CXCR4-directed PET with Ga-pentixafor versus adrenal vein sampling for the diagnosis of unilateral primary aldosteronism

A.F. Turcu, J. Yang, A. Vaidya, Primary aldosteronism - a multidimensional syndrome. Nat Rev. Endocrinol. 18(11), 665–682 (2022). https://doi.org/10.1038/s41574-022-00730-2.

Article  PubMed  Google Scholar 

T.A. Williams, J. Lenders, P. Mulatero, J. Burrello, M. Rottenkolber, C. Adolf, F. Satoh, L. Amar, M. Quinkler, J. Deinum, F. Beuschlein, K.K. Kitamoto, U. Pham, R. Morimoto, H. Umakoshi, A. Prejbisz, T. Kocjan, M. Naruse, M. Stowasser, T. Nishikawa, W.F. Young Jr, C.E. Gomez-Sanchez, J.W. Funder, M. Reincke, Primary Aldosteronism Surgery Outcome (PASO), Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort. Lancet Diabetes Endocrinol. 5(9), 689–699 (2017). https://doi.org/10.1016/S2213-8587(17)30135-3.

Article  PubMed  PubMed Central  Google Scholar 

S. Samnani, I. Cenzer, G.A. Kline, S.J. Lee, G.L. Hundemer, C. McClurg, J.L. Pasieka, W.J. Boscardin, P.E. Ronksley, A.A. Leung, Time to benefit of surgery vs targeted medical therapy for patients with primary aldosteronism: a meta-analysis. J Clin. Endocrinol. Metab. 109(3), e1280–e1289 (2024). https://doi.org/10.1210/clinem/dgad654.

Article  PubMed  Google Scholar 

P. Mulatero, S. Monticone, J. Deinum, L. Amar, A. Prejbisz, M.C. Zennaro, F. Beuschlein, G.P. Rossi, T. Nishikawa, A. Morganti, T.M. Seccia, Y.H. Lin, F. Fallo, J. Widimsky, Genetics, prevalence, screening and confirmation of primary aldosteronism: a position statement and consensus of the Working Group on Endocrine Hypertension of The European Society of Hypertension. J Hypertens. 38(10), 1919–1928 (2020). https://doi.org/10.1097/HJH.0000000000002510.

Article  CAS  PubMed  Google Scholar 

J.W. Funder, R.M. Carey, F. Mantero, M.H. Murad, M. Reincke, H. Shibata, M. Stowasser, W.F. Young Jr, The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice guideline. J Clin. Endocrinol. Metab. 101(5), 1889–1916 (2016). https://doi.org/10.1210/jc.2015-4061.

Article  CAS  PubMed  Google Scholar 

M. Naruse, T. Katabami, H. Shibata, M. Sone, K. Takahashi, A. Tanabe, S. Izawa, T. Ichijo, M. Otsuki, M. Omura, Y. Ogawa, Y. Oki, I. Kurihara, H. Kobayashi, R. Sakamoto, F. Satoh, Y. Takeda, T. Tanaka, K. Tamura, M. Tsuiki, S. Hashimoto, T. Hasegawa, T. Yoshimoto, T. Yoneda, K. Yamamoto, H. Rakugi, N. Wada, A. Saiki, Y. Ohno, T. Haze, Japan endocrine society clinical practice guideline for the diagnosis and management of primary aldosteronism 2021. Endocr J. 69(4), 327–359 (2022). https://doi.org/10.1507/endocrj.EJ21-0508.

Article  PubMed  Google Scholar 

B. Heinze, C.T. Fuss, P. Mulatero, F. Beuschlein, M. Reincke, M. Mustafa, A. Schirbel, T. Deutschbein, T.A. Williams, Y. Rhayem, M. Quinkler, N. Rayes, S. Monticone, V. Wild, C.E. Gomez-Sanchez, A.C. Reis, S. Petersenn, H.J. Wester, S. Kropf, M. Fassnacht, K. Lang, K. Herrmann, A.K. Buck, C. Bluemel, S. Hahner, Targeting CXCR4 (CXC chemokine receptor Type 4) for molecular imaging of aldosterone-producing adenoma. Hypertension 71(2), 317–325 (2018). https://doi.org/10.1161/HYPERTENSIONAHA.117.09975.

Article  CAS  PubMed  Google Scholar 

Y. Gao, J. Ding, Y. Cui, T. Li, H. Sun, D. Zhao, Y. Zhang, L. Huo, A. Tong, Functional nodules in primary aldosteronism: identification of CXCR4 expression with (68)Ga-pentixafor PET/CT. Eur Radio. 33(2), 996–1003 (2023). https://doi.org/10.1007/s00330-022-09058-x.

