Stern J, Pier J, Litonjua AA. Asthma epidemiology and risk factors. Semin Immunopathol. 2020;42:5–15. https://doi.org/10.1007/s00281-020-00785-1
Ramírez-Marín HA, Silverberg JI. Differences between pediatric and adult atopic dermatitis. Pediatr Dermatol. 2022;39:345–53. https://doi.org/10.1111/pde.14971
Yaneva M, Darlenski R. The link between atopic dermatitis and asthma- immunological imbalance and beyond. Asthma Res Pract. 2021;7:16. https://doi.org/10.1186/s40733-021-00082-0
Article PubMed PubMed Central Google Scholar
Silva N, Carona C, Crespo C, Canavarro MC. Quality of life in pediatric asthma patients and their parents: a meta-analysis on 20 years of research. Expert Rev Pharmacoecon Outcomes Res. 2015;15:499–519. https://doi.org/10.1586/14737167.2015.1008459
Blome C, Radtke MA, Eissing L, Augustin M. Quality of life in patients with atopic dermatitis: disease burden, measurement, and treatment benefit. Am J Clin Dermatol. 2016;17:163–9. https://doi.org/10.1007/s40257-015-0171-3
Ali F, Vyas J, Finlay AY. Counting the burden: atopic dermatitis and health-related quality of life. Acta Derm Venereol. 2020;100:adv00161. https://doi.org/10.2340/00015555-3511
Eslambeik T, Pourvali A, Ghandi Y, Alaghmand A, Zamanian M, Tajerian A. Quality of life in children with asthma compared to healthy children: a case-control study. J Asthma. 2023;60:1942–50. https://doi.org/10.1080/02770903.2023.2200852
Article CAS PubMed Google Scholar
Kisieliene I, Mainelis A, Rudzeviciene O, Bylaite-Bucinskiene M, Wollenberg A. The burden of pediatric atopic dermatitis: quality of life of patients and their families. JCM. 2024. https://doi.org/10.3390/jcm13061700
Article PubMed PubMed Central Google Scholar
Yang EJ, Beck KM, Sekhon S, Bhutani T, Koo J. The impact of pediatric atopic dermatitis on families: a review. Pediatr Dermatol. 2019;36:66–71. https://doi.org/10.1111/pde.13727
Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Nationale VersorgungsLeitlinie Asthma – Langfassung, 4th ed. Version 1. 2020. https://doi.org/10.6101/AZQ/000469
Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol. 2018;32:657–82. https://doi.org/10.1111/jdv.14891
Article CAS PubMed Google Scholar
Agache I, Akdis CA, Akdis M, Brockow K, Chivato T, Del Giacco S, et al. EAACI biologicals guidelines-dupilumab for children and adults with moderate-to-severe atopic dermatitis. Allergy. 2021;76:988–1009. https://doi.org/10.1111/all.14690
Werfel T, Aberer W, Ahrens F, Augustin M, Biedermann T, Diepgen T, et al. S3-Leitlinie Atopische dermatitis (AD) [Neurodermitis; atopisches Ekzem]. Deutsche Dermatologische Gesellschaft e.V. (DDG); 2023.
Patel NU, D’Ambra V, Feldman SR. Increasing adherence with topical agents for atopic dermatitis. Am J Clin Dermatol. 2017;18:323–32. https://doi.org/10.1007/s40257-017-0261-5
Desager K, Vermeulen F, Bodart E. Adherence to asthma treatment in childhood and adolescence - a narrative literature review. Acta Clin Belg. 2018;73:348–55. https://doi.org/10.1080/17843286.2017.1409684
Conroy ER, Banzon TM, Simoneau T, Phipatanakul W, van Boven JFM, Larenas-Linnemann D. An overview of adherence-what it is and why it is important. J Allergy Clin Immunol Pract. 2024;12:3180–8. https://doi.org/10.1016/j.jaip.2024.07.018
Article CAS PubMed Google Scholar
Kosse RC, Bouvy ML, Daanen M, de Vries TW, Koster ES. Adolescents’ perspectives on atopic dermatitis treatment—experiences, preferences, and beliefs. JAMA Dermatol. 2018;154:824. https://doi.org/10.1001/jamadermatol.2018.1096
Article PubMed PubMed Central Google Scholar
Haktanir Abul M, Phipatanakul W. Severe asthma in children: evaluation and management. Allergol Int. 2019;68:150–7. https://doi.org/10.1016/j.alit.2018.11.007
Article CAS PubMed Google Scholar
Harb H, Chatila TA. Mechanisms of dupilumab. Clin Exp Allergy. 2020;50:5–14. https://doi.org/10.1111/cea.13491
Article CAS PubMed Google Scholar
Paller AS, Siegfried EC, Thaçi D, Wollenberg A, Cork MJ, Arkwright PD, et al. Efficacy and safety of dupilumab with concomitant topical corticosteroids in children 6 to 11 years old with severe atopic dermatitis: a randomized, double-blinded, placebo-controlled phase 3 trial. J Am Acad Dermatol. 2020;83:1282–93. https://doi.org/10.1016/j.jaad.2020.06.054
Article CAS PubMed Google Scholar
Simpson EL, Paller AS, Siegfried EC, Boguniewicz M, Sher L, Gooderham MJ, et al. Efficacy and safety of dupilumab in adolescents with uncontrolled moderate to severe atopic dermatitis: a phase 3 randomized clinical trial. JAMA Dermatol. 2020;156:44–56. https://doi.org/10.1001/jamadermatol.2019.3336
William W, Busse JF, Maspero, Klaus F, Rabe A, Papi SE, Wenzel LB, Ford, et al. Liberty asthma QUEST: phase 3 randomized, Double-Blind, Placebo-Controlled, Parallel-Group study to evaluate dupilumab efficacy/safety in patients with uncontrolled. Moderate-to-Severe Asthma: Adis Journals; 2018.
