Pilot pragmatic clinical trial of iron therapy in children with anemia of chronic kidney disease (FeTCh-CKD)

Atkinson MA, Warady BA (2018) Anemia in chronic kidney disease. Pediatr Nephrol 33:227–238

Google Scholar 

Atkinson MA, Furth SL (2011) Anemia in children with chronic kidney disease. Nat Rev Nephrol 7:635–641

CAS  Google Scholar 

Gerson A, Hwang W, Fiorenza J, Barth K, Kaskel F, Weiss L, Zelikovsky N, Fivush B, Furth S (2004) Anemia and health-related quality of life in adolescents with chronic kidney disease. Am J Kidney Dis 44:1017–1023

Google Scholar 

Surkan PJ, Charles MK, Katz J, Siegel EH, Khatry SK, LeClerq SC, Stoltzfus RJ, Tielsch JM (2015) The role of zinc and iron-folic acid supplementation on early child temperament and eating behaviors in rural Nepal: a randomized controlled trial. PLoS One 10:e0114266

Google Scholar 

Ghrayeb H, Elias M, Nashashibi J, Youssef A, Manal M, Mahagna L, Refaat M, Schwartz N, Elias A (2020) Appetite and ghrelin levels in iron deficiency anemia and the effect of parenteral iron therapy: a longitudinal study. PLoS One 15:e0234209

CAS  Google Scholar 

Zia A, Stanek J, Christian-Rancy M, Savelli S, O’Brien SH (2022) Iron deficiency and fatigue among adolescents with bleeding disorders. Am J Hematol 97:60–67

CAS  Google Scholar 

Nelson M, Bakaliou F, Trivedi A (1994) Iron-deficiency anaemia and physical performance in adolescent girls from different ethnic backgrounds. Br J Nutr 72:427–433

CAS  Google Scholar 

Lee KH, Park E, Choi HJ, Kang HG, Ha IS, Cheong HI, Park YS, Cho H, Han KH, Kim SH, Cho MH, Lee JH, Shin JI (2019) Anemia and iron deficiency in children with chronic kidney disease (CKD): data from the Know-Ped CKD Study. J Clin Med 8:152

Google Scholar 

Akchurin OM (2019) Chronic kidney disease and dietary measures to improve outcomes. Pediatr Clin North Am 66:247–267

Google Scholar 

McMurray J, Parfrey P, Adamson JW, Aljama P, Berns JS, Bohlius J, Drüeke TB, Finkelstein FO, Fishbane S, Ganz T (2012) Kidney disease: improving global outcomes (KDIGO) anemia work group. KDIGO clinical practice guideline for anemia in chronic kidney disease. Kidney Int Suppl 2:279–335

Google Scholar 

Macdougall IC, Bircher AJ, Eckardt K-U, Obrador GT, Pollock CA, Stenvinkel P, Swinkels DW, Wanner C, Weiss G, Chertow GM (2016) Iron management in chronic kidney disease: conclusions from a “Kidney Disease: Improving Global Outcomes”(KDIGO) Controversies Conference. Kidney Int 89:28–39

CAS  Google Scholar 

Sazawal S, Black RE, Ramsan M, Chwaya HM, Stoltzfus RJ, Dutta A, Dhingra U, Kabole I, Deb S, Othman MK (2006) Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet 367:133–143

CAS  Google Scholar 

Soofi S, Cousens S, Iqbal SP, Akhund T, Khan J, Ahmed I, Zaidi AKM, Bhutta ZA (2013) Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: a cluster-randomised trial. Lancet 382:29–40

CAS  Google Scholar 

Paul S, Shrestha P, Sumida K, Thomas F, Surbhi S, Naser AM, Streja E, Rhee CM, Kalantar-Zadeh K, Kovesdy CP (2023) Association of oral iron replacement therapy with kidney failure and mortality in CKD patients. Clin Kidney J 16:2082–2090

CAS  Google Scholar 

Gutiérrez OM (2021) Treatment of iron deficiency anemia in CKD and end-stage kidney disease. Kidney Int Rep 6:2261–2269

Google Scholar 

Meza K, Biswas S, Talmor C, Baqai K, Samsonov D, Solomon S, Akchurin O (2024) Response to oral iron therapy in children with anemia of chronic kidney disease. Pediatr Nephrol 39:233–242

