Imaging of metabolic dysfunction in genetic cardiomyopathies

Taegtmeyer H, Young ME, Lopaschuk GD, Abel ED, Brunengraber H, Darley-Usmar V, Des Rosiers C, Gerszten R, Glatz JF, Griffin JL et al (2016) Assessing cardiac metabolism: A scientific statement from the American heart association. Circ Res 118:1659–1701. https://doi.org/10.1161/res.0000000000000097

Article  PubMed  PubMed Central  CAS  Google Scholar 

Neely JR, Morgan HE (1974) Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle. Annu Rev Physiol 36:413–459. https://doi.org/10.1146/annurev.ph.36.030174.002213

Article  PubMed  CAS  Google Scholar 

Bing RJ (1954) The metabolism of the heart. Harvey Lect 50:27–70

PubMed  Google Scholar 

Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC (2010) Myocardial fatty acid metabolism in health and disease. Physiol Rev 90:207–258. https://doi.org/10.1152/physrev.00015.2009

Article  PubMed  CAS  Google Scholar 

Randle PJ, Garland PB, Hales CN, Newsholme EA (1963) The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1:785–789. https://doi.org/10.1016/s0140-6736(63)91500-9

Article  PubMed  CAS  Google Scholar 

Gropler RJ, Beanlands RS, Dilsizian V, Lewandowski ED, Villanueva FS, Ziadi MC (2010) Imaging myocardial metabolic remodeling. J Nucl Med 51(Suppl 1):88s–101s. https://doi.org/10.2967/jnumed.109.068197

Article  PubMed  CAS  Google Scholar 

Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED (2021) Cardiac energy metabolism in heart failure. Circ Res 128:1487–1513. https://doi.org/10.1161/CIRCRESAHA.121.318241

Article  PubMed  PubMed Central  CAS  Google Scholar 

Witjas-Paalberends ER, Güçlü A, Germans T, Knaapen P, Harms HJ, Vermeer AMC, Christiaans I, Wilde AAM, Dos Remedios C, Lammertsma AA et al (2014) Gene-specific increase in the energetic cost of contraction in hypertrophic cardiomyopathy caused by Thick filament mutations. Cardiovascular Res 103:248–257. https://doi.org/10.1093/cvr/cvu127

Bertero E, Maack C (2018) Metabolic remodelling in heart failure. Nat Rev Cardiol 15:457–470. https://doi.org/10.1038/s41569-018-0044-6

Article  PubMed  CAS  Google Scholar 

Rodolico D, Schiattarella GG, Taegtmeyer H (2023) The lure of cardiac metabolism in the diagnosis, prevention, and treatment of heart failure. JACC Heart Fail 11:637–645. https://doi.org/10.1016/j.jchf.2023.02.007

Article  PubMed  CAS  Google Scholar 

Taegtmeyer H (2000) Metabolism–the lost child of cardiology. J Am Coll Cardiol 36:1386–1388. https://doi.org/10.1016/s0735-1097(00)00870-6

Article  PubMed  CAS  Google Scholar 

Peterson LR, Gropler RJ (2020) Metabolic and molecular imaging of the diabetic cardiomyopathy. Circ Res 126:1628–1645. https://doi.org/10.1161/circresaha.120.315899

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zatcepin A, Ziegler SI (2023) Detectors in positron emission tomography. Z Med Phys 33:4–12. https://doi.org/10.1016/j.zemedi.2022.08.004

Article  PubMed  Google Scholar 

Fang W, Hsu B (2022) Myocardial blood flow quantitation with the SPECT technique: is it ready to be a substitute for PET myocardial blood flow quantitation? J Nucl Cardiol 29:3152–3154. https://doi.org/10.1007/s12350-021-02697-5

Article  PubMed  Google Scholar 

Bakermans AJ, Boekholdt SM, de Vries DK, Reckman YJ, Farag ES, de Heer P, Uthman L, Denis SW, Zuurbier CJ, Houtkooper RH et al (2021) Quantification of myocardial creatine and triglyceride content in the human heart: precision and accuracy of in vivo proton magnetic resonance spectroscopy. J Magn Reson Imaging 54:411–420. https://doi.org/10.1002/jmri.27531

Article  PubMed  PubMed Central  Google Scholar 

Abdurrachim D, Prompers JJ (2018) Evaluation of cardiac energetics by non-invasive (31)P magnetic resonance spectroscopy. Biochim Biophys Acta Mol Basis Dis 1864:1939–1948. https://doi.org/10.1016/j.bbadis.2017.11.013

