Curettage with grafting and open surgical resection used to be the mainstay for treating bone cysts and benign bone tumors in children; however, given the morbidity and high recurrence rates associated with open surgical techniques, minimally invasive approaches have become primary therapy in many clinical instances, which the field of interventional radiology is pioneering. This manuscript specifically addresses minimally invasive, percutaneous interventions for unicameral bone cysts, aneurysmal bone cysts, osteoid osteoma, and chondroblastoma in children.