Article  CAS  Google Scholar 

J. Hu, T. Xu, H. Shen, Y. Song, J. Yang, A. Zhang, H. Ding, N. Xing, Z. Li, L. Qiu, L. Ma, Y. Yang, Z. Feng, Z. Du, W. He, Y. Sun, J. Cai, Q. Li, Y. Chen, S. Yang, Chongqing Primary Aldosteronism Study (CONPASS) G., Accuracy of gallium-68 pentixafor positron emission tomography-computed tomography for subtyping diagnosis of primary aldosteronism. JAMA Netw. Open 6(2), e2255609 (2023). https://doi.org/10.1001/jamanetworkopen.2022.55609.

Article  PubMed  PubMed Central  Google Scholar 

T. Jia, C. Tao, T. Lu, X. Jing, X. Chen-Xiao, H. Lu, T. Hao-Ming, R. Yan, Suitable cutoff value of aldosterone to renin concentration ratio measured by chemiluminescence for screening primary aldosteronism among hypertensive population in sichuan. Chin J. Hypertens. 31(3), 241–246 (2023).

Google Scholar 

B. Liu, J. Hu, Y. Song, W. He, Q. Cheng, Z. Wang, Z. Feng, Z. Du, Z. Xu, J. Yang, Q. Li, S. Yang, Chongqing Primary Aldosteronism Study (CONPASS) G., Seated saline suppression test is comparable with captopril challenge test for the diagnosis of primary aldosteronism: a prospective study. Endocr Pr. 27(4), 326–333 (2021). https://doi.org/10.1016/j.eprac.2020.10.016.

Article  Google Scholar 

N. Younes, S. Larose, I. Bourdeau, E. Therasse, A. Lacroix, Role of adrenal vein sampling in guiding surgical decision in primary aldosteronism. Exp Clin. Endocrinol. Diabetes 131(7-08), 418–434 (2023). https://doi.org/10.1055/a-2106-4663.

Article  PubMed  Google Scholar 

Z. Yushi, T. Anli, H. Li, Consensus on clinical application of the CXCR4-targeted imaging in the diagnosis of primary aldosteronism. Medical J. Peking. Union Med. Coll. Hospital 13(6), 986–991 (2022).

Google Scholar 

T.A. Williams, C.E. Gomez-Sanchez, W.E. Rainey, T.J. Giordano, A.K. Lam, A. Marker, O. Mete, Y. Yamazaki, M. Zerbini, F. Beuschlein, F. Satoh, J. Burrello, H. Schneider, J. Lenders, P. Mulatero, I. Castellano, T. Knösel, M. Papotti, W. Saeger, H. Sasano, M. Reincke, International histopathology consensus for unilateral primary aldosteronism. J Clin. Endocrinol. Metab. 106(1), 42–54 (2021). https://doi.org/10.1210/clinem/dgaa484.

Article  PubMed  Google Scholar 

A. Saadi, M.A. Bedoui, S. Mokadem, S. Zaghbib, H. Boussaffa, M. Bellali, H. Ayed, A. Bouzouita, A. Derouiche, M. Allouche, M. Chakroun, R.B. Slama, Anatomy and anatomical variations of adrenal veins and its application to adrenal venous sampling. Surg Radio. Anat. 46(4), 543–550 (2024). https://doi.org/10.1007/s00276-024-03331-y.

Article  Google Scholar 

M. Araujo-Castro, M. Paja Fano, M. González Boillos, B. Pla Peris, E. Pascual-Corrales, A.M. García Cano, P. Parra Ramírez, P.M. Rojas-Marcos, J.G. Ruiz-Sanchez, A. Vicente Delgado, E. Gómez Hoyos, R. Ferreira, I. García Sanz, M. Recasens Sala, R. Barahona San Millan, M.J. Picón César, P. Díaz Guardiola, J.J. García González, C.M. Perdomo, L. Manjón Miguélez, R. García Centeno, J.C. Percovich, Á Rebollo Román, P. Gracia Gimeno, C. Robles Lázaro, M. Morales-Ruiz, F.A. Hanzu, Adrenal venous sampling in primary aldosteronism: experience of a Spanish multicentric study (Results from the SPAIN-ALDO register). Endocrine 78(2), 363–372 (2022). https://doi.org/10.1007/s12020-022-03122-8.

Article  CAS  PubMed  Google Scholar 

S. Kumasaka, H. Tokue, Y. Tsushima, Difficulty factors of adrenal venous sampling based on patient characteristics and imaging findings. Acta Radio. 63(9), 1276–1282 (2022). https://doi.org/10.1177/02841851211034046.

Article  Google Scholar 

N. Furuta, T. Naruoka, T. Igarashi, S. Bando, H. Yamada, T. Kimura, S. Egawa, Clinical evaluation of primary aldosteronism with subclinical Cushing’s syndrome. Hinyokika Kiyo 61(5), 185–190 (2015).

