Goetz SC, Anderson KV. The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet. 2010;11:331–44.
Article CAS PubMed PubMed Central Google Scholar
Tanos BE, Yang HJ, Soni R, Wang WJ, Macaluso FP, Asara JM, et al. Centriole distal appendages promote membrane docking, leading to cilia initiation. Genes Dev. 2013;27:163–8.
Article CAS PubMed PubMed Central Google Scholar
Ford MJ, Yeyati PL, Mali GR, Keighren MA, Waddell SH, Mjoseng HK, et al. A cell/cilia cycle biosensor for single-cell kinetics reveals persistence of cilia after G1/S transition is a general property in cells and mice. Dev Cell. 2018;47:509–23.e5.
Article CAS PubMed PubMed Central Google Scholar
Clement CA, Ajbro KD, Koefoed K, Vestergaard ML, Veland IR, Henriques de Jesus MP, et al. TGF-beta signaling is associated with endocytosis at the pocket region of the primary cilium. Cell Rep. 2013;3:1806–14.
Article CAS PubMed Google Scholar
Garcia-Gonzalo FR, Reiter JF. Open Sesame: how transition fibers and the transition zone control ciliary composition. Cold Spring Harb Perspect Biol. 2017;9:a028134.
Pedersen LB, Veland IR, Schroder JM, Christensen ST. Assembly of primary cilia. Dev Dyn. 2008;237:1993–2006.
Article CAS PubMed Google Scholar
Anvarian Z, Mykytyn K, Mukhopadhyay S, Pedersen LB, Christensen ST. Cellular signalling by primary cilia in development, organ function and disease. Nat Rev Nephrol. 2019;15:199–219.
Article PubMed PubMed Central Google Scholar
Bangs F, Anderson KV. Primary cilia and mammalian hedgehog signaling. Cold Spring Harb Perspect Biol. 2017;9:a028175.
Reiter JF, Leroux MR. Genes and molecular pathways underpinning ciliopathies. Nat Rev Mol Cell Biol. 2017;18:533–47.
Article CAS PubMed PubMed Central Google Scholar
Baker K, Beales PL. Making sense of cilia in disease: the human ciliopathies. Am J Med Genet C Semin Med Genet. 2009;151c:281–95.
Article CAS PubMed Google Scholar
Zeng H, Jia J, Liu A. Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium. PLoS ONE. 2010;5:e15900.
Article CAS PubMed PubMed Central Google Scholar
Niehrs C, Da Silva F, Seidl C. Cilia as Wnt signaling organelles. Trends in Cell Biology.2025;35:24–32.
Article CAS PubMed Google Scholar
Kim M, Kim M, Lee M-S, Kim C-H, Lim D-S. The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis. Nat Commun. 2014;5:5370.
Article CAS PubMed Google Scholar
Ezratty EJ, Stokes N, Chai S, Shah AS, Williams SE, Fuchs E. A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell. 2011;145:1129–41.
Article CAS PubMed PubMed Central Google Scholar
Schneider L, Clement CA, Teilmann SC, Pazour GJ, Hoffmann EK, Satir P, et al. PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts. Curr Biol. 2005;15:1861–6.
Article CAS PubMed Google Scholar
Milenkovic L, Weiss LE, Yoon J, Roth TL, Su YS, Sahl SJ, et al. Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1. Proc Natl Acad Sci USA. 2015;112:8320–5.
Article CAS PubMed PubMed Central Google Scholar
Yeh C, Li A, Chuang JZ, Saito M, Caceres A, Sung CH. IGF-1 activates a cilium-localized noncanonical Gbetagamma signaling pathway that regulates cell-cycle progression. Dev Cell. 2013;26:358–68.
Article CAS PubMed PubMed Central Google Scholar
Jenks AD, Vyse S, Wong JP, Kostaras E, Keller D, Burgoyne T, et al. Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer. Cell Rep. 2018;23:3042–55.
Article CAS PubMed PubMed Central Google Scholar
Han YG, Kim HJ, Dlugosz AA, Ellison DW, Gilbertson RJ, Alvarez-Buylla A. Dual and opposing roles of primary cilia in medulloblastoma development. Nat Med. 2009;15:1062–5.
Article CAS PubMed PubMed Central Google Scholar
Wong SY, Seol AD, So PL, Ermilov AN, Bichakjian CK, Epstein EH Jr., et al. Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis. Nat Med. 2009;15:1055–61.
Article CAS PubMed PubMed Central Google Scholar
Suizu F, Hirata N, Kimura K, Edamura T, Tanaka T, Ishigaki S, et al. Phosphorylation-dependent Akt-Inversin interaction at the basal body of primary cilia. EMBO J. 2016;35:1346–63.
Article CAS PubMed PubMed Central Google Scholar
Dilawari A, Buturla J, Osgood C, Gao X, Chen W, Ricks TK, et al. US Food and Drug Administration Approval Summary: Capivasertib With Fulvestrant for Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Locally Advanced or Metastatic Breast Cancer With PIK3CA/AKT1/PTEN Alterations. J Clin Oncol. 2024;42:4103–13.
McGlashan SR, Jensen CG, Poole CA. Localization of extracellular matrix receptors on the chondrocyte primary cilium. J Histochem Cytochem. 2006;54:1005–14.
Article CAS PubMed Google Scholar
Ivaska J, Heino J. Cooperation between integrins and growth factor receptors in signaling and endocytosis. Annu Rev Cell Dev Biol. 2011;27:291–320.
Article CAS PubMed Google Scholar
Mori S, Wu CY, Yamaji S, Saegusa J, Shi B, Ma Z, et al. Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. J Biol Chem. 2008;283:18066–75.
Article CAS PubMed PubMed Central Google Scholar
Praetorius HA, Spring KR. Bending the MDCK cell primary cilium increases intracellular calcium. J Membr Biol. 2001;184:71–9.
Article CAS PubMed Google Scholar
Praetorius HA, Spring KR. The renal cell primary cilium functions as a flow sensor. Curr Opin Nephrol Hypertens. 2003;12:517–20.
Hargreaves E, Jenks A, Staszewski A, Tsalikis A, Bodoque R, Arias-Garcia M, et al. Dysregulated SASS6 expression promotes increased ciliogenesis and cell invasion phenotypes. BioRXiv. 2024;doi: 2024.01.29.576599.
Williantarra I, Leung S, Choi YS, Chhana A, McGlashan SR. Chondrocyte-specific response to stiffness-mediated primary cilia formation and centriole positioning. Am J Physiol Cell Physiol. 2022;323:C236–C47.
Article CAS PubMed Google Scholar
Sasai N, Toriyama M, Kondo T. Hedgehog signal and genetic disorders. Front Genet. 2019;10:1103.
Article CAS PubMed PubMed Central Google Scholar
Hilgendorf KI, Myers BR, Reiter JF. Emerging mechanistic understanding of cilia function in cellular signalling. Nat Rev Mol Cell Biol. 2024;25:555–73.
Article CAS PubMed PubMed Central Google Scholar
Jing J, Wu Z, Wang J, Luo G, Lin H, Fan Y, et al. Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies. Signal Transduct Target Ther. 2023;8:315.
Article PubMed PubMed Central Google Scholar
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–74.
Comments (0)