu XY, Li XN, Yin YF, Chang Y, Xu G, Xin JW, Zhong YT, Li CB, Wang Y, Zhou MG, Chen XC. China alzheimer report 2024. J Diagn Concepts Pract. 2024;23(3):219–56.

CAS  Google Scholar 

Jia LF, Du YF, Chu L, Zhang ZJ, Li FY, Lyu DY, Li Y, Li Y, Zhu M, Jiao HS, Song Y, Shi YQ, Zhang H, Gong M, Wei CB, Tang Y, Fang BY, Guo DM, Wang F, Zhou AH, Chu CB, Zuo XM, Yu YY, Yuan Q, Wang W, Li F, Shi SL, Yang HY, Zhou CK, Liao ZL, Lv Y, Li Y, Kan MC, Zhao HY, Wang S, Yang SS, Li H, Liu ZL, Wang Q, Qin W, Jia JP. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in china: a cross-sectional study. Lancet Public Health. 2020;5(12):e661–71.

Article  PubMed  Google Scholar 

Zheng QY, Wang X. Alzheimer’s disease: insights into pathology, molecular mechanisms, and therapy. Protein Cell. 2025;16(2):83–120.

Article  CAS  PubMed  Google Scholar 

Passeri E, Elkhoury K, Morsink M, Broersen K, Linder M, Tamayol A, Malaplate C, Yen FT, Arab-Tehrany E. Alzheimer’s disease: treatment strategies and their limitations. Int J Mol Sci. 2022;23(22):13954.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhoopal B, Gollapelli KK, Damuka N, Miller M, Krizan I, Bansode A, Register T, Frye BM, Kim J, Mintz A, Orr M, Craft S, Whitlow C, Lockhart SN, Shively CA. Solingapuram Sai K K. Preliminary PET imaging of microtubule-based PET radioligand [(11)C]MPC-6827 in a nonhuman primate model of alzheimer’s disease. ACS Chem Neurosci. 2023;14(20):3745–51.

Article  CAS  PubMed  Google Scholar 

Ni M, Zhu ZH, Gao F, Dai LB, Lv XY, Wang Q, Zhu XX, Xie JK, Shen Y, Wang SC, Xie Q. Plasma core alzheimer’s disease biomarkers predict amyloid deposition burden by positron emission tomography in Chinese individuals with cognitive decline. ACS Chem Neurosci. 2023;14(1):170–9.

Article  CAS  PubMed  Google Scholar 

Sancesario G, Bernardini S. AD biomarker discovery in CSF and in alternative matrices. Clin Biochem. 2019; 7252–57.

Li CZ, Grajales S, Shuang SM, Dong C, Nair M. β-amyloid biomarker detection for alzheimer’s disease. J Anal Test. 2017;1(2):15.

Article  Google Scholar 

Dakterzada F, Cipriani R, López-Ortega R, Arias A, Riba-Llena I, Ruiz-Julián M, Huerto R, Tahan N, Matute C, Capetillo-Zarate E, Piñol-Ripoll G. Assessment of the correlation and diagnostic accuracy between cerebrospinal fluid and plasma alzheimer’s disease biomarkers: a comparison of the lumipulse and Simoa platforms. Int J Mol Sci. 2024;25(9):4594.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie Q, Ni M, Gao F, Dai LB, Lv XY, Zhang YF, Shi Q, Zhu XX, Xie JK, Shen Y, Wang SC. Correlation between cerebrospinal fluid core alzheimer’s disease biomarkers and β-amyloid PET in Chinese dementia population. ACS Chem Neurosci. 2022;13(10):1558–65.

Article  CAS  PubMed  Google Scholar 

Richard BC, Bayer TA, Lind SB, Shevchenko G, Bergquist J. A simplified and sensitive Immunoprecipitation mass spectrometry protocol for the analysis of amyloid-beta peptides in brain tissue. Clin Mass Spectrom. 2019; 14 Pt B83-88.

Korecka M, Shaw LM. Mass spectrometry-based methods for robust measurement of alzheimer’s disease biomarkers in biological fluids. J Neurochem. 2021;159(2):211–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arslan B, Zetterberg H, Ashton NJ. Blood-based biomarkers in alzheimer’s disease - moving towards a new era of diagnostics. Clin Chem Lab Med. 2024;62(6):1063–9.

Article  CAS  PubMed  Google Scholar 

Zeng Y, Huang Z, Liu YB, Xu TL. Printed biosensors for the detection of alzheimer’s disease based on blood biomarkers. J Anal Test. 2024;8(2):133–42.

