SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71:209–49.

Article  PubMed  Google Scholar 

Iyengar P, Kavanagh BD, Wardak Z, Smith I, Ahn C, Gerber DE, et al. Phase II trial of stereotactic body radiation therapy combined with erlotinib for patients with limited but progressive metastatic non-small-cell lung cancer. J Clin Oncol. 2014;32:3824–30.

Article  PubMed  Google Scholar 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66:115–32.

Article  PubMed  Google Scholar 

Ramalingam SS, Owonikoko TK, Khuri FR. Lung cancer: New biological insights and recent therapeutic advances. CA Cancer J Clin. 2011;61:91–112.

Article  PubMed  Google Scholar 

Tanoue LT, Tanner NT, Gould MK, Silvestri GA. Lung cancer screening. Am J Respir Crit Care Med. 2015;191:19–33.

Article  PubMed  Google Scholar 

Wu X, Chen H, Wang X. Can lung cancer stem cells be targeted for therapies? Cancer Treat Rev. 2012;38:580–8.

Article  PubMed  Google Scholar 

Cao S, Wang Z, Gao X, He W, Cai Y, Chen H, et al. FOXC1 induces cancer stem cell-like properties through upregulation of beta-catenin in NSCLC. J Exp Clin Cancer Res. 2018;37:220.

Article  PubMed  PubMed Central  Google Scholar 

Deng K, Liu L, Tan X, Zhang Z, Li J, Ou Y, et al. WIP1 promotes cancer stem cell properties by inhibiting p38 MAPK in NSCLC. Signal Transduct Target Ther. 2020;5:36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Friedmann Angeli JP, Krysko DV, Conrad M. Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion. Nat Rev Cancer. 2019;19:405–14.

Article  CAS  PubMed  Google Scholar 

Elgendy SM, Alyammahi SK, Alhamad DW, Abdin SM, Omar HA. Ferroptosis: An emerging approach for targeting cancer stem cells and drug resistance. Crit Rev Oncol Hematol. 2020;155:103095.

Article  PubMed  Google Scholar 

Iwagawa T, Kawabata R, Fukushima M, Kuribayashi H, Watanabe S. Setd5, but not Setd2, is indispensable for retinal cell survival and proliferation. FEBS Lett. 2023;597:427–36.

Article  CAS  PubMed  Google Scholar 

Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, et al. Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature. 2003;421:652–6.

Article  CAS  PubMed  Google Scholar 

Piao L, Li H, Feng Y, Yang Z, Kim S, Xuan Y. SET domain-containing 5 is a potential prognostic biomarker that promotes esophageal squamous cell carcinoma stemness. Exp Cell Res. 2020;389:111861.

Article  CAS  PubMed  Google Scholar 

Yang Z, Zhang C, Liu X, Che N, Feng Y, Xuan Y. SETD5 Regulates Glycolysis in Breast Cancer Stem-Like Cells and Fuels Tumor Growth. Am J Pathol. 2022;192:712–21.

Article  CAS  PubMed  Google Scholar 

Yang Z, Zhang C, Che N, Feng Y, Li C, Xuan Y. Su(var)3-9, Enhancer of Zeste, and Trithorax Domain-Containing 5 Facilitates Tumor Growth and Pulmonary Metastasis through Up-Regulation of AKT1 Signaling in Breast Cancer. Am J Pathol. 2021;191:180–93.

Article  CAS  PubMed  Google Scholar 

Park M, Moon B, Kim JH, Park SJ, Kim SK, Park K, et al. Downregulation of SETD5 Suppresses the Tumorigenicity of Hepatocellular Carcinoma Cells. Mol Cells. 2022;45:550–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Q, Sun Z, Li J, Zhang D, Guo B, Zhang T. SET Domain-Containing Protein 5 Enhances the Cell Stemness of Non-Small Cell Lung Cancer via the PI3K/Akt/mTOR Pathway. J Environ Pathol Toxicol Oncol. 2021;40:55–63.

Article  PubMed  Google Scholar 

Yu H, Sun J, Zhao C, Wang H, Liu Y, Xiong J, et al. SET domain containing protein 5 (SETD5) enhances tumor cell invasion and is associated with a poor prognosis in non-small cell lung cancer patients. BMC Cancer. 2019;19:736.

Article  PubMed  PubMed Central  Google Scholar 

Wang Z, Hausmann S, Lyu R, Li TM, Lofgren SM, Flores NM, et al. SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy. Cancer Cell. 2020;37:834–49.e13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Osipovich AB, Gangula R, Vianna PG, Magnuson MA. Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation. Development. 2016;143:4595–607.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiao C, Fan T, Tian H, Zheng Y, Zhou Z, Li S, et al. H3K36 trimethylation-mediated biological functions in cancer. Clin Epigenetics. 2021;13:199.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen XY, Zhang J, Zhu JS. The role of m6A RNA methylation in human cancer. Mol Cancer. 2019;18:103.

Article  PubMed  PubMed Central  Google Scholar 

Cao G, Li HB, Yin Z, Flavell RA. Recent advances in dynamic m6A RNA modification. Open Biol. 2016;6:160003.

Article  PubMed  PubMed Central  Google Scholar 

Lan Q, Liu PY, Haase J, Bell JL, Hüttelmaier S, Liu T. The Critical Role of RNA m6A Methylation in Cancer. Cancer Res. 2019;79:1285–92.

Article  CAS  PubMed  Google Scholar 

Huang H, Weng H, Zhou K, Wu T, Zhao BS, Sun M, et al. Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally. Nature. 2019;567:414–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Qiu C, Bian Y, Shi D, Wang B, Ma Q, et al. SETD5 modulates homeostasis of hematopoietic stem cells by mediating RNA polymerase II pausing in cooperation with HCF-1. Leukemia. 2022;36:1111–22.

Article  CAS  PubMed  Google Scholar 

Che N, Li M, Liu X, Cui CA, Gong J, Xuan Y. Macelignan prevents colorectal cancer metastasis by inhibiting M2 macrophage polarization. Phytomedicine. 2024;122:155144.

Article  CAS  PubMed  Google Scholar 

Zhou Y, Zeng P, Li YH, Zhang Z, Cui Q. SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features. Nucleic Acids Res. 2016;44:e91.

Article  PubMed  PubMed Central  Google Scholar 

Yu H, Zhao K, Zeng H, Li Z, Chen K, Zhang Z, et al. N6-methyladenosine (m6A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability. Biomed Pharmacother. 2021;133:111075.

Article  CAS  PubMed  Google Scholar 

Yu SE, Kim MS, Park SH, Yoo BC, Kim KH, Jang YK. SET domain-containing protein 5 is required for expression of primordial germ cell specification-associated genes in murine embryonic stem cells. Cell Biochem Funct. 2017;35:247–53.

Article  CAS  PubMed  Google Scholar 

Pierce GB. The cancer cell and its control by the embryo. Rous-Whipple Award lecture. Am J Pathol. 1983;113:117–24.

CAS  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif