Clinical, biological, electrophysiological and therapeutic profile of patients with anti-MAG neuropathy according to MYD88L265P and CXCR4 mutations and underlying haemopathy

Svahn J, Petiot P, Antoine JC, Vial C, Delmont E, Viala K, Steck AJ, Magot A, Cauquil C, Zarea A, Echaniz-Laguna A, IancuFerfoglia R, Gueguen A, Magy L, Léger JM, Kuntzer T, Ferraud K, Lacour A, Camdessanché JP, Francophone Anti-MAG cohort Group (2018) Anti-MAG antibodies in 202 patients: clinicopathological and therapeutic features. J Neurol Neurosurg Psychiatry 89(5):499–505. https://doi.org/10.1136/jnnp-2017-316715

Article  PubMed  Google Scholar 

Nobile-Orazio E, Meucci N, Baldini L, Di Troia A, Scarlato G (2000) Long-term prognosis of neuropathy associated with anti-MAG IgM M-proteins and its relationship to immune therapies. Brain 123(Pt 4):710–717. https://doi.org/10.1093/brain/123.4.710

Article  PubMed  Google Scholar 

Léger JM, Viala K, Nicolas G, Créange A, Vallat JM, Pouget J, Clavelou P, Vial C, Steck A, Musset L, Marin B, RIMAG Study Group (France and Switzerland) (2013) Placebo-controlled trial of rituximab in IgM anti-myelin-associated glycoprotein neuropathy. Neurology 80(24):2217–2225. https://doi.org/10.1212/WNL.0b013e318296e92b

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dalakas MC, Rakocevic G, Salajegheh M, Dambrosia JM, Hahn AF, Raju R, McElroy B (2009) Placebo-controlled trial of rituximab in IgM anti-myelin-associated glycoprotein antibody demyelinating neuropathy. Ann Neurol 65(3):286–293. https://doi.org/10.1002/ana.21577

Article  CAS  PubMed  Google Scholar 

Steck AJ (2021) Anti-MAG neuropathy: from biology to clinical management. J Neuroimmunol 361:577725. https://doi.org/10.1016/j.jneuroim.2021.577725

Article  CAS  PubMed  Google Scholar 

Jimenez C, Sebastian E, Chillon MC, Giraldo P, Mariano Hernandez J, Escalante F et al (2013) MYD88 L265P is a marker highly characteristic of, but not restricted to. Waldenstrom’s Macroglobulinemia. Leukemia 27:1722–1728

Article  CAS  PubMed  Google Scholar 

Landgren O (2021) Advances in MGUS diagnosis, risk stratification, and management: introducing myeloma-defining genomic events. Hematology 2021(1):662–672. https://doi.org/10.1182/hematology.2021000303.PMID:34889381;PMCID:PMC8791104

Article  PubMed  PubMed Central  Google Scholar 

Jiménez C, Sebastián E, Chillón MC et al (2013) MYD88 L265P is a marker highly characteristic of, but not restricted to. Waldenström’s macroglobulinemia. Leukemia 27(8):1722–1728

Article  PubMed  Google Scholar 

Castillo JJ, Moreno DF, Arbelaez MI, Hunter ZR, Treon SP (2019) CXCR4 mutations affect presentation and outcomes in patients with Waldenström macroglobulinemia: a systematic review. Expert Rev Hematol 12(10):873–881. https://doi.org/10.1080/17474086.2019.1649132

Article  CAS  PubMed  Google Scholar 

Landgren O, Tageja N (2014) MYD88 and beyond: novel opportunities for diagnosis, prognosis and treatment in Waldenström’s Macroglobulinemia. Leukemia 28(9):1799–1803. https://doi.org/10.1038/leu.2014.88

Article  CAS  PubMed  Google Scholar 

Varettoni M, Zibellini S, Defrancesco I, Ferretti V, Rizzo E, Malcovati L et al (2017) Pattern of somatic mutations in patients with Waldenström macroglobulinemia or IgM monoclonal gammopathy of undetermined significance. Haematologica. https://doi.org/10.3324/haematol.2017.172718

Article  PubMed  PubMed Central  Google