Vertigo and dizziness in genetic neurodevelopmental disorders: an international cross-sectional study

American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders: DSM-5. American Psychiatric Publishing Inc

Book  Google Scholar 

Francés L, Quintero J, Fernández A et al (2022) Current state of knowledge on the prevalence of neurodevelopmental disorders in childhood according to the DSM-5: a systematic review in accordance with the PRISMA criteria. Child Adolesc Psychiatry Ment Health 16:27. https://doi.org/10.1186/s13034-022-00462-1

Article  PubMed  PubMed Central  Google Scholar 

Vissers LELM, Gilissen C, Veltman JA (2016) Genetic studies in intellectual disability and related disorders. Nat Rev Genet 17:9–18. https://doi.org/10.1038/nrg3999

Article  PubMed  Google Scholar 

Parenti I, Rabaneda LG, Schoen H, Novarino G (2020) Neurodevelopmental disorders: from genetics to functional pathways. Trends Neurosci 43:608–621. https://doi.org/10.1016/j.tins.2020.05.004

Article  PubMed  Google Scholar 

Lopez C (2016) The vestibular system: balancing more than just the body. Curr Opin Neurol 29:74–83. https://doi.org/10.1097/WCO.0000000000000286

Article  PubMed  Google Scholar 

Verheij E, Elden L, Crowley TB et al (2018) Anatomic malformations of the middle and inner ear in 22q11.2 deletion syndrome: case series and literature review. AJNR Am J Neuroradiol 39:928–934. https://doi.org/10.3174/ajnr.A5588

Article  PubMed  PubMed Central  Google Scholar 

Willaert A, Van Eynde C, Verhaert N et al (2019) Vestibular dysfunction is a manifestation of 22q11.2 deletion syndrome. Am J Med Genet A 179:448–454. https://doi.org/10.1002/ajmg.a.7

Article  PubMed  Google Scholar 

Van Hecke R, Danneels M, Dhooge I et al (2019) Vestibular function in children with neurodevelopmental disorders: a systematic review. J Autism Dev Disord 49:3328–3350. https://doi.org/10.1007/s10803-019-04059-0

Article  PubMed  Google Scholar 

Bigelow RT, Semenov YR, Hoffman HJ, Agrawal Y (2020) Association between vertigo, cognitive and psychiatric conditions in US children: 2012 National Health Interview Survey. Int J Pediatr Otorhinolaryngol 130:109802. https://doi.org/10.1016/j.ijporl.2019.109802

Article  PubMed  Google Scholar 

Rine RM, Wiener-Vacher S (2013) Evaluation and treatment of vestibular dysfunction in children. NeuroRehabilitation 32:507–518. https://doi.org/10.3233/NRE-130873

Article  PubMed  Google Scholar 

Antoine MW, Hübner CA, Arezzo JC, Hébert JM (2013) A causative link between inner ear defects and long-term striatal dysfunction. Science 341:1120–1123. https://doi.org/10.1126/science.1240405

Article  PubMed  PubMed Central  Google Scholar 

Antoine MW, Vijayakumar S, McKeehan N et al (2017) The severity of vestibular dysfunction in deafness as a determinant of comorbid hyperactivity or anxiety. J Neurosci Off J Soc Neurosci 37:5144–5154. https://doi.org/10.1523/JNEUROSCI.3545-16.2017

Article  Google Scholar 

Le Gall A, Hilber P, Chesneau C et al (2019) The critical role of vestibular graviception during cognitive-motor development. Behav Brain Res 372:112040. https://doi.org/10.1016/j.bbr.2019.112040

Article  PubMed  Google Scholar 

Bucci MP, Moscoso A, Acquaviva E et al (2024) Eye movements and postural control in children; biomarkers of neurodevelopmental disorders: evidences toward new forms of therapeutic intervention? J Pediatr Neuropsychol 10:231–242. https://doi.org/10.1007/s40817-024-00172-w

Article  Google Scholar 

Burger P, Colin F, Strehle A et al (2023) GenIDA: an international participatory database to gain knowledge on health issues related to genetic forms of neurodevelopmental disorders. J Neural Transm Vienna Austria 1996 130:459–471. https://doi.org/10.1007/s00702-022-02569-3

Article  Google Scholar 

Colin F, Burger P, Mazzucotelli T et al (2023) GenIDA, a participatory patient registry for genetic forms of intellectual disability provides detailed caregiver-reported information on 237 individuals with Koolen-de Vries syndrome. Genet Med Open 1:100817. https://doi.org/10.1016/j.gimo.2023.100817

