Pan L, Lu MP, Wang JH, Xu M, Yang SR. Immunological pathogenesis and treatment of systemic lupus erythematosus. World J Pediatrics: WJP Feb. 2020;16(1):19–30.

Article  Google Scholar 

Siegel CH, Sammaritano LR. Systemic lupus erythematosus: A review. Jama May. 2024;7(17):1480–91.

Article  Google Scholar 

Lazar S, Kahlenberg JM. Systemic lupus erythematosus: new diagnostic and therapeutic approaches. Annu Rev Med Jan. 2023;27:74:339–52.

Article  Google Scholar 

Xu H, Zhang X, Wang X, et al. Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity. Immun Aug. 2024;13(8):1796–e18111798.

Article  Google Scholar 

Peyronel F, Rossi GM, Palazzini G, et al. Early-onset lupus nephritis. Clin Kidney J Aug. 2024;17(8):sfae212.

Article  CAS  Google Scholar 

Geng W, Zhang S, Cao J, et al. Predictive factors of psychiatric syndrome in patients with systemic lupus erythematosus. Front Immunol. 2024;15:1323209.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Psarras A, Wittmann M, Vital EM. Emerging concepts of type I interferons in SLE pathogenesis and therapy. Nat Rev Rheumatol Oct. 2022;18(10):575–90.

CAS  Google Scholar 

Zhou Y, Song HM. Type I interferon pathway in pediatric systemic lupus erythematosus. World J Pediatr Jul. 2024;20(7):653–68.

Article  CAS  Google Scholar 

Qin Y, Ma J, Vinuesa CG. Monogenic lupus: insights into disease pathogenesis and therapeutic opportunities. Curr Opin Rheumatol May. 2024;1(3):191–200.

Article  Google Scholar 

Postal M, Vivaldo JF, Fernandez-Ruiz R, Paredes JL, Appenzeller S, Niewold TB. Type I interferon in the pathogenesis of systemic lupus erythematosus. Curr Opin Immunol Dec. 2020;67:87–94.

Article  CAS  Google Scholar 

Arish M, Sun J. Monocyte and macrophage function in respiratory viral infections. Anim Dis 2023/09/14. 2023;3(1):30.

Article  Google Scholar 

Shen M, Duan C, Xie C, et al. Identification of key interferon-stimulated genes for indicating the condition of patients with systemic lupus erythematosus. Front Immunol. 2022;13:962393.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perez RK, Gordon MG, Subramaniam M, et al. Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus. Sci (New York N Y) Apr. 2022;8(6589):eabf1970.

Article  Google Scholar 

Carter LM, Wigston Z, Laws P, Vital EM. Rapid efficacy of anifrolumab across multiple subtypes of recalcitrant cutaneous lupus erythematosus parallels changes in discrete subsets of blood transcriptomic and cellular biomarkers. Br J Dermatol Jul. 2023;17(2):210–8.

Article  Google Scholar 

Lv F, He Y, Xu H, et al. CD36 aggravates podocyte injury by activating NLRP3 inflammasome and inhibiting autophagy in lupus nephritis. Cell Death Disease Aug. 2022;23(8):729.

Article  Google Scholar 

Tsai CY, Li KJ, Shen CY et al. Decipher the immunopathological mechanisms and set up potential therapeutic strategies for patients with lupus nephritis. Int J Mol Sci Jun 13 2023;24(12).

Kong R, Sun L, Li H, Wang D. The role of NLRP3 inflammasome in the pathogenesis of rheumatic disease. Autoimmun Feb. 2022;55(1):1–7.

Article  CAS  Google Scholar 

Zhang Y, Liao Y, Hang Q, Sun D, Liu Y. GBP2 acts as a member of the interferon signalling pathway in lupus nephritis. BMC Immunol Sep. 2022;17(1):44.

Article  Google Scholar 

Liu N, Gao Y, Liu Y, Liu D. GBP5 Inhibition ameliorates the progression of lupus nephritis by suppressing NLRP3 inflammasome activation. Immunological Investigations Sep. 2022;29:1–15.

Google Scholar 

Liu J, Zhang X, Cao X. Dendritic cells in systemic lupus erythematosus: from pathogenesis to therapeutic applications. J Autoimmun Oct. 2022;132:102856.

Article  CAS  Google Scholar 

Nehar-Belaid D, Hong S, Marches R, et al. Mapping systemic lupus erythematosus heterogeneity at the single-cell level. Nat Immunol Sep. 2020;21(9):1094–106.

Article  CAS  Google Scholar 

Wang G, Tao H, Zhou L, et al. scRNA-seq reveals involvement of monocytes in immune response in SLE patients. Genomics Jan. 2025;14(2):110994.

