Early combined conbercept and dexamethasone implant therapy for diabetic macular edema

Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K, Shaw JE, Bright D, Williams R (2019) Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas. Diabetes Res Clin Pract 157:107843

Article  PubMed  Google Scholar 

Tomić M, Vrabec R, Poljičanin T, Ljubić S, Duvnjak L (2017) Diabetic macular edema: traditional and novel treatment. Acta Clin Croat 56:124

Article  PubMed  Google Scholar 

He Y, Ren XJ, Hu BJ, Lam WC, Li XR (2018) A meta-analysis of the effect of a dexamethasone intravitreal implant versus intravitreal anti-vascular endothelial growth factor treatment for diabetic macular edema. BMC Ophthalmol 18:121

Article  PubMed  PubMed Central  Google Scholar 

Virgili G, Curran K, Lucenteforte E, Peto T, Parravano M (2023) Anti-vascular endothelial growth factor for diabetic macular oedema: a network meta-analysis. Cochrane Database Syst Rev 2023(6):CD007419. https://doi.org/10.1002/14651858.CD007419.pub7

PubMed  PubMed Central  Google Scholar 

Bressler NM, Beaulieu WT, Glassman AR, Blinder KJ, Bressler SB, Jampol LM, Melia M, Wells JA 3rd (2018) Diabetic Retinopathy Clinical Research Network. Persistent macular thickening following intravitreous aflibercept, bevacizumab, or ranibizumab for central-involved diabetic macular edema with vision impairment: a secondary analysis of a randomized clinical trial. JAMA Ophthalmol 136:257

Article  PubMed  PubMed Central  Google Scholar 

Wong WM, Chee C, Bhargava M, Chai C, Lin H, Zhao P, Ariadarma Mangunkusumo E, Naing T, Yuen YS, Wong TY, Su X, Lingam G (2020) Systemic factors associated with treatment response in diabetic macular edema. J Ophthalmol 2020:1875860

Article  PubMed  PubMed Central  Google Scholar 

Miao JP, Zeng YY, Gu XM, Zhang XY (2024) Short-term fluctuation of intraocular pressure and influencing factors following intravitreal injection in patients with retinal vascular diseases. Int J Ophthalmol 17:2052

Article  PubMed  PubMed Central  Google Scholar 

Li LY, Li J, Li Y, Zhang W, Wang DY, Wang WL, Liang BY, Gu W (2023) Efficacy and safety of intravitreal dexamethasone implant in diabetic macular edema patients with and without prior vitrectomy: a retrospective cohort study. Zhonghua Yan Ke Za Zhi 59:398

CAS  PubMed  Google Scholar 

Maturi RK, Glassman AR, Liu D, Beck RW, Bhavsar AR, Bressler NM, Jampol LM, Melia M, Punjabi OS, Salehi-Had H, Sun JK (2018) Effect of adding dexamethasone to continued ranibizumab treatment in patients with persistent diabetic macular edema: a DRCR network phase 2 randomized clinical trial. JAMA Ophthalmol 136:29

Article  PubMed  Google Scholar 

Semeraro F, Morescalchi F, Cancarini A, Russo A, Rezzola S, Costagliola C (2019) Diabetic retinopathy, a vascular and inflammatory disease: Therapeutic implications. Diabetes Metab 45(6):517–527. https://doi.org/10.1016/j.diabet.2019.04.002

Urias EA, Urias GA, Monickaraj F, McGuire P, Das A (2017) Vision Res 139:221

Article  PubMed  Google Scholar 

Semeraro F, Morescalchi F, Cancarini A, Russo A, Rezzola S, Costagliola C (2019) Diabetic retinopathy, a vascular and inflammatory disease: therapeutic implications. Diabetes Metab 45:517

Article  CAS  PubMed  Google Scholar 

Khan Z, Kuriakose RK, Khan M, Chin EK, Almeida DR (2017) Efficacy of the intravitreal sustained-release dexamethasone implant for diabetic macular edema refractory to anti-vascular endothelial growth factor therapy: meta-analysis and clinical implications. Ophthalmic Surg Lasers Imaging Retina 48:160

Article  PubMed  Google Scholar 

Wolfe JD, Shah AR, Yonekawa Y, Al Faran A, Franklin MS, Abbey AM, Capone A Jr (2023) Differences between young and elderly polypoidal choroidal vasculopathy patients with and without pachychoroid phenotypes. Eur J Ophthalmol 26:168

Article  Google Scholar 

Taloni A, Coco G, Rastelli D, Buffon G, Scorcia V, Giannaccare G (2023) Safety and efficacy of dexamethasone intravitreal implant given either first-line or second-line in diabetic macular edema. Patient Prefer Adherence 17:3307

Article  PubMed  PubMed Central  Google Scholar 

Wu P, Zhang P, Xu J, Ma W, Li L, Xu H (2024) Intravitreal Injection of Conbercept Combined with Dexamethasone for Macular Edema Following Central Retinal Vein Occlusion. Clin Ophthalmol 18:1851

Article  PubMed  PubMed Central  Google Scholar 

Busch C, Fraser-Bell S, Iglicki M, Lupidi M, Couturier A, Chaikitmongkol V, Giancipoli E, Rodríguez-Valdés PJ, Gabrielle PH, Laíns I, Santos AR, Cebeci Z, Amphornphruet A, Degenhardt V, Unterlauft JD, Cagini C, Mané-Tauty V, D’Amico Ricci G, Hindi I, Agrawal K, Chhablani J, Loewenstein A, Zur D, Rehak M (2019) Real-world outcomes of non-responding diabetic macular edema treated with continued anti-VEGF therapy versus early switch to dexamethasone implant: 2-year results. Acta Diabetol 2019(56):1341

Article  Google Scholar 

Zur D, Iglicki M, Busch C, Invernizzi A, Mariussi M, Loewenstein A (2018) OCT biomarkers as functional outcome predictors in diabetic macular edema treated with dexamethasone implant. Ophthalmology 125:267

Article  PubMed  Google Scholar 

Boyer DS, Yoon YH, Belfort R Jr, Bandello F, Maturi RK, Augustin AJ, Li XY, Cui H, Hashad Y, Whitcup SM (2014) Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema. Ophthalmology 121:1904

Article  PubMed  Google Scholar 

Klamann A, Böttcher K, Ackermann P, Geerling G, Schargus M, Guthoff R (2016) Intravitreal dexamethasone implant for the treatment of postoperative macular edema. Ophthalmologica 236:181

Article  CAS  PubMed  Google Scholar 

Callanan DG, Loewenstein A, Patel SS, Massin P, Corcóstegui B, Li XY, Jiao J, Hashad Y, Whitcup SM (2017) A multicenter, 12-month randomized study comparing dexamethasone intravitreal implant with ranibizumab in patients with diabetic macular edema. Graefes Arch Clin Exp Ophthalmol 255:463

Article  CAS  PubMed  Google Scholar 

Mehta H, Fraser-Bell S, Nguyen V, Lim LL, Gillies MC (2018) The interval between treatments of bevacizumab and dexamethasone implants for diabetic macular edema increased over time in the BEVORDEX trial. Ophthalmol Retina 2:231

Article  PubMed  Google Scholar 

Comments (0)

No login
gif