Article  PubMed  PubMed Central  Google Scholar 

Li C-M, Hoffman HJ, Ward BK et al (2016) Epidemiology of dizziness and balance problems in children in the united states: a population-based study. J Pediatr 171(240–247):e1-3. https://doi.org/10.1016/j.jpeds.2015.12.002

Article  Google Scholar 

von Elm E, Altman DG, Egger M et al (2007) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370:1453–1457. https://doi.org/10.1016/S0140-6736(07)61602-X

Article  Google Scholar 

Neuhauser HK, von Brevern M, Radtke A et al (2005) Epidemiology of vestibular vertigo: a neurotologic survey of the general population. Neurology 65:898–904. https://doi.org/10.1212/01.wnl.0000175987.59991.3d

Article  PubMed  Google Scholar 

Hülse R, Biesdorf A, Hörmann K et al (2019) Peripheral vestibular disorders: an epidemiologic survey in 70 million individuals. Otol Neurotol 40:88–95. https://doi.org/10.1097/MAO.0000000000002013

Article  PubMed  Google Scholar 

Wiener-Vacher SR, Quarez J, Priol AL (2018) Epidemiology of vestibular impairments in a pediatric population. Semin Hear 39:229–242. https://doi.org/10.1055/s-0038-1666815

Article  PubMed  PubMed Central  Google Scholar 

Smith PF, Agrawal Y, Darlington CL (2019) Sexual dimorphism in vestibular function and dysfunction. J Neurophysiol 121:2379–2391. https://doi.org/10.1152/jn.00074.2019

Article  PubMed  Google Scholar 

Brandt T, Dieterich M (2020) “Excess anxiety” and “less anxiety”: both depend on vestibular function. Curr Opin Neurol 33:136–141. https://doi.org/10.1097/WCO.0000000000000771

Article  PubMed  Google Scholar 

Bigelow RT, Semenov YR, du Lac S et al (2016) Vestibular vertigo and comorbid cognitive and psychiatric impairment: the 2008 National Health Interview Survey. J Neurol Neurosurg Psychiatry 87:367–372. https://doi.org/10.1136/jnnp-2015-310319

Article  PubMed  Google Scholar 

Gurvich C, Maller JJ, Lithgow B et al (2013) Vestibular insights into cognition and psychiatry. Brain Res 1537:244–259. https://doi.org/10.1016/j.brainres.2013.08.058

Article  PubMed  Google Scholar 

Hamelsky SW, Lipton RB (2006) Psychiatric comorbidity of migraine. Headache J Head Face Pain 46:1327–1333. https://doi.org/10.1111/j.1526-4610.2006.00576.x

Article  Google Scholar 

Jackson MJ, Turkington D (2005) Depression and anxiety in epilepsy. J Neurol Neurosurg Psychiatry 76(Suppl 1):i45-47. https://doi.org/10.1136/jnnp.2004.060467

Article  PubMed  PubMed Central  Google Scholar 

Freeman D, Sheaves B, Waite F et al (2020) Sleep disturbance and psychiatric disorders. Lancet Psychiatry 7:628–637. https://doi.org/10.1016/S2215-0366(20)30136-X

Article  PubMed  Google Scholar 

Van Hecke R, Deconinck FJA, Van Acker E et al (2025) Vestibular function in children with neurodevelopmental disorders: a neglected sense? Clin Neurophysiol Off J Int Fed Clin Neurophysiol 171:1–10. https://doi.org/10.1016/j.clinph.2024.12.026

Article  Google Scholar 

Shalev D, Koolen DA, de Vries BBA et al (2024) Ocular manifestations in Koolen–de Vries syndrome: an international study. Can J Ophthalmol 59:e796–e802. https://doi.org/10.1016/j.jcjo.2023.11.021

Article  PubMed  Google Scholar 

Hanly C, Shah H, Au PYB, Murias K (2021) Description of neurodevelopmental phenotypes associated with 10 genetic neurodevelopmental disorders: a scoping review. Clin Genet 99:335–346. https://doi.org/10.1111/cge.13882

Article  PubMed  Google Scholar 

Choi K-D, Kim J-Y, Choi S-Y et al (2021) Case report: Ménière’s disease-like symptoms in 22q11.2 deletion syndrome. Front Neurol 12:690078. https://doi.org/10.3389/fneur.2021.690078

Article  PubMed  PubMed Central  Google Scholar 

Rhamati L, Marcolla A, Guerrot AM et al (2023) Audiological phenotyping evaluation in KBG syndrome: description of a multicenter review. Int J Pediatr Otorhinolaryngol 171:111606. https://doi.org/10.1016/j.ijporl.2023.111606

Article 

Comments (0)

No login
gif