Google Scholar 

Akchurin O, Molino AR, Schneider MF, Atkinson MA, Warady BA, Furth SL (2023) Longitudinal relationship between anemia and statural growth impairment in children and adolescents with nonglomerular CKD: findings from the chronic kidney disease in children (CKiD) study. Am J Kidney Dis 81:457–65.e1

Google Scholar 

Kliger AS, Foley RN, Goldfarb DS, Goldstein SL, Johansen K, Singh A, Szczech L (2013) KDOQI US commentary on the 2012 KDIGO clinical practice guideline for anemia in CKD. Am J Kidney Dis 62:849–859

Google Scholar 

Irwin DE, Gross HE, Stucky BD, Thissen D, DeWitt EM, Lai JS, Amtmann D, Khastou L, Varni JW, DeWalt DA (2012) Development of six PROMIS pediatrics proxy-report item banks. Health Qual Life Outcomes 10:22

Google Scholar 

Tucker CA, Bevans KB, Teneralli RE, Smith AW, Bowles HR, Forrest CB (2014) Self-reported pediatric measures of physical activity, sedentary behavior, and strength impact for PROMIS: conceptual framework. Pediatr Phys Ther 26:376–384

Google Scholar 

Tucker CA, Bevans KB, Teneralli RE, Smith AW, Bowles HR, Forrest CB (2014) Self-reported pediatric measures of physical activity, sedentary behavior, and strength impact for PROMIS: item development. Pediatr Phys Ther 26:385–392

Google Scholar 

Akchurin OM, Schneider MF, Mulqueen L, Brooks ER, Langman CB, Greenbaum LA, Furth SL, Moxey-Mims M, Warady BA, Kaskel FJ, Skversky AL (2014) Medication adherence and growth in children with CKD. Clin J Am Soc Nephrol 9:1519–1525

Google Scholar 

Babitt JL, Eisenga MF, Haase VH, Kshirsagar AV, Levin A, Locatelli F, Małyszko J, Swinkels DW, Tarng D-C, Cheung M (2021) Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference. Kidney Int 99:1280–1295

Google Scholar 

Tolkien Z, Stecher L, Mander AP, Pereira DIA, Powell JJ (2015) Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis. PLoS One 10:e0117383

Google Scholar 

Kortman GAM, Reijnders D, Swinkels DW (2017) Oral iron supplementation: Potential implications for the gut microbiome and metabolome in patients with CKD. Hemodial Int 21:S28–S36

Google Scholar 

Dewey KG, Cohen RJ, Lönnerdal B, Domellöf M, Rivera LL, Hernell O (2002) Iron supplementation affects growth and morbidity of breast-fed infants: results of a randomized trial in Sweden and Honduras. J Nutr 132:3249–3255

CAS  Google Scholar 

Perng W, Mora-Plazas M, Marin C, Villamor E (2013) Iron status and linear growth: a prospective study in school-age children. Eur J Clin Nutr 67:646–651

CAS  Google Scholar 

Patino E, Doty SB, Bhatia D, Meza K, Zhu YS, Rivella S, Choi ME, Akchurin O (2020) Carbonyl iron and iron dextran therapies cause adverse effects on bone health in juveniles with chronic kidney disease. Kidney Int 98:1210–1224

CAS  Google Scholar 

Oboshi M, Naito Y, Sawada H, Iwasaku T, Okuhara Y, Eguchi A, Hirotani S, Mano T, Tsujino T, Masuyama T (2016) Attenuation of hypertension and renal damage in renovascular hypertensive rats by iron restriction. Hypertens Res 39:832–839

CAS  Google Scholar 

Hanudel MR, Chua K, Rappaport M, Gabayan V, Valore E, Goltzman D, Ganz T, Nemeth E, Salusky IB (2016) Effects of dietary iron intake and chronic kidney disease on fibroblast growth factor 23 metabolism in wild-type and hepcidin knockout mice. Am J Physiol Renal Physiol 311:F1369–F1377

Google Scholar 

van Swelm RPL, Beurskens S, Dijkman H, Wiegerinck ETG, Roelofs R, Thévenod F, van der Vlag J, Wetzels JFM, Swinkels DW, Smeets B (2022) Kidney tubule iron loading in experimental focal segmental glomerulosclerosis. Sci Rep 12:1199

Google Scholar 

Feng Y, Jia L, Ma W, Tian C, Du H (2023) Iron chelator deferoxamine alleviates progression of diabetic nephropathy by relieving inflammation and fibrosis in rats. Biomolecules 13:1266

