Cancer [Internet]. [cited 2025 Feb 28]. Available from: https://www.who.int/news-room/fact-sheets/detail/cancer
Prasanth BK, Alkhowaiter S, Sawarkar G, Dharshini BD, Baskaran RA. Unlocking Early Cancer Detection: Exploring Biomarkers, Circulating DNA, and Innovative Technological Approaches. Cureus. 2023;15:e51090.
PubMed PubMed Central Google Scholar
Janku F. Tumor heterogeneity in the clinic: is it a real problem? Ther Adv Med Oncol. 2014;43:1.
Ibrahim J, Peeters M, Van Camp G, Op de Beeck K. Methylation biomarkers for early cancer detection and diagnosis: Current and future perspectives. Eur J Cancer. 2023;178:91–113.
Taryma-Leśniak O, Sokolowska KE, Wojdacz TK. Current status of development of methylation biomarkers for in vitro diagnostic IVD applications. Clin Epigenetics. 2020;12:1–16. https://doi.org/10.1186/s13148-020-00886-6.
Yu X, Zhao H, Wang R, Chen Y, Ouyang X, Li W, et al. Cancer epigenetics: from laboratory studies and clinical trials to precision medicine. Cell Death Dis. 2024;10:1–12.
Esteller M. Epigenetic gene silencing in cancer: the DNA hypermethylome. Hum Mol Genet. 2007;16:R50-9. https://doi.org/10.1093/hmg/ddm018.
Li L, Sun Y. Circulating tumor DNA methylation detection as biomarker and its application in tumor liquid biopsy: advances and challenges. MedComm. 2024;5:1.
Lo YMD, Han DSC, Jiang P, Chiu RWK. Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies. Science. 2021;372:1.
Lakshminarasimhan R, Liang G. The Role of DNA Methylation in Cancer. Adv Exp Med Biol. 2016;945:151.
Article PubMed PubMed Central Google Scholar
Tran KA, Kondrashova O, Bradley A, Williams ED, Pearson JV, Waddell N. Deep learning in cancer diagnosis, prognosis and treatment selection. Genome Med. 2021;13:152.
Article PubMed PubMed Central Google Scholar
Thedinga K, Herwig R. A gradient tree boosting and network propagation derived pan-cancer survival network of the tumor microenvironment. iScience. 2022;25:103617.
Kisiel JB, Ebbert JO, Taylor WR, Marinac CR, Choudhry OA, Rego SP, et al. Shifting the Cancer Screening Paradigm: Developing a Multi-Biomarker Class Approach to Multi-Cancer Early Detection Testing Life. Basel: Multidisciplinary Digital Publishing Institute (MDPI); 2024.
Miller SJ, Sly JR, Rolfo C, Mack P, Villanueva A, Mazor M, et al. Multi-cancer early detection (MCED) tests: prioritizing equity from bench to bedside. Health Affairs Scholar. 2024. https://doi.org/10.1093/haschl/qxae039.
Article PubMed PubMed Central Google Scholar
Hassija V, Chamola V, Mahapatra A, Singal A, Goel D, Huang K, et al. Interpreting Black-Box Models: A Review on Explainable Artificial Intelligence. Cognit Comput. 2024;16:45–74. https://doi.org/10.1007/s12559-023-10179-8.
Sharma S, Kelly TK, Jones PA. Epigenetics in cancer. Carcinogenesis. 2009;1:27–36.
Oldenhuis CNAM, Oosting SF, Gietema JA, de Vries EGE. Prognostic versus predictive value of biomarkers in oncology. Eur J Cancer. 2008;44:946–53.
Rezkitha YAA, Panenggak NSR, Lusida MI, Rianda RV, Mahmudah I, Pradana AD, et al. Detecting colorectal cancer using genetic and epigenetic biomarkers: screening and diagnosis. J Med Life. 2024;2024:4–14.
Anghel SA, Ioniță-Mîndrican CB, Luca I, Pop AL. Promising Epigenetic Biomarkers for the Early Detection of Colorectal Cancer: A Systematic Review. Cancers (Basel). 2021;1:13.
Wu D, Zhou G, Jin P, Zhu J, Li S, Wu Q, et al. Detection of Colorectal Cancer Using a Simplified SEPT9 Gene Methylation Assay Is a Reliable Method for Opportunistic Screening. J Mol Diagnost. 2016;18:535–45.
Palanca-Ballester C, Rodriguez-Casanova A, Torres S, Calabuig-Fariñas S, Exposito F, Serrano D, et al. Cancer epigenetic biomarkers in liquid biopsy for high incidence malignancies. Cancers (Basel). 2021;13:3016.
Abolghasemi Fard A, Mahmoodzadeh A. Unraveling the Progression of Colon Cancer Pathogenesis Through Epigenetic Alterations and Genetic Pathways. Cureus. 2024;1:1.
Sheaffer KL, Elliott EN, Kaestner KH. DNA hypomethylation contributes to genomic instability and intestinal cancer initiation. Cancer Prevent Res. 2016;9:534–46.
Zhang C, Sheng Q, Zhao N, Huang S, Zhao Y. DNA hypomethylation mediates immune response in pan-cancer. Epigenetics. 2023;18:1.
Liu C, Tang H, Hu N, Li T. Methylomics and cancer: the current state of methylation profiling and marker development for clinical care. Cancer Cell Int. 2023;1:1.
