Organización Panamericana de la Salud P. 2025 Paises con reporte de casos del virus Oropouche [Internet]. 2025 Feb. Available from: https://www.paho.org/es/arbo-portal/oropouche

Guu TSY, Zheng W, Tao YJ. Bunyavirus: Structure and Replication. In: Viral Molecular Machines [Internet]. Boston, MA: Springer US; 2012 [cited 2025 Jan 12]. p. 245–66. (Advances in Experimental Medicine and Biology; vol. 726). Available from: https://link.springer.com/https://doi.org/10.1007/978-1-4614-0980-9_11

Bowden TA, Bitto D, McLees A, Yeromonahos C, Elliott RM, Huiskonen JT. Orthobunyavirus Ultrastructure and the Curious Tripodal Glycoprotein Spike. PLoS Pathog. 2013;9(5):e1003374.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Eifan S, Schnettler E, Dietrich I, Kohl A, Blomström AL. Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions. Viruses. 2013;5(10):2447–68.

Article  PubMed  PubMed Central  Google Scholar 

Tilston-Lunel NL, Acrani GO, Randall RE, Elliott RM. Generation of Recombinant Oropouche Viruses Lacking the Nonstructural Protein NSm or NSs. J Virol. 2016;90(5):2616–27.

Article  PubMed Central  CAS  Google Scholar 

Elliott RM. Orthobunyaviruses: recent genetic and structural insights. Nat Rev Microbiol. 2014;12(10):673–85.

Article  PubMed  CAS  Google Scholar 

Aquino VH, Moreli ML, Moraes Figueiredo LT. Analysis of oropouche virus L protein amino acid sequence showed the presence of an additional conserved region that could harbour an important role for the polymerase activity. Adv Virol. 2003;148(1):19–28.

CAS  Google Scholar 

Murillo JL, Cabral AD, Uehara M, Da Silva VM, Dos Santos JV, Muniz JRC, et al. Nucleoprotein from the unique human infecting Orthobunyavirus of Simbu serogroup (Oropouche virus) forms higher order oligomers in complex with nucleic acids in vitro. Amino Acids. 2018;50(6):711–21.

Article  PubMed  CAS  Google Scholar 

Lozach PY, Kühbacher A, Meier R, Mancini R, Bitto D, Bouloy M, et al. DC-SIGN as a Receptor for Phleboviruses. Cell Host Microbe. 2011;10(1):75–88.

Article  PubMed  CAS  Google Scholar 

Boulant S, Stanifer M, Lozach PY. Dynamics of Virus-Receptor Interactions in Virus Binding, Signaling, and Endocytosis. Viruses. 2015;7(6):2794–815.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Geijtenbeek TBH, Engering A, Van Kooyk Y. DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J Leukoc Biol. 2002;71(6):921–31.

Article  PubMed  CAS  Google Scholar 

Dunn EF, Pritlove DC, Jin H, Elliott RM. Transcription of a Recombinant Bunyavirus RNA Template by Transiently Expressed Bunyavirus Proteins. Virology. 1995;211(1):133–43.

Article  PubMed  CAS  Google Scholar 

Obijeski JF, Bishop DH, Murphy FA, Palmer EL. Structural proteins of La Crosse virus. J Virol. 1976;19(3):985–97.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Barbosa NS, Concha JO, daSilva LLP, Crump CM, Graham SC. Oropouche Virus Glycoprotein Topology and Cellular Requirements for Glycoprotein Secretion. J Virol. 2023;97(1):e01331.

Article  PubMed  Google Scholar 

Shi X, Van Mierlo JT, French A, Elliott RM. Visualizing the Replication Cycle of Bunyamwera Orthobunyavirus Expressing Fluorescent Protein-Tagged Gc Glycoprotein. J Virol. 2010;84(17):8460–9.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Vasconcelos HB, Nunes MRT, Casseb LMN, Carvalho VL, Pinto Da Silva EV, Silva M, et al. Molecular Epidemiology of Oropouche Virus. Brazil Emerg Infect Dis. 2011;17(5):800–6.

Article  PubMed  Google Scholar 

Travassos Da Rosa JF, De Souza WM, Pinheiro FDP, Figueiredo ML, Cardoso JF, Acrani GO, et al. Oropouche Virus: Clinical, Epidemiological, and Molecular Aspects of a Neglected Orthobunyavirus. Am Soc Trop Med Hyg. 2017;96(5):1019–30.

Article  Google Scholar 

Briese T, Calisher CH, Higgs S. Viruses of the family Bunyaviridae: Are all available isolates reassortants? Virology. 2013;446(1–2):207–16.

Article  PubMed  CAS  Google Scholar 

Aguilar PV, Barrett AD, Saeed MF, Watts DM, Russell K, Guevara C, et al. Iquitos Virus: A Novel Reassortant Orthobunyavirus Associated with Human Illness in Peru. PLoS Negl Trop Dis. 2011;5(9):e1315.

