Structure–function insights of natural polysaccharides: advances in biosynthesis and functional food applications

Wu S, Zhang S, Peng B, Tan D, Wu M, Wei J, et al. Ganoderma lucidum: a comprehensive review of phytochemistry, efficacy, safety and clinical study. Food Sci Hum Wellness. 2024;13(2):568–96. https://doi.org/10.26599/FSHW.2022.9250051.

Article  CAS  Google Scholar 

Zeng P, Guo Z, Zeng X, Hao C, Zhang Y, Zhang M, et al. Ganoderma lucidum polysaccharide: chemical, biochemical, preclinical and clinical studies as an approved drug for treating myopathy and other diseases in China. J Cell Mol Med. 2018;22(7):3278–97. https://doi.org/10.1111/jcmm.13613.

Article  PubMed  PubMed Central  Google Scholar 

Zhang J, Liu Y, Tang Q, Zhou S, Feng J, Chen H. Polysaccharide of Ganoderma and its bioactivities. In: Lin Z, Yang B, editors. Ganoderma and Health: Biology, Chemistry and Industry. 2019. pp. 107–134.

Hsu K, Cheng K. From nutraceutical to clinical trial: frontiers in Ganoderma development. Appl Microbiol Biotechnol. 2018;102(21):9037–51. https://doi.org/10.1007/s00253-018-9326-5.

Article  CAS  PubMed  Google Scholar 

Seweryn E, Ziala A, Gamian A. Health-promoting of polysaccharides extracted from Ganoderma lucidum. Nutrients. 2021. https://doi.org/10.3390/nu13082725.

Article  PubMed  PubMed Central  Google Scholar 

Sulkowska-Ziaja K, Balik M, Szczepkowski A, Trepa M, Zengin G, Kala K, et al. A review of chemical composition and bioactivity studies of the most promising species of Ganoderma spp. Diversity. 2023. https://doi.org/10.3390/d15080882.

Article  Google Scholar 

Leong YK, Yang F-C, Chang J-S. Extraction of polysaccharides from edible mushrooms: emerging technologies and recent advances. Carbohydr Polym. 2021;251: 117006. https://doi.org/10.1016/j.carbpol.2020.117006.

Article  CAS  PubMed  Google Scholar 

Liu Y, Tang Q, Zhang J, Xia Y, Yang Y, Wu D, et al. Triple helix conformation of β-d-glucan from Ganoderma lucidum and effect of molecular weight on its immunostimulatory activity. Int J Biol Macromol. 2018;114:1064–70. https://doi.org/10.1016/j.ijbiomac.2018.03.054.

Article  CAS  PubMed  Google Scholar 

Lu J, He R, Sun P, Zhang F, Linhardt RJ, Zhang A. Molecular mechanisms of bioactive polysaccharides from Ganoderma lucidum (Lingzhi), a review. Int J Biol Macromol. 2020;150:765–74. https://doi.org/10.1016/j.ijbiomac.2020.02.035.

Article  CAS  PubMed  Google Scholar 

Zhang Z, Cui F, Sun L, Zan X, Sun W. Recent advances in Ganoderma lucidum polysaccharides: structures/bioactivities, biosynthesis and regulation. Food Biosci. 2023;56: 103281. https://doi.org/10.1016/j.fbio.2023.103281.

Article  CAS  Google Scholar 

Zheng M, Pi X, Li H, Cheng S, Su Y, Zhang Y, et al. Ganoderma spp. polysaccharides are potential prebiotics: a review. Crit Rev Food Sci Nutr. 2024;64(4):909–27. https://doi.org/10.1080/10408398.2022.2110035.

Article  CAS  PubMed  Google Scholar 

Qin X, Fang Z, Zhang J, Zhao W, Zheng N, Wang X. Regulatory effect of Ganoderma lucidum and its active components on gut flora in diseases. Front Microbiol. 2024;15:1362479. https://doi.org/10.3389/fmicb.2024.1362479.

Article  PubMed  PubMed Central  Google Scholar 

Zhang H, Zhang J, Liu Y, Tang C. Recent advances in the preparation, structure, and biological activities of β-glucan from Ganoderma species: a review. Foods. 2023;12(15):12975. https://doi.org/10.3390/foods12152975.

Article  CAS  Google Scholar 

Ye T, Ge Y, Jiang X, Song H, Peng C, Liu B. A review of anti-tumour effects of Ganoderma lucidum in gastrointestinal cancer. Chin Med. 2023;18(1):811. https://doi.org/10.1186/s13020-023-00811-y.

Article  Google Scholar 

Ahmad MF, Ahmad FA, Zeyaullah M, Alsayegh AA, Mahmood SE, AlShahrani AM, et al. Ganoderma lucidum: novel insight into hepatoprotective potential with mechanisms of action. Nutrients. 2023;15(8):1874. https://doi.org/10.3390/nu15081874.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andrejc DC, Knez Z, Marevci MK. Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and neuro-protective activity of Ganoderma lucidum: an overview. Front Pharmacol. 2022;13: 934982. https://doi.org/10.3389/fphar.2022.934982.