Wollenberg A, Marcoux D, Silverberg JI, Aoki V, Baselga E, Zhang H, et al. Dupilumab provides rapid and sustained improvement in scoring atopic dermatitis outcomes in paediatric patients with atopic dermatitis. Acta Derm Venereol. 2022;102:adv00726. https://doi.org/10.2340/actadv.v102.854
Article CAS PubMed Google Scholar
Fiocchi AG, Phipatanakul W, Zeiger RS, Durrani SR, Cole J, Msihid J, et al. Dupilumab leads to better-controlled asthma and quality of life in children: the VOYAGE study. Eur Respir J. 2023. https://doi.org/10.1183/13993003.00558-2023
Article PubMed PubMed Central Google Scholar
Ciprandi G, Licari A, Tosca MA, Del Miraglia Giudice M, Belloni Fortina A, Marseglia GL. An updated reappraisal of dupilumab in children and adolescents with moderate-severe atopic dermatitis. Pediatr Allergy Immunol. 2024;35:e14181. https://doi.org/10.1111/pai.14181
Article CAS PubMed Google Scholar
Paller AS, Silverberg JI, Simpson EL, Cork MJ, Arkwright PD, Chen Z, et al. The effect of dupilumab on caregiver- and patient-reported outcomes in young children with moderate-to-severe atopic dermatitis: results from a placebo-controlled, phase 3 study. J Am Acad Dermatol. 2025;92:116–26. https://doi.org/10.1016/j.jaad.2024.09.039
Article CAS PubMed Google Scholar
Dhar S, De A, Srinivas SM. Real-world effectiveness and safety of dupilumab for the treatment of moderate to severe atopic dermatitis in Indian patients: a multi centric retrospective study. Indian J Dermatol. 2021;66:297–301. https://doi.org/10.4103/ijd.ijd_860_20
Article PubMed PubMed Central Google Scholar
Yang D-Y, Li L, Lu T, Jing W-W, Liu X, Li X-L. Efficacy and safety of dupilumab in pediatric patients with moderate to severe atopic dermatitis: a real-world study. Arch Dermatol Res. 2023;315:467–72. https://doi.org/10.1007/s00403-022-02380-w
Article CAS PubMed Google Scholar
Patruno C, Fabbrocini G, Lauletta G, Boccaletti V, Colonna C, Cavalli R, et al. A 52-week multicenter retrospective real-world study on effectiveness and safety of dupilumab in children with atopic dermatitis aged from 6 to 11 years. J Dermatolog Treat. 2023;34:2246602. https://doi.org/10.1080/09546634.2023.2246602
Article CAS PubMed Google Scholar
Napolitano M, Fabbrocini G, Potestio L, Fontanella G, Picone V, Bennardo L, et al. A 24-weeks real-world experience of dupilumab in adolescents with moderate-to-severe atopic dermatitis. Dermatol Ther. 2022;35:e15588. https://doi.org/10.1111/dth.15588
Article CAS PubMed Google Scholar
Pagan AD, David E, Ungar B, Ghalili S, He H, Guttman-Yassky E. Dupilumab improves clinical scores in children and adolescents with moderate to severe atopic dermatitis: a real-world, single-center study. J Allergy Clin Immunol Pract. 2022;10:2378–85. https://doi.org/10.1016/j.jaip.2022.06.014
Comments (0)