Article  PubMed  CAS  Google Scholar 

Bottomley PA (1994) MR spectroscopy of the human heart: the status and the challenges. Radiology 191:593–612. https://doi.org/10.1148/radiology.191.3.8184033

Article  PubMed  CAS  Google Scholar 

Köstler H, Landschütz W, Koeppe S, Seyfarth T, Lipke C, Sandstede J, Spindler M, von Kienlin M, Hahn D, Beer M (2006) Age and gender dependence of human cardiac phosphorus metabolites determined by SLOOP 31P MR spectroscopy. Magn Reson Med 56:907–911. https://doi.org/10.1002/mrm.21027

Article  PubMed  CAS  Google Scholar 

Pluim BM, Lamb HJ, Kayser HWM, Leujes F, Beyerbacht HP, Zwinderman AH, van der Laarse A, Vliegen HW, de Roos A, van der Wall EE (1998) Functional and metabolic evaluation of the athlete’s heart by magnetic resonance imaging and dobutamine stress magnetic resonance spectroscopy. Circulation 97:666–672. https://doi.org/10.1161/01.CIR.97.7.666

Article  PubMed  CAS  Google Scholar 

Bessman SP, Geiger PJ (1981) Transport of energy in muscle: the phosphorylcreatine shuttle. Science 211:448–452. https://doi.org/10.1126/science.6450446

Article  PubMed  CAS  Google Scholar 

Spudich JA (2019) Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations. Pflugers Arch 471:701–717. https://doi.org/10.1007/s00424-019-02259-2

Article  PubMed  PubMed Central  CAS  Google Scholar 

Adhikari AS, Trivedi DV, Sarkar SS, Song D, Kooiker KB, Bernstein D, Spudich JA, Ruppel KM (2019) β-cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity. Nat Commun 10:2685. https://doi.org/10.1038/s41467-019-10555-9

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ashrafian H, Redwood C, Blair E, Watkins H (2003) Hypertrophic cardiomyopathy: a paradigm for myocardial energy depletion. Trends Genet 19:263–268. https://doi.org/10.1016/s0168-9525(03)00081-7

Article  PubMed  CAS  Google Scholar 

Ferrantini C, Belus A, Piroddi N, Scellini B, Tesi C, Poggesi C (2009) Mechanical and energetic consequences of HCM-causing mutations. J Cardiovasc Transl Res 2:441–451. https://doi.org/10.1007/s12265-009-9131-8

Article  PubMed  Google Scholar 

Witjas-Paalberends ER, Güçlü A, Germans T, Knaapen P, Harms HJ, Vermeer AM, Christiaans I, Wilde AA, Dos Remedios C, Lammertsma AA et al (2014) Gene-specific increase in the energetic cost of contraction in hypertrophic cardiomyopathy caused by Thick filament mutations. Cardiovasc Res 103:248–257. https://doi.org/10.1093/cvr/cvu127

Article  PubMed  CAS  Google Scholar 

van Driel BO, van Rossum AC, Michels M, Huurman R, van der Velden J (2019) Extra energy for hearts with a genetic defect: ENERGY trial. Neth Heart J 27:200–205. https://doi.org/10.1007/s12471-019-1239-0

Article  PubMed  PubMed Central  Google Scholar 

Timmer SAJ, Knaapen P (2012) Coronary microvascular function, myocardial metabolism, and energetics in hypertrophic cardiomyopathy: insights from positron emission tomography. Eur Heart J-Cardiovasc Imaging 14:95–101. https://doi.org/10.1093/ehjci/jes242

Article  PubMed  Google Scholar 

Armbrecht JJ, Buxton DB, Brunken RC, Phelps ME, Schelbert HR (1989) Regional myocardial oxygen consumption determined noninvasively in humans with [1-11 C]acetate and dynamic positron tomography. Circulation 80:863–872. https://doi.org/10.1161/01.cir.80.4.863

Article  PubMed  CAS  Google Scholar 

Timmer SA, Knaapen P (2013) Coronary microvascular function, myocardial metabolism, and energetics in hypertrophic cardiomyopathy: insights from positron emission tomography. Eur Heart J Cardiovasc Imaging 14:95–101. https://doi.org/10.1093/ehjci/jes242

Comments (0)

No login
gif