Beloin-Saint-Pierre, D. & Hischier, R. Towards a more environmentally sustainable production of graphene-based materials. Int. J. Life Cycle Assess. 26, 327–343 (2021).

Article  CAS  Google Scholar 

Min, K., Cuiffi, J. D. & Mathers, R. T. Ranking environmental degradation trends of plastic marine debris based on physical properties and molecular structure. Nat. Commun. 11, 727 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chamas, A. et al. Degradation rates of plastics in the environment. ACS Sustain. Chem. Eng. 8, 3494–3511 (2020).

Article  CAS  Google Scholar 

Shukla, V., Stone, A., McGrath, M., Kane, A. & Hurt, R. Chemical degradation kinetics for two-dimensional materials in natural and biological environments – a data-driven review. Environ. Sci. Nano 9, 2297–2319 (2022).

Article  CAS  Google Scholar 

Li, L. H., Cervenka, J., Watanabe, K., Taniguchi, T. & Chen, Y. Strong oxidation resistance of atomically thin boron nitride nanosheets. ACS Nano 8, 1457–1462, (2014).

Article  CAS  PubMed  Google Scholar 

Li, Q., Zhou, Q., Shi, L., Chen, Q. & Wang, J. Recent advances in oxidation and degradation mechanisms of ultrathin 2D materials under ambient conditions and their passivation strategies. J. Mater. Chem. A 7, 4291–4312 (2019).

Article  CAS  Google Scholar 

Cao, F. et al. Recent advances in oxidation stable chemistry of 2D MXenes. Adv. Mater. 34, 2107554 (2022).

Article  CAS  Google Scholar 

Ma, B., Martín, C., Kurapati, R. & Bianco, A. Degradation-by-design: how chemical functionalization enhances the biodegradability and safety of 2D materials. Chem. Soc. Rev. 49, 6224–6247 (2020).

Article  CAS  PubMed  Google Scholar 

Kostarelos, K. & Novoselov, K. S. Exploring the interface of graphene and biology. Science 344, 261–263 (2014).

Article  CAS  PubMed  Google Scholar 

Kotchey, G. P. et al. The enzymatic oxidation of graphene oxide. ACS Nano 5, 2098–2108 (2011). This study demonstrates the biodegradation of graphene oxide catalysed by the plant peroxidase enzyme.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, M., Qin, X. & Zeng, G. Biodegradation of carbon nanotubes, graphene, and their derivatives. Trends Biotechnol. 35, 836–846 (2017).

Article  CAS  PubMed  Google Scholar 

Candotto Carniel, F. et al. Graphene environmental biodegradation: wood degrading and saprotrophic fungi oxidize few-layer graphene. J. Hazard. Mater. 414, 125553 (2021).

Article  CAS  PubMed  Google Scholar 

Li, Y. et al. Surface coating-dependent cytotoxicity and degradation of graphene derivatives: towards the design of non-toxic, degradable nano-graphene. Small 10, 1544–1554 (2014).

Article  CAS  PubMed  Google Scholar 

Rajendra, K. et al. Covalent chemical functionalization enhances the biodegradation of graphene oxide. 2D Mater. 5, 015020 (2018).

Google Scholar 

Kurapati, R. et al. Dispersibility-dependent biodegradation of graphene oxide by myeloperoxidase. Small 11, 3985–3994 (2015).

Article  CAS  PubMed  Google Scholar 

Kurapati, R., Martìn, C., Palermo, V., Nishina, Y. & Bianco, A. Biodegradation of graphene materials catalyzed by human eosinophil peroxidase. Faraday Discuss. 227, 189–203 (2021).

Article  CAS  PubMed  Google Scholar 

Lalwani, G., Xing, W. & Sitharaman, B. Enzymatic degradation of oxidized and reduced graphene nanoribbons by lignin peroxidase. J. Mater. Chem. B 2, 6354–6362 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kurapati, R. et al. Degradation of single-layer and few-layer graphene by neutrophil myeloperoxidase. Angew. Chem. Int. Ed. 57, 11722–11727 (2018).

Article  CAS  Google Scholar 

Luan, X. et al. Degradation of structurally defined graphene nanoribbons by myeloperoxidase and the photo-Fenton reaction. Angew. Chem. Int. Ed. 59, 18515–18521 (2020).

Article  CAS  Google Scholar 

He, X., Sorescu, D. C. & Star, A. Composition and structure of fluorescent graphene quantum dots generated by enzymatic degradation of graphene oxide. J. Phys. Chem. C 125, 13361–13369 (2021).

Article  CAS  Google Scholar 

Martín, C. et al. Enzymatic degradation of graphene quantum dots by human peroxidases. Small 15, 1905405 (2019).

Article  Google Scholar 

Kurapati, R. & Bianco, A. Peroxidase mimicking DNAzymes degrade graphene oxide. Nanoscale 10, 19316–19321 (2018).

Article  CAS  PubMed  Google Scholar 

Lee, H. et al. In vivo self-degradable graphene nanomedicine operated by DNAzyme and photo-switch for controlled anticancer therapy. Biomaterials 263, 120402 (2020).

Article  CAS  PubMed  Google Scholar 

Donskyi, I. S. et al. Self-degrading graphene sheets for tumor therapy. Nanoscale 12, 14222–14229 (2020).

Article  CAS  PubMed  Google Scholar 

Peng, G. et al. Biodegradation of graphdiyne oxide in classically activated (M1) macrophages modulates cytokine production. Nanoscale 13, 13072–13084 (2021).

Article  CAS  PubMed  Google Scholar 

Peng, G. et al. Nitric oxide-dependent biodegradation of graphene oxide reduces inflammation in the gastrointestinal tract. Nanoscale 12, 16730–16737 (2020).

Article  CAS  PubMed  Google Scholar 

Qi, Y. et al. The biotransformation of graphene oxide in lung fluids significantly alters its inherent properties and bioactivities toward immune cells. NPG Asia Mater. 10, 385–396 (2018).

Article  CAS  Google Scholar 

Hu, X., Li, D. & Mu, L. Biotransformation of graphene oxide nanosheets in blood plasma affects their interactions with cells. Environ. Sci. Nano 4, 1569–1578 (2017).

Article  CAS  Google Scholar 

Zhu, J. et al. Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium. Environ. Pollut. 306, 119421 (2022).

Article  CAS  PubMed  Google Scholar 

Guarnieri, D. et al. Biotransformation and biological interaction of graphene and graphene oxide during simulated oral ingestion. Small 14, 1800227 (2018).

Article  Google Scholar 

Bitounis, D. et al. Synthesis and physicochemical transformations of size-sorted graphene oxide during simulated digestion and its toxicological assessment against an in vitro model of the human intestinal epithelium. Small 16, 1907640 (2020).

Article  CAS  Google Scholar 

Fan, T. et al. Biodistribution, degradability and clearance of 2D materials for their biomedical applications. Chem. Soc. Rev. 51, 7732–7751 (2022).

Article  CAS  PubMed  Google Scholar 

Kucki, M. et al. Interaction of graphene-related materials with human intestinal cells: an in vitro approach. Nanoscale 8, 8749–8760 (2016).

Article  CAS  PubMed  Google Scholar 

Kurapati, R. et al. Enzymatic biodegradability of pristine and functionalized transition metal dichalcogenide MoS2 nanosheets. Adv. Funct. Mater. 27, 1605176 (2017).

Article  Google Scholar 

Kurapati, R., Backes, C., Ménard-Moyon, C., Coleman, J. N. & Bianco, A. White graphene undergoes peroxidase degradation. Angew. Chem. Int. Ed. 55, 5506–5511, (2016).

Article  CAS