Aguilar-Camacho M, Gómez-Sánchez CE, Cruz-Mendívil A, Guerrero-Analco JA, Monribot-Villanueva JL, Gutiérrez-Uribe JA (2023) Modeling the growth kinetics of cell suspensions of Randia echinocarpa and characterization of their bioactive phenolic compounds. Plant Cell Tiss Org Cult 155:785–796

CAS  Google Scholar 

Ali MB, Dewir YH, Hahn EJ, Paek KY (2008) Effect of carbon dioxide on antioxidant enzymes and ginsenoside production in root suspension cultures of Panax ginseng. Environ Exp Bot 63:297–304

CAS  Google Scholar 

Baque MA, Moh SH, Lee EJ, Zhong JJ, Paek KY (2012) Production of biomass and useful compounds from adventitious roots of high-value added medicinal plants using bioreactor. Biotechnol Adv 30:1255–1267

CAS  PubMed  Google Scholar 

Chen CH, Lin C, Mao CY, Jin LG, Wu SL, Zheng YF, Cui ZD, Li ZY, Zhang Y, Zhu S, Jiang H, Liu XM (2024) Natural extracts for antibacterial applications. Small 20:2306553

CAS  Google Scholar 

Chen DD, Wan JC, Lian Q, Wang JX, Wang D, Hong T, Yang YS (2022) Research progress of presticide residues in chinese herbal medicines. Chin Agr Sci Bull 38:125–135 

Cui XH, Murthy HN, Paek KY (2014) Pilot-scale culture of Hypericum perforatum L. adventitious roots in airlift bioreactors for the production of bioactive compounds. Appl Biochem Biotech 174:784–792

CAS  Google Scholar 

Devi J, Kumar A, Kumar D, Bhushan S (2022) Adventitious root cultures of Arnebia euchroma: a sustainable alternative for the production of natural pigments. Ind Crop Prod 187:115461

CAS  Google Scholar 

Duncan DB (1955) Multiple range and multiple F tests. Biometrics 11:1–42

Google Scholar 

Eh TJ, Lei P, Phyon JM, Kim HI, Xiao Y, Ma L, Li JX, Bai YJ, Ji XM, Jin GZ, Meng FJ (2024) The AaERF64-AaTPPA module participates in cold acclimatization of Actinidia arguta (Sieb. et Zucc.) Planch ex Miq. Mol Breed 44:43–79

CAS  PubMed  PubMed Central  Google Scholar 

Fan MZ, An XL, Cui XH, Jiang XL, Piao XC, Jin MY, Lian ML (2021) Production of eurycomanone and polysaccharides through adventitious root culture of Eurycoma longifolia in a bioreactor. Biochem Eng J 171:108013

CAS  Google Scholar 

Fan MZ, Jiang XL, Piao XC, Li XF, Jin MY, Lian ML (2022) Potential antibacterial and anti-biofilm effects of Anoectochilus roxburghii rhizome cultures. J Plant Biochem Biot 31:625–636

CAS  Google Scholar 

Guo LL, Sun Y, Ping XL, Liu J, Wang XM, Qin N (2022) Chemical composition and antibacterial activity of ethyl acetate extract of Astragalus membranaceus aerial parts. J Food Safety 42:e12947

CAS  Google Scholar 

Jeong JA, Wu CH, Murthy H, Hahn EJ, Paek KY (2009) Application of an airlift bioreactor system for the production of adventitious root biomass and caffeic acid derivatives of Echinacea purpurea. Biotechnol Bioproc E 14:91–98

CAS  Google Scholar 

Jiang YJ, Piao XC, Liu JS, Jiang J, Lian ZX, Kim MJ, Lian ML (2015) Bioactive compound production by adventitious root culture of Oplopanax elatus in balloon-type airlift bioreactor systemsand bioactivity property. Plant Cell Tiss Org Cult 123:413–425

CAS  Google Scholar 

Jin MY, Hao YJ, Zhang KX, Yin CR, Jiang J, Piao XC, Lian ML (2023) Fed-batch culture of Oplopanax elatus adventitious roots: establishment of a complete culture system. Biochem Eng J 194:108898