Article  PubMed  PubMed Central  Google Scholar 

Ladner JT, Savji N, Lofts L, Travassos Da Rosa A, Wiley MR, Gestole MC, et al. Genomic and phylogenetic characterization of viruses included in the Manzanilla and Oropouche species complexes of the genus Orthobunyavirus, family Bunyaviridae. J Gen Virol. 2014;95(5):1055–66.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tilston-Lunel NL, Hughes J, Acrani GO, Da Silva DEA, Azevedo RSS, Rodrigues SG, et al. Genetic analysis of members of the species Oropouche virus and identification of a novel M segment sequence. J Gen Virol. 2015;96(7):1636–50.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Briese T, Bird B, Kapoor V, Nichol ST, Lipkin WI. Batai and Ngari Viruses: M Segment Reassortment and Association with Severe Febrile Disease Outbreaks in East Africa. J Virol. 2006;80(11):5627–30.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Naveca FG, Almeida TAPD, Souza V, Nascimento V, Silva D, Nascimento F, et al. Human outbreaks of a novel reassortant Oropouche virus in the Brazilian Amazon region. Nat Med 30(12):3509-21 [Internet]. 2024 Sep 18 [cited 2024 Oct 28]; Available from: https://www.nature.com/articles/s41591-024-03300-3

Morrison A, White JL, Hughes HR, Guagliardo SAJ, Velez JO, Fitzpatrick KA, et al. Oropouche Virus Disease Among U.S. Travelers — United States. MMWR Morb Mortal Wkly Rep. 2024;73(35):769–73.

Article  PubMed  PubMed Central  Google Scholar 

European Centre for Disease Prevention and Control. Oropouche virus disease cases imported into the European Union. 2024 Aug.

Desai AN, Otter A, Koopmans M, Granata G, Grobusch MP, Tunali V, et al. Oropouche virus: A re-emerging arbovirus of clinical significance. Int J Infect Dis. 2024;149:107251.

Article  PubMed  CAS  Google Scholar 

Alvarez-Falconi PP, Ríos Ruiz BA. Oropuche fever outbreak in Bagazan, San Martin, Peru: epidemiological evaluation, gastrointestinal and hemorrhagic manifestations. Rev Gastroenterol Peru. 2010;30(4):334–40.

PubMed  Google Scholar 

Sakkas H, Bozidis P, Franks A, Papadopoulou C. Oropouche Fever: A Review. Viruses. 2018;10(4):175.

Article  PubMed  PubMed Central  Google Scholar 

Zhang Z, Zhang Q, Wang T, Xu N, Lu T, Hong W, et al. Assessment of global health risk of antibiotic resistance genes. Nat Commun. 2022;13(1):1553.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bandeira AC, Pereira FM, Leal A, Santos SPO, Barbosa AC, Souza MSPL, et al. Fatal Oropouche Virus Infections in Nonendemic Region, Brazil, 2024. Emerg Infect Dis [Internet]. 2024 Nov [cited 2024 Oct 6];30(11). Available from: https://wwwnc.cdc.gov/eid/article/30/11/24-1132_article

Almeida GM, Souza JP, Mendes ND, Pontelli MC, Pinheiro NR, Nogueira GO, et al. Neural Infection by Oropouche Virus in Adult Human Brain Slices Induces an Inflammatory and Toxic Response. Front Neurosci. 2021;23(15):674576.

Article  Google Scholar 

Connors KA, Pedlow MR, Frey ZD, McGaughey JJ, Amarasinghe GK, Duprex WP, et al. Characterization of neural infection by Oropouche orthobunyavirus. bioRxiv. 2024 Oct 12; 2024. https://arxiv.org/abs/10.11.617875.

Huits R, Waggoner JJ, Castilletti C. New insights into Oropouche: expanding geographic spread, mortality, vertical transmission, and birth defects. J Travel Med. 2024;31(7):taae117.

Article  PubMed  Google Scholar 

Pastula DM, Beckham JD, Tyler KL. Oropouche Virus: An Emerging Neuroinvasive Arbovirus. Ann Neurol. 2025;97(1):28–33.

Article  Google Scholar 

De Armas Fernández JR, Peña García CE, Acosta Herrera B, Betancourt Plaza I, Gutiérrez De La Cruz Y, Resik Aguirre S, et al. Report of an unusual association of Oropouche Fever with Guillain-Barré syndrome in Cuba, 2024. Eur J Clin Microbiol Infect Dis. 2024;43(11):2233–7.

Article  PubMed  Google Scholar 

Sah R, Srivastava S, Mehta R, Khan SR, Kumar S, Satpathy P, et al. Oropouche fever fatalities and vertical transmission in South America: implications of a potential new mode of transmission. Lancet Reg Health Am. 2024;38:100896.

PubMed  PubMed Central