Article  Google Scholar 

Sarin KY, Zheng H, Chaichian Y et al. Impaired innate and adaptive immune responses to BNT162b2 SARS-CoV-2 vaccination in systemic lupus erythematosus. JCI Insight Mar 8 2024;9(5).

Honardoost MA, Adinatha A, Schmidt F, et al. Systematic immune cell dysregulation and molecular subtypes revealed by single-cell RNA-seq of subjects with type 1 diabetes. Genome Med Mar. 2024;27(1):45.

Article  Google Scholar 

Kolde R, Laur S, Adler P, Vilo J. Robust rank aggregation for gene list integration and meta-analysis. Bioinf (Oxford England) Feb. 2012;15(4):573–80.

Google Scholar 

Butler A, Hoffman P, Smibert P, Papalexi E, Satija R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat Biotechnol Jun. 2018;36(5):411–20.

Article  CAS  Google Scholar 

Aran D, Looney AP, Liu L, et al. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol Feb. 2019;20(2):163–72.

Article  CAS  Google Scholar 

Love MI, Huber W, Anders S. Moderated Estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550.

Article  PubMed  PubMed Central  Google Scholar 

Ritchie ME, Phipson B, Wu D, et al. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res Apr. 2015;20(7):e47.

Article  Google Scholar 

Van de Sande B, Flerin C, Davie K, et al. A scalable SCENIC workflow for single-cell gene regulatory network analysis. Nat Protoc Jul. 2020;15(7):2247–76.

Article  Google Scholar 

Hänzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinf Jan. 2013;16:14:7.

Article  Google Scholar 

Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci United States Am Oct. 2005;25(43):15545–50.

Article  Google Scholar 

Huang W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nature protocols. 2009;4(1):44–57.

Spidlen J, Breuer K, Rosenberg C, Kotecha N, Brinkman RR. FlowRepository: a resource of annotated flow cytometry datasets associated with peer-reviewed publications. Cytometry Part A: J Int Soc Anal Cytol Sep. 2012;81(9):727–31.

Article  Google Scholar 

Mokbel A, Fouad NA, Alkemary A, Abdo M. Disease activity at the onset of diagnosis as a predictor of disease outcomes in a cohort of patients with systemic lupus erythematosus: A post hoc retrospective analysis of the COMOSLE-EGYPT study. Clin Rheumatol Jan. 2025;44(1):229–35.

Article  Google Scholar 

Gladman DD, Ibañez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol Feb. 2002;29(2):288–91.

Google Scholar 

Ambler WG, Kaplan MJ. Vascular damage in systemic lupus erythematosus. Nat Rev Nephrol Apr. 2024;20(4):251–65.

Article  CAS  Google Scholar 

Waterman HR, Dufort MJ, Posso SE, et al. Lupus IgA1 autoantibodies synergize with IgG to enhance plasmacytoid dendritic cell responses to RNA-containing immune complexes. Sci Transl Med Jul. 2024;3(754):eadl3848.

Article  Google Scholar 

Infante B, Mercuri S, Dello Strologo A et al. Unraveling the link between Interferon-α and systemic lupus erythematosus: from the molecular mechanisms to target therapies. Int J Mol Sci Dec 15 2022;23(24).

Xu Y, Li P, Li K, et al. Pathological mechanisms and crosstalk among different forms of cell death in systemic lupus erythematosus. J Autoimmun Oct. 2022;132:102890.

Article  CAS  Google Scholar 

Sim TM, Ong SJ, Mak A, Tay SH. Type I interferons in systemic lupus erythematosus: A journey from bench to bedside. Int J Mol Sci Feb 24 2022;23(5).

Sandling JK, Pucholt P, Hultin Rosenberg L, et al. Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing. Annals Rheumatic Dis Jan. 2021;80(1):109–17.

Article  CAS  Google Scholar 

Zhang Y, Wang J, Fang Y, et al. IFN-α affects Th17/Treg cell balance through c-Maf and associated with the progression of EBV- SLE. Mol Immunol Jul. 2024;171:22–35.

Article  CAS  Google Scholar 

Kiefer K, Oropallo MA, Cancro MP, Marshak-Rothstein A. Role of type I interferons in the activation of autoreactive B cells. Immunol Cell Biology May. 2012;90(5):498–504.

Article  CAS  Google Scholar 

Swiecki M, Colonna M. The multifaceted biology of plasmacytoid dendritic cells. Nat Rev Immunol Aug. 2015;15(8):471–85.

Article  CAS  Google Scholar 

Alculumbre S, Raieli S, Hoffmann C, Chelbi R, Danlos FX, Soumelis V. Plasmacytoid pre-dendritic cells (pDC): from molecular pathways t