CAS  Google Scholar 

Jin MY, Piao XC, Wu XH, Fan MZ, Li XF, Yin CR, Lian ML (2020) Oplopanax elatus adventitious root production through fed-batch culture and their anti-bacterial effects. Plant Cell Tiss Org Cult 140:447–457

CAS  Google Scholar 

Kim YS, Hahn EJ, Shin CG, Yoeup PK (2005) Effects of aeration rate and sparger type on growth and ginsenoside accumulation in bioreactor cultures of ginseng adventitious root (Panax ginseng C.A. Meyer). J Plant Biot 32:111–116

Google Scholar 

Krakhmaleva IL, Molkanova OI, Orlova ND, Koroleva OV, Mitrofanova IV (2023) Plant growth regulators on the micropropagtion of Actinidia cultivars. Cienc Agrotec 47:e008923

CAS  Google Scholar 

Lee EJ, Paek KY (2012) Enhanced productivity of biomass and bioactive compounds through bioreactor cultures of Eleutherococcus koreanum Nakai adventitious roots affected by medium salt strength. Ind Crop Prod 36:460–465

CAS  Google Scholar 

Levchyk N, Skrypchenko N, Dziuba O, Gajdosova A, Liubinska A, Zaimenko N (2022) Features of morphogenesis of actinidia arguta leaf tissues at microclonal propagation. J Microb Biotec Food 12:e4667

CAS  Google Scholar 

Li Q (2018) Establishment of tissue culture and rapid propagation system of Actinidia arguta. J Liaoning Forestry Sci Technol 4:34–35+71

CAS  Google Scholar 

Liu CM, Shen Y, Yang M, Chi KM, Guo N (2022a) Hazard of staphylococcal enterotoxins in food and promising strategies for natural products against virulence. J Agric Food Chem 70:2450–2465

CAS  PubMed  Google Scholar 

Liu HC, Chan HS, Nargotra P, Shih HD, Kuo CH, Liu YC (2024) Development of Stephania tetrandra S. Moore hairy root culture process for tetrandrine production. J Biotechnol 394:11–23

CAS  PubMed  Google Scholar 

Liu YX, An XL, Xu YN, Hao YJ, Piao XC, Jin MY, Lian ML (2022b) Antibacterial and antibiofilm properties of dichloromethane fraction of extracts from adventitious roots of Eurycoma longifolia against Staphylococcus aureus. Lwt-Food Sci Technol 162:113438

CAS  Google Scholar 

Min JY, Jung HY, Kang SM, Kim YD, Kang YM, Park DJ, Prasad DT, Choi MS (2007) Production of tropane alkaloids by small-scale bubble column bioreactor cultures of Scopolia parviflora adventitious roots. Bioresource Technol 98:1748–1753

CAS  Google Scholar 

Murashige T, Skoog F (1962) A revised medium for rapid growth and bio assays with tobacco tissue cultures. Physiol Plant 15:473–497

CAS  Google Scholar 

Murthy HN, Joseph KS, Paek KY, Park SY (2023) Bioreactor configurations for adventitious root culture: recent advances toward the commercial production of specialized metabolites. Crit Rev Biotechnol 44:837–859

PubMed  Google Scholar 

Murthy HN, Kim YS, Jeong CS, Kim SJ, Zhong JJ, Paek KY (2014) Production of ginsenosides from adventitious root cultures of Panax ginseng. In: Paek KY, Murthy HN, Zhong JJ (eds) Production of biomass and bioactive compounds using bioreactor technology. Springer, Dordrecht, pp 625–651

Google Scholar 

Okla MK, Alatar AA, Al-Amri SS, Soufan WH, Ahmad A, Abdel-Maksoud MA (2021) Antibacterial and antifungal activity of the extracts of different parts of Avicennia marina (Forssk.) Vierh. Plants-Basel 10:252–265

CAS  PubMed  PubMed Central  Google Scholar 

Piao YL, Piao RZ (2011) Establishment and optimization of the tissue culture system of wild Actinidia argula. North Hortic 15:157–160