Article  Google Scholar 

Varesi A, Carrara A, Pires VG, Floris V, Pierella E, Savioli G, Prasad S, Esposito C, Ricevuti G, Chirumbolo S, Pascale A. Blood-based biomarkers for alzheimer’s disease diagnosis and progression: an overview. Cells. 2022;11(8):1367.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Böken D, Xia ZJ, Lam JYL, Fertan E, Wu YZ, English EA, Konc J, Layburn F, Bernardes GJL, Zetterberg H, Cheetham MR, Klenerman D. Ultrasensitive protein aggregate quantification assays for neurodegenerative diseases on the Simoa platform. Anal Chem. 2025;97(1):290–9.

Article  PubMed  Google Scholar 

Lenz KD, Klosterman KE, Mukundan H, Kubicek-Sutherland JZ. Lipoprotein capture ELISA method for the sensitive detection of amphiphilic biomarkers. Anal Biochem. 2022;652:114747.

Article  CAS  PubMed  Google Scholar 

Van de Gaer O, de Haes P, Bossuyt X. Detection of Circulating anti-skin antibodies by indirect Immunofluorescence and by ELISA: a comparative systematic review and meta-analysis. Clin Chem Lab Med. 2020;58(10):1623–33.

Article  PubMed  Google Scholar 

Pierzynowska K, Morcinek-Orłowska J, Gaffke L, Jaroszewicz W, Skowron PM, Węgrzyn G. Applications of the phage display technology in molecular biology, biotechnology and medicine. Crit Rev Microbiol. 2024;50(4):450–90.

Article  CAS  PubMed  Google Scholar 

Hu JY, Bohn PW. Optical biosensing of bacteria and bacterial communities. J Anal Test. 2017;1(1):4.

Article  PubMed  PubMed Central  Google Scholar 

Zhu JG, Tao P, Chopra AK, Rao VB. Bacteriophage T4 as a protein-based, adjuvant- and needle-free, mucosal pandemic vaccine design platform. Annu Rev Virol. 2024;11(1):395–420.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hou XL, Tan LF, Xie XT, Zhang B, Wang Q, Cheng K, Fan JX, Liu TC, Liu B. Peroxisome-inspired T4 phage hybrid enzyme nanoreactors for photodynamic therapy of breast cancer. Chem Eng J. 2025;505:159138.

Article  CAS  Google Scholar 

Liu JC, Ma PX, Yu HP, Wang MY, Yin PX, Pang S, Jiao YM, Dong T, Liu AH. Discovery of a phage peptide specifically binding to the SARS-CoV-2 Spike S1 protein for the sensitive phage-based enzyme-linked chemiluminescence immunoassay of the SARS-CoV-2 antigen. Anal Chem. 2022;94(33):11591–9.

Article  CAS  PubMed  Google Scholar 

Pang S, Wang MY, Yuan JL, Yang ZH, Yu HP, Zhang HH, Dong T, Liu AH. Sensitive dual-signal ELISA based on specific phage-displayed double peptide probes with internal filtering effect to assay Monkeypox virus antigen. Anal Chem. 2024;96(24):10064–73.

Article  CAS  PubMed  Google Scholar 

Ishii T, Yanagida M. The two dispensable structural proteins (soc and hoc) of the T4 phage capsid; their purification and properties, isolation and characterization of the defective mutants, and their binding with the defective heads in vitro. J Mol Biol. 1977;109(4):487–514.

Article  CAS  PubMed  Google Scholar 

Kuhn A, Thomas JA. The beauty of bacteriophage T4 research: Lindsay W. Black and the T4 head assembly. Viruses. 2022;14(4):700.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu JG, Batra H, Ananthaswamy N, Mahalingam M, Tao P, Wu XR, Guo WZ, Fokine A, Rao VB. Design of bacteriophage T4-based artificial viral vectors for human genome remodeling. Nat Commun. 2023;14(1):2928.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tao P, Mahalingam M, Zhu JG, Moayeri M, Sha J, Lawrence WS, Leppla SH, Chopra AK. Rao V B. A bacteriophage T4 nanoparticle-based dual vaccine against anthrax and plague. mBio. 2018;9(5):e01926–18.

Article  PubMed  PubMed Central  Google Scholar 

Liu JL, Zabetakis D, Breger JC, Anderson GP, Goldman ER. Multi-enzyme assembly on T4 phage scaffold. Front Bioeng Biotechnol. 2020;8:571.

Article  PubMed  PubMed Central  Google Scholar 

Li ML, Guo PJ, Chen C, Feng HL, Zhang WP, Gu CQ, Wen GY, Rao VB, Tao P. Bacteriophage T4 vaccine platform for next-generation influenza vaccine development. Front Immunol. 2021;12:745625.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang ZJ, Lan QC, Li J, Wu JJ, Tang Y, Hu XY. Efficient streptavidin-functionalized nitrogen-doped graphene for the development of highly sensitive electrochemical immunosensor. Biosens Bioelectron. 2017;89:312–8.

Article  CAS  PubMed