CAS  Google Scholar 

Rajapurkar MM, Hegde U, Bhattacharya A, Alam MG, Shah SV (2013) Effect of deferiprone, an oral iron chelator, in diabetic and non-diabetic glomerular disease. Toxicol Mech Methods 23:5–10

CAS  Google Scholar 

Guan Y, Liang X, Ma Z, Hu H, Liu H, Miao Z, Linkermann A, Hellwege JN, Voight BF, Susztak K (2021) A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis. Nat Commun 12:5078

CAS  Google Scholar 

Arsiwala T, Afroz N, Kordy K, Naujoks C, Patalano F (2021) Measuring what matters for children: a systematic review of frequently used pediatric generic PRO instruments. Ther Innov Regul Sci 55:1082–1095

Google Scholar 

Prochaska MT, Huisingh-Scheetz M, Meltzer D (2022) Sex differences in fatigue and symptoms of anemia in relation to hemoglobin level in hospitalized patients. Ann Hematol 101:1873–1875

CAS  Google Scholar 

Farag YMK, Blasco-Colmenares E, Zhao D, Sanon M, Guallar E, Finkelstein FO (2023) Effect of anemia on physical function and physical activity in CKD: The National Health and Nutrition Examination Survey, 1999–2016. Kidney360 4:e1212

Odden MC, Whooley MA, Shlipak MG (2004) Association of chronic kidney disease and anemia with physical capacity: the heart and soul study. J Am Soc Nephrol 15:2908–2915

Google Scholar 

Carlson J, Gerson AC, Matheson MB, Manne S, Warady BA, Hooper SR, Lande M, Harshman LA, Johnson RJ, Shinnar S (2020) A longitudinal analysis of the effect of anemia on health-related quality of life in children with mild-to-moderate chronic kidney disease. Pediatr Nephrol 35:1659–1667

Google Scholar 

Penninx BWJH, Pahor M, Cesari M, Corsi AM, Woodman RC, Bandinelli S, Guralnik JM, Ferrucci L (2004) Anemia is associated with disability and decreased physical performance and muscle strength in the elderly. J Am Geriatr Soc 52:719–724

Google Scholar 

Vinke JSJ, Wouters HJCM, Stam SP, Douwes RM, Post A, Gomes‐Neto AW, van der Klauw MM, Berger SP, Bakker SJL; TransplantLines Investigators; De Borst MH, Eisenga MF (2022) Decreased haemoglobin levels are associated with lower muscle mass and strength in kidney transplant recipients. J Cachexia Sarcopenia Muscle 13:2044–2053

Sypes EE, Parkin PC, Birken CS, Carsley S, MacArthur C, Maguire JL, Borkhoff CM, Aglipay M, Anderson LN, Dai DWH (2019) Higher body mass index is associated with iron deficiency in children 1 to 3 years of age. J Pediatr 207:198–204

CAS  Google Scholar 

Borgna-Pignatti C, Zanella S (2016) Pica as a manifestation of iron deficiency. Expert Rev Hematol 9:1075–1080

CAS  Google Scholar 

Ganesan PR, Vasauskas AA (2023) The association between pica and iron-deficiency anemia: a scoping review. Cureus 15:e37904

Google Scholar 

Kucuk N, Orbak Z, Karakelloglu C, Akcay F (2019) The effect of therapy on plasma ghrelin and leptin levels, and appetite in children with iron deficiency anemia. J Pediatr Endocrinol Metab 32:275–280

CAS  Google Scholar 

Powers JM, Buchanan GR, Adix L, Zhang S, Gao A, McCavit TL (2017) Effect of low-dose ferrous sulfate vs iron polysaccharide complex on hemoglobin concentration in young children with nutritional iron-deficiency anemia: a randomized clinical trial. JAMA 317:2297–2304

CAS  Google Scholar 

Macdougall IC, Bock AH, Carrera F, Eckardt K-U, Gaillard C, Van Wyck D, Meier Y, Larroque S, Perrin A, Roger SD (2017) Erythropoietic response to oral iron in patients with nondialysis-dependent chronic kidney disease in the FIND-CKD trial. Clin Nephrol 88:301

CAS  Google Scholar 

Akchurin O, Patino E, Dalal V, Meza K, Bhatia D, Brovender S, Zhu YS, Cunningham-Rundles S, Perelstein E, Kumar J, Rivella S, Choi ME (2019) Interleukin-6 contributes to the development of anemia in juvenile CKD. Kidney Int Rep 4:470–483

Google Scholar 

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