PubMed  Google Scholar 

K. Fujimoto, S. Honjo, H. Tatsuoka, Y. Hamamoto, Y. Kawasaki, A. Matsuoka, H. Ikeda, Y. Wada, H. Sasano, H. Koshiyama, Primary aldosteronism associated with subclinical Cushing syndrome. J Endocrinol. Invest 36(8), 564–567 (2013). https://doi.org/10.3275/8818.

Article  CAS  PubMed  Google Scholar 

G. Ceolotto, G. Antonelli, B. Caroccia, M. Battistel, G. Barbiero, M. Plebani, G.P. Rossi, Comparison of cortisol, androstenedione and metanephrines to assess selectivity and lateralization of adrenal vein sampling in primary aldosteronism. J Clin. Med 10(20), 4755 (2021). https://doi.org/10.3390/jcm10204755.

Article  CAS  PubMed  PubMed Central  Google Scholar 

X. Wu, R. Senanayake, E. Goodchild, W.A. Bashari, J. Salsbury, C.P. Cabrera, G. Argentesi, S.M. O'Toole, M. Matson, B. Koo, L. Parvanta, N. Hilliard, V. Kosmoliaptsis, A. Marker, D.M. Berney, W. Tan, R. Foo, C.A. Mein, E. Wozniak, E. Savage, A. Sahdev, N. Bird, K. Laycock, I. Boros, S. Hader, V. Warnes, D. Gillett, A. Dawnay, E. Adeyeye, A. Prete, A.E. Taylor, W. Arlt, A.N. Bhuva, F. Aigbirhio, C. Manisty, A. McIntosh, A. McConnachie, J.K. Cruickshank, H. Cheow, M. Gurnell, W.M. Drake, M.J. Brown, [(11)C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial. Nat Med 29(1), 190–202 (2023). https://doi.org/10.1038/s41591-022-02114-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

T.H. Puar, C.M. Khoo, C.J. Tan, A. Tong, M. Tan, A.E. Teo, K.S. Ng, K.M. Wong, A. Reilhac, J. O'Doherty, C.E. Gomez-Sanchez, P.C. Kek, S. Yee, A. Tan, M.B. Chuah, D. Lee, K.W. Wang, C.Q. Zheng, L. Shi, E.G. Robins, R. Foo, for the PA CURE investigators, 11C-metomidate PET-CT versus adrenal vein sampling to subtype primary aldosteronism: a prospective clinical trial. J Hypertens. 40(6), 1179–1188 (2022). https://doi.org/10.1097/HJH.0000000000003132.

Article  CAS  PubMed  Google Scholar 

J. Burrello, A. Burrello, J. Pieroni, E. Sconfienza, V. Forestiero, P. Rabbia, C. Adolf, M. Reincke, F. Veglio, T.A. Williams, S. Monticone, P. Mulatero, Development and validation of prediction models for subtype diagnosis of patients with primary aldosteronism. J Clin. Endocrinol. Metab. 105(10), dgaa379 (2020). https://doi.org/10.1210/clinem/dgaa379.

Article  PubMed  Google Scholar 

Z. Chen, A. Yang, J. Zhang, A. Chen, Y. Zhang, C. Huang, S. Chen, S. Yao, W. Miao, CXCR4-directed PET/CT with [(68)Ga]Pentixafor in central nervous system lymphoma: a comparison with [(18)F]FDG PET/CT. Mol Imaging Biol. 24(3), 416–424 (2022). https://doi.org/10.1007/s11307-021-01664-3.

Article  CAS  PubMed  Google Scholar 

S. Kraus, A. Dierks, L. Rasche, O. Kertels, M. Kircher, A. Schirbel, J. Zovko, T. Steinbrunn, R. Tibes, H.J. Wester, A.K. Buck, H. Einsele, K.M. Kortüm, A. Rosenwald, C. Lapa, (68)Ga-pentixafor PET/CT for detection of chemokine receptor CXCR4 expression in myeloproliferative neoplasms. J Nucl. Med 63(1), 96–99 (2022). https://doi.org/10.2967/jnumed.121.262206.

Article  CAS  PubMed  PubMed Central  Google Scholar 

T. Derlin, D.G. Sedding, J. Dutzmann, A. Haghikia, T. König, L.C. Napp, C. Schütze, N. Owsianski-Hille, H.J. Wester, S. Kropf, J.T. Thackeray, J.P. Bankstahl, L. Geworski, T.L. Ross, J. Bauersachs, F.M. Bengel, Imaging of chemokine receptor CXCR4 expression in culprit and nonculprit coronary atherosclerotic plaque using motion-corrected [(68)Ga]pentixafor PET/CT. Eur J. Nucl. Med Mol. Imaging 45(11), 1934–1944 (2018). https://doi.org/10.1007/s00259-018-4076-2.

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