Google Scholar 

Ramonet F, Haddadi B, Harasek M (2023) Optimal design of double stage internal loop air-lift bioreactor. Energies 16:3267–3287

Google Scholar 

Scaccia N, Vaz-Moreira I, Manaia CM (2021) The risk of transmitting antibiotic resistance through endophytic bacteria. Trend Plant Sci 26:1213–1226

CAS  Google Scholar 

Shibasaki-Kitakawa N, Iizuka Y, Takahashi A, Yonemoto T (2017) A kinetic model for flavonoid production in tea cell culture. Bioproc Biosyst Eng 40:211–219

CAS  Google Scholar 

Spaggiari C, Annunziato G, Costantino G (2024) Ursolic and oleanolic acids: two natural triterpenoids targeting antibacterial multidrug tolerance and biofilm formation. Front Nat Prod 3:1456361

Google Scholar 

Student (1908) The probable error of a mean. Biometrika 6:1–25

Google Scholar 

Sun HD, Gao Y, An XL, Jiang XL, Piao XC, Jin MY, Lian ML (2021) Optimization of the culture medium of adventitious root culture to produce the flavonoids and the triterpenoids of Actinidia arguta by using an orthogonal design process. Plant Cell Tiss Org Cult 144:545–554

CAS  Google Scholar 

Wang J, Man SL, Gao WY, Zhang LM, Huang LQ (2013) Cluster analysis of ginseng tissue cultures, dynamic change of growth, total saponins, specific oxygen uptake rate in bioreactor and immuno-regulative effect of ginseng adventitious root. Ind Crop Prod 41:57–63

Google Scholar 

Wang M, Jin MY, Liu YX, Guo YQ, Li HX, Jiang J, Peak KY, Piao XC, Lian ML (2024) Adventitious root culture of Lessertia frutescens for the production of triterpenoid saponins and polysaccharides. J Biotechnol 379:87–97

CAS  PubMed  Google Scholar 

Wang M, Wang M, An D, Wu CH, Li G, Wang W, Zhang XS, Lian ML (2023) Establishment of adventitious root culture system of Cynanchum wilfordii in air-lift bioreactors for the efficient production of bioactive compounds. In Vitro Cell Dev Biol - Plant 59:216–226

CAS  Google Scholar 

Wrońska N, Szlaur M, Zawadzka K, Lisowska K (2022) The synergistic effect of triterpenoids and flavonoids—new approaches for treating bacterial infections? Molecules 27:847

PubMed  PubMed Central  Google Scholar 

Wu CH, Tang J, Jin ZX, Wang M, Liu ZQ, Huang T, Lian ML (2018) Optimizing co-culture conditions of adventitious roots of Echinacea pallida and Echinacea purpurea in air-lift bioreactor systems. Biochem Eng J 132:206–216

CAS  Google Scholar 

Yu HM, Lu XH, Wang YH, Wu SS (2015) Establishment of determination method of total triterpenoids in Mussaenda pubescens. J Liaoning Uni Tradit Chin Med 17:40–42

Google Scholar 

Zeng JY, Chen DD, Lv CL, Qin KN, Zhou Q, Pu N, Song SS, Wang XM (2022) Antimicrobial and anti-biofilm activity of Polygonum chinense L. aqueous extract against Staphylococcus aureus. Sci Rep 12:21988

CAS  PubMed  PubMed Central  Google Scholar 

Zhang HF, Teng K, Zhang H (2023) Actinidia arguta (Sieb. et Zucc.) Planch. ex Miq.: a review of phytochemistry and pharmacology. Molecules 28:7820

CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Han XN, Wang Y, Mu XF, Shi C, Li Y, Ma CP (2023b) Rapid and sensitive detection of Staphylococcus aureus via an all-in-one staggered strand exchange amplification platform. Analyst 148:1970–1977

CAS  PubMed  Google Scholar 

Zhang TH, Liu LJ, Chen QQ, Wang YF, Gao XJ, Ma XY, Yan PS (2024) Comparative assessment of in vitro xanthine oxidase and alpha-glucosidase inhibitory activities of cultured cambial meristematic cells, adventitious roots, and field-cultivated ginseng. Nutrients 16:443–454

CAS