Extracellular Vesicles and Immune Activation in Solid Organ Transplantation: The Impact of Immunosuppression

Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7:1535750. https://doi.org/10.1080/20013078.2018.1535750.

Article  PubMed  PubMed Central  Google Scholar 

Caby M-P, Lankar D, Vincendeau-Scherrer C, Raposo G, Bonnerot C. Exosomal-like vesicles are present in human blood plasma. Int Immunol. 2005;17:879–87. https://doi.org/10.1093/intimm/dxh267.

Article  CAS  PubMed  Google Scholar 

Pisitkun T, Shen R-F, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci USA. 2004;101:13368–73. https://doi.org/10.1073/pnas.0403453101.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colombo M, Raposo G, Théry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30:255–89. https://doi.org/10.1146/annurev-cellbio-101512-122326.

Article  CAS  PubMed  Google Scholar 

Liu A, Hefley B, Escandon P, Nicholas SE, Karamichos D. Salivary exosomes in health and disease: future prospects in the eye. Int J Mol Sci. 2023;24:6363. https://doi.org/10.3390/ijms24076363.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vallabhajosyula P, Korutla L, Habertheuer A, Reddy S, Schaufler C, Lasky J, et al. Ex vivo lung perfusion model to study pulmonary tissue extracellular microvesicle profiles. Ann Thorac Surg. 2017;103:1758–66. https://doi.org/10.1016/j.athoracsur.2016.11.074.

Article  PubMed  PubMed Central  Google Scholar 

Eapen MS, Hansbro PM, Larsson-Callerfelt A-K, Jolly MK, Myers S, Sharma P, et al. Chronic obstructive pulmonary disease and lung cancer: underlying pathophysiology and new therapeutic modalities. Drugs. 2018;78:1717–40. https://doi.org/10.1007/s40265-018-1001-8.

Article  PubMed  Google Scholar 

Woud WW, Merino A, Hoogduijn MJ, Boer K, van den Hoogen MWF, Baan CC, et al. Nanoparticle release by extended criteria donor kidneys during normothermic machine perfusion. Transplantation. 2019;103: e110. https://doi.org/10.1097/TP.0000000000002642.

Article  PubMed  Google Scholar 

Woud WW, Arykbaeva AS, Alwayn IPJ, Baan CC, Minnee RC, Hoogduijn MJ, et al. Extracellular vesicles released during normothermic machine perfusion are associated with human donor kidney characteristics. Transplantation. 2022;106:2360–9. https://doi.org/10.1097/TP.0000000000004215.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma L, Li Y, Peng J, Wu D, Zhao X, Cui Y, et al. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015;25:24–38. https://doi.org/10.1038/cr.2014.135.

Article  CAS  PubMed  Google Scholar 

Rawal SU, Patel BM, Patel MM. New drug delivery systems developed for brain targeting. Drugs. 2022;82:749–92. https://doi.org/10.1007/s40265-022-01717-z.

Article  CAS  PubMed  Google Scholar 

Buzas EI. The roles of extracellular vesicles in the immune system. Nat Rev Immunol. 2023;23:236–50. https://doi.org/10.1038/s41577-022-00763-8.

Article  CAS  PubMed  Google Scholar 

Bansal S, Rahman M, Ravichandran R, Canez J, Fleming T, Mohanakumar T. Extracellular vesicles in transplantation: friend or foe. Transplantation. 2024;108:374. https://doi.org/10.1097/TP.0000000000004693.

Article  PubMed  Google Scholar 

Del Vecchio L, Allinovi M, Comolli S, Peiti S, Rimoldi C, Locatelli F. Drugs in development to treat IgA nephropathy. Drugs. 2024;84:503–25. https://doi.org/10.1007/s40265-024-02036-1.

Article  CAS  PubMed  Google Scholar 

Duneton C, Winterberg PD, Ford ML. Activation and regulation of alloreactive T cell immunity in solid organ transplantation. Nat Rev Nephrol. 2022;18:663–76. https://doi.org/10.1038/s41581-022-00600-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marino J, Babiker-Mohamed MH, Crosby-Bertorini P, Paster JT, LeGuern C, Germana S, et al. Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation. Sci Immunol. 2016;1:aaf8759. https://doi.org/10.1126/sciimmunol.aaf8759.

Article  PubMed  PubMed Central  Google Scholar 

Liu Q, Rojas-Canales DM, Divito SJ, Shufesky WJ, Stolz DB, Erdos G, et al. Donor dendritic cell–derived exosomes promote allograft-targeting immune response. J Clin Invest. 2016;126:2805–20. https://doi.org/10.1172/JCI84577.

Article  PubMed  PubMed Central  Google Scholar 

Wahlgren J, Karlson TDL, Glader P, Telemo E, Valadi H. Activated human T cells secrete exosomes that participate in IL-2 mediated immune response signaling. PLoS ONE. 2012;7: e49723. https://doi.org/10.1371/journal.pone.0049723.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui B, Chen X-J, Sun J, Li S-P, Zhou G-P, Sun L-Y, et al. Dendritic cells originating exosomal miR-193b-3p induces regulatory T cells to alleviate liver transplant rejection. Int Immunopharmacol. 2023;114: 109541. https://doi.org/10.1016/j.intimp.2022.109541.

Article  CAS  PubMed  Google Scholar 

Sigdel TK, Ng YW, Lee S, Nicora CD, Qian W-J, Smith RD, et al. Perturbations in the urinary exosome in transplant rejection. Front Med (Lausanne). 2015;1:57. https://doi.org/10.3389/fmed.2014.00057.

Article  PubMed  Google Scholar 

Lim J-H, Lee C-H, Kim KY, Jung H-Y, Choi J-Y, Cho J-H, et al. Novel urinary exosomal biomarkers of acute T cell-mediated rejection in kidney transplant recipients: a cross-sectional study. PLoS ONE. 2018;13: e0204204. https://doi.org/10.1371/journal.pone.0204204.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tower CM, Reyes M, Nelson K, Leca N, Kieran N, Muczynski K, et al. Plasma C4d+ endothelial microvesicles increase in acute antibody-mediated rejection. Transplantation. 2017;101:2235–43. https://doi.org/10.1097/TP.0000000000001572.

Article  CAS  PubMed  Google Scholar 

Zhang H, Huang E, Kahwaji J, Nast CC, Li P, Mirocha J, et al. Plasma exosomes from HLA-sensitized kidney transplant recipients contain mRNA transcripts which predict development of antibody-mediated rejection. Transplantation. 2017;101:2419–28. https://doi.org/10.1097/TP.0000000000001834.

Article  CAS  PubMed  Google Scholar 

Woud WW, Hesselink DA, Hoogduijn MJ, Baan CC, Boer K. Direct detection of circulating donor-derived extracellular vesicles in kidney transplant recipients. Sci Rep. 2022;12:21973. https://doi.org/10.1038/s41598-022-26580-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gunasekaran M, Xu Z, Nayak D, Sharma M, Hachem R, Walia R, et al. Donor-derived exosomes with lung self-antigens in human lung allograft rejection. Am J Transplant. 2017;17:474–84. https://doi.org/10.1111/ajt.13915.

Article  CAS  PubMed  Google Scholar 

Wojciechowski D, Wiseman A. Long-term immunosuppression management. Clin J Am Soc Nephrol. 2021;16:1264–71. https://doi.org/10.2215/CJN.15040920.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Niel G, D’Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19:213–28. https://doi.org/10.1038/nrm.2017.125.

Article  CAS  PubMed 

Comments (0)

No login
gif