Gu X, Huang X, Zhang X, Wang C. Development and Validation of a DNA Methylation-related Classifier of Circulating Tumour Cells to Predict Prognosis and to provide a therapeutic strategy in Lung Adenocarcinoma. Int J Biol Sci. 2022;18:4984–5000.
Article PubMed PubMed Central Google Scholar
Lee W, Kim S, An J, Kim T-K, Cha H, Chang H, et al. Tristetraprolin regulates phagocytosis through interaction with CD47 in head and neck cancer. Exp Ther Med. 2022;24:1.
Nass SJ, Herman JG, Gabrielson E, Iversen PW, Parl FF, Davidson NE, et al. Human Breast Cancer CpG Islands Increases with Malignant Progression in ′ 5 Aberrant Methylation of the Estrogen Receptor and E-Cadherin E-mail alerts Aberrant Methylation of the Estrogen Receptor and E-Cadherin 5 CpG Islands Increases with Malignant Progression in Human Breast Cancer 1 [Internet]. Cancer Res Downloaded from. 2000. Available from: http://cancerres.aacrjournals.org/content/60/16/4346
Detection of Aberrant Promoter Hypermethylation of Tumor Suppressor Genes in Serum DNA from Non-Small Cell Lung Cancer Patients1 | Cancer Research | American Association for Cancer Research [Internet]. [cited 2025 Mar 24]. Available from: https://aacrjournals.org/cancerres/article/59/1/67/505065/Detection-of-Aberrant-Promoter-Hypermethylation-of
Luo J, Chen S, Chen J, Zhou Y, He F, Wang E. Identification and validation of DNA methylation markers to predict axillary lymph node metastasis of breast cancer. PLoS One. 2022;17:1.
Wen DS, Huang LC, Bu XY, He MK, Lai ZC, Du ZF, et al. DNA methylation-activated full-length EMX1 facilitates metastasis through EMX1-EGFR-ERK axis in hepatocellular carcinoma. Cell Death Dis. 2023;14:1.
Zhu D, Zeng S, Su C, Li J, Xuan Y, Lin Y, et al. The interaction between DNA methylation and tumor immune microenvironment: from the laboratory to clinical applications. Clin Epigenetics. 2024;16:1.
Zhu D, Zeng S, Su C, Li J, Xuan Y, Lin Y, et al. The interaction between DNA methylation and tumor immune microenvironment: from the laboratory to clinical applications. Clin Epigenet. 2024;2024:1.
Zhang C, Guo L, Su Z, Luo N, Tan Y, Xu P, et al. Tumor Immune Microenvironment Landscape in Glioma Identifies a Prognostic and Immunotherapeutic Signature. Front Cell Dev Biol. 2021;9:1.
Yu R, Huang X, Lin J, Lin S, Shen G, Chen W. Bioinformatics analysis based on DNA methylation data identified in lung adenocarcinoma subgroups with different immune characteristics and clinical outcomes. J Thorac Dis. 2023;15:2184–97.
Article PubMed PubMed Central Google Scholar
Antonios P-S, Aldape K. Annual Review of Pathology: Mechanisms of Disease DNA Methylation Profiling: An Emerging Paradigm for Cancer Diagnosis. Downloaded from www.annualreviews.org Guest (guest [Internet]. 2024;09:19. Available from: https://doi.org/10.1146/annurev-pathol-042220-
Yong WS, Hsu FM, Chen PY. Profiling genome-wide DNA methylation. Epigenet Chrom. 2016;9:1–16. https://doi.org/10.1186/s13072-016-0075-3.
Laird PW. Principles and challenges of genome-wide DNA methylation analysis. Nat Rev Genet. 2010;11:191–203.
Rauluseviciute I, Drabløs F, Rye MB. DNA methylation data by sequencing: Experimental approaches and recommendations for tools and pipelines for data analysis. Clin Epigeneti. 2019;2019:1.
Liu Q, Fang L, Yu G, Wang D, Le Xiao C, Wang K. Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data. Nat Commun. 2019;10:1.
Sahoo K, Sundararajan V. Methods in DNA methylation array dataset analysis: A review. Comput Struct Biotechnol J. 2024;1:2304–25.
Gao Y, Zhao H, An K, Liu Z, Hai L, Li R, et al. Whole-genome bisulfite sequencing analysis of circulating tumour DNA for the detection and molecular classification of cancer. Clin Transl Med. 2022;1:12.
Carrizosa-Molina T, Casillas-Díaz N, Pérez-Nadador I, Vales-Villamarín C, López-Martínez MÁ, Riveiro-Álvarez R, et al. Methylation analysis by targeted bisulfite sequencing in large for gestational age (LGA) newborns: the LARGAN cohort. Clin Epigenet. 2023;15:1.
Gu H, Smith ZD, Bock C, Boyle P, Gnirke A, Meissner A. Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling. Nat Protoc. 2011;6:468–81.
Staunstrup NH, Starnawska A, Nyegaard M, Christiansen L, Nielsen AL, Børglum A, et al. Genome-wide DNA methylation profiling with MeDIP-seq using archived dried blood spots. Clin Epigenet. 2016;8:1.
Vandenhoeck J, Neefs I, Vanpoucke T, Ibrahim J, Suls A, Peet
Comments (0)