Targeting the Neonatal Fc Receptor in Autoimmune Diseases: Pipeline and Progress

Wang L, Wang FS, Gershwin ME. Human autoimmune diseases: a comprehensive update. J Intern Med. 2015;278(4):369–95.

Article  CAS  PubMed  Google Scholar 

Wen X, Li B. A population-based study on autoimmune disease. Lancet. 2023;401(10391):1829–31.

Article  PubMed  Google Scholar 

Conrad N, Misra S, Verbakel JY, Verbeke G, Molenberghs G, Taylor PN, et al. Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK. Lancet. 2023;401(10391):1878–90.

Article  PubMed  Google Scholar 

Ludwig RJ, Vanhoorelbeke K, Leypoldt F, Kaya Z, Bieber K, McLachlan SM, et al. Mechanisms of autoantibody-induced pathology. Front Immunol. 2017;8:603.

Article  PubMed  PubMed Central  Google Scholar 

Eaton WW, Rose NR, Kalaydjian A, Pedersen MG, Mortensen PB. Epidemiology of autoimmune diseases in Denmark. J Autoimmun. 2007;29(1):1–9.

Article  PubMed  PubMed Central  Google Scholar 

Almutairi K, Nossent J, Preen D, Keen H, Inderjeeth C. The global prevalence of rheumatoid arthritis: a meta-analysis based on a systematic review. Rheumatol Int. 2021;41(5):863–77.

Article  PubMed  Google Scholar 

Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet. 2010;376(9746):1094–108.

Article  PubMed  Google Scholar 

McAlinden C. An overview of thyroid eye disease. Eye Vis. 2014;1:9.

Article  Google Scholar 

Volkov M, Coppola M, Huizinga R, Eftimov F, Huizinga TWJ, van der Kooi AJ, et al. Comprehensive overview of autoantibody isotype and subclass distribution. J Allergy Clin Immunol. 2022;150(5):999–1010.

Article  CAS  PubMed  Google Scholar 

Wu Y, Chen W, Chen H, Zhang L, Chang Y, Yan S, et al. The elevated secreted immunoglobulin D enhanced the activation of peripheral blood mononuclear cells in rheumatoid arthritis. PLoS ONE. 2016;11(1): e0147788.

Article  PubMed  PubMed Central  Google Scholar 

Zegers BJ, Stoop JW, Reerink-Brongers EE, Sander PC, Aalberse RC, Ballieux RE. Serum immunoglobulins in healthy children and adults: levels of the five classes, expressed in international units per millilitre. Clin Chim Acta. 1975;65(3):319–29.

Article  CAS  PubMed  Google Scholar 

Blaese RM, Strober W, Levy AL, Waldmann TA. Hypercatabolism of IgG, IgA, IgM, and albumin in the Wiskott-Aldrich syndrome: anique disorder of serum protein metabolism. J Clin Invest. 1971;50(11):2331–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Delacroix DL, Elkom KB, Geubel AP, Hodgson HF, Dive C, Vaerman JP. Changes in size, subclass, and metabolic properties of serum immunoglobulin A in liver diseases and in other diseases with high serum immunoglobulin A. J Clin Invest. 1983;71(2):358–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pisetsky DS. Pathogenesis of autoimmune disease. Nat Rev Nephrol. 2023;19(8):509–24.

Article  CAS  PubMed  Google Scholar 

Brambell FW, Hemmings WA, Oakley CL, Porter RR. The relative transmission of the fractions of papain hydrolyzed homologous gamma-globulin from the uterine cavity to the foetal circulation in the rabbit. Proc R Soc Lond B Biol Sci. 1960;151:478–82.

Article  CAS  PubMed  Google Scholar 

Brambell FW, Halliday R. The route by which passive immunity is transmitted from mother to foetus in the rat. Proc R Soc Lond B Biol Sci. 1956;145(919):170–8.

Article  CAS  PubMed  Google Scholar 

Brambell FW. The transmission of immunity from mother to young and the catabolism of immunoglobulins. Lancet. 1966;2(7473):1087–93.

Article  CAS  PubMed  Google Scholar 

Brambell FW, Hemmings WA, Morris IG. A theoretical model of gamma-globulin catabolism. Nature. 1964;203:1352–4.

Article  CAS  PubMed  Google Scholar 

Simister NE, Mostov KE. An Fc receptor structurally related to MHC class I antigens. Nature. 1989;337(6203):184–7.

Article  CAS  PubMed  Google Scholar 

Pyzik M, Sand KMK, Hubbard JJ, Andersen JT, Sandlie I, Blumberg RS. The neonatal Fc receptor (FcRn): a misnomer? Front Immunol. 2019;10:1540.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blumberg RS, Koss T, Story CM, Barisani D, Polischuk J, Lipin A, et al. A major histocompatibility complex class I-related Fc receptor for IgG on rat hepatocytes. J Clin Invest. 1995;95(5):2397–402.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pyzik M, Kozicky LK, Gandhi AK, Blumberg RS. The therapeutic age of the neonatal Fc receptor. Nat Rev Immunol. 2023;23(7):415–32.

Article  CAS  PubMed  Google Scholar 

West AP Jr, Bjorkman PJ. Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor. Biochemistry. 2000;39(32):9698–708.

Article  CAS  PubMed  Google Scholar 

Burmeister WP, Gastinel LN, Simister NE, Blum ML, Bjorkman PJ. Crystal structure at 2.2: a resolution of the MHC-related neonatal Fc receptor. Nature. 1994;372(6504):336–43.

Article  CAS  PubMed  Google Scholar 

Wani MA, Haynes LD, Kim J, Bronson CL, Chaudhury C, Mohanty S, et al. Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene. Proc Natl Acad Sci U S A. 2006;103(13):5084–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oganesyan V, Damschroder MM, Cook KE, Li Q, Gao C, Wu H, et al. Structural insights into neonatal Fc receptor-based recycling mechanisms. J Biol Chem. 2014;289(11):7812–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmidt MM, Townson SA, Andreucci AJ, King BM, Schirmer EB, Murillo AJ, et al. Crystal structure of an HSA/FcRn complex reveals recycling by competitive mimicry of HSA ligands at a pH-dependent hydrophobic interface. Structure. 2013;21(11):1966–78.

Article  CAS  PubMed  Google Scholar 

Rodewald R. pH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat. J Cell Biol. 1976;71(2):666–9.

Article  CAS  PubMed  Google Scholar 

Chaudhury C, Mehnaz S, Robinson JM, Hayton WL, Pearl DK, Roopenian DC, et al. The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med. 2003;197(3):315–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chaudhury C, Brooks CL, Carter DC, Robinson JM, Anderson CL. Albumin binding to FcRn: distinct from the FcRn-IgG interaction. Biochemistry. 2006;45(15):4983–90.

Article  CAS  PubMed  Google Scholar 

Andersen JT, Dee Qian J, Sandlie I. The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin. Eur J Immunol. 2006;36(11):3044–51.

Article  CAS  PubMed 

Comments (0)

No login
gif