Article  CAS  Google Scholar 

Liu Y, Wu J, Hao H. Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma. Front Immunol. 2024;15:1369110. https://doi.org/10.3389/fimmu.2024.1369110.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahmad MF, Ahmad FA, Hasan N, Alsayegh AA, Hakami O, Bantun F, et al. Ganoderma lucidum: multifaceted mechanisms to combat diabetes through polysaccharides and triterpenoids: a comprehensive review. Int J Biol Macromol. 2024;268: 131644. https://doi.org/10.1016/j.ijbiomac.2024.131644.

Article  CAS  PubMed  Google Scholar 

Peng H, Zhong L, Cheng L, Chen L, Tong R, Shi J, et al. Ganoderma lucidum: current advancements of characteristic components and experimental progress in anti-liver fibrosis. Front Pharmacol. 2022;13:1094405. https://doi.org/10.3389/fphar.2022.1094405.

Article  CAS  PubMed  Google Scholar 

El Sheikha AF. Nutritional profile and health benefits of Ganoderma lucidum “Lingzhi, Reishi, or Mannentake” as functional foods: current scenario and future perspectives. Foods. 2022;11(7):1030. https://doi.org/10.3390/foods11071030.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma Y, He H, Wu J, Wang C, Chao K, Huang Q. Assessment of polysaccharides from mycelia of genus Ganoderma by mid-infrared and near-infrared spectroscopy. Sci Rep. 2018. https://doi.org/10.1038/s41598-017-18422-7.

Article  PubMed  PubMed Central  Google Scholar 

Skalicka-Woźniak K, Szypowski J, Łoś R, Siwulski M, Sobieralski K, Głowniak K, et al. Evaluation of polysaccharides content in fruit bodies and their antimicrobial activity of four Ganoderma lucidum (W Curt.: Fr.) P. Karst. strains culitvated on different wooden substrates. Acta Soc Bot Pol. 2012;81:17–21.

Article  Google Scholar 

Nakagawa T, Zhu Q, Tamrakar S, Amen Y, Mori Y, Suhara H, et al. Changes in content of triterpenoids and polysaccharides in Ganoderma lingzhi at different growth stages. J Nat Med. 2018;72(3):734–44. https://doi.org/10.1007/s11418-018-1213-y.

Article  CAS  PubMed  Google Scholar 

Xu A, Yang X, Li Y, Jacob MS, Zhang B, Li X. Fresh-eating Lingzhi becomes possible: comparative evaluation of nutritional and taste profile of Ganoderma tsugae at different fruiting body morphogenesis stages. LWT. 2024;201: 116234. https://doi.org/10.1016/j.lwt.2024.116234.

Article  CAS  Google Scholar 

Zheng W, Lan S, Zhang W, Nie B, Zhu K, Ye X, et al. Polysaccharide structure evaluation of Ganoderma lucidum from different regions in China based on an innovative extraction strategy. Carbohydr Polym. 2024;335: 122079. https://doi.org/10.1016/j.carbpol.2024.122079.

Article  CAS  PubMed  Google Scholar 

Liu Y, Long Y, Liu H, Lan Y, Long T, Kuang R, et al. Polysaccharide prediction in Ganoderma lucidum fruiting body by hyperspectral imaging. Food Chem X. 2022;13: 100199. https://doi.org/10.1016/j.fochx.2021.100199.

Article  CAS  PubMed  Google Scholar 

Guo Q, Liang S, Ge C, Xiao Z. Research progress on extraction technology and biological activity of polysaccharides from edible fungi: a review. Food Rev Int. 2023;39(8):4909–40. https://doi.org/10.1080/87559129.2022.2039182.

Article  CAS  Google Scholar 

Nguyen T, Ngo T, Do Dat T, Nguyen D, Hoang M, Mai P, et al. Effects of extraction technology on bioactivities from polysaccharide-rich Ganoderma lucidum. Minist Sci Technol Vietnam. 2022;64:32–7. https://doi.org/10.31276/VJST.64(11).32-37.

Article  Google Scholar 

Feng J, Feng N, Tang Q, Liu Y, Yang Y, Liu F, et al. Optimization of Ganoderma lucidum polysaccharides fermentation process for large-scale production. Appl Biochem Biotechnol. 2019;189:972–86. https://doi.org/10.1007/s12010-019-02968-5.

Article  CAS  PubMed  Google Scholar 

Lyu F, Xu X, Zhang L. Natural polysaccharides with different conformations: extraction, structure and anti-tumor activity. J Mater Chem B. 2020;8(42):9652–67. https://doi.org/10.1039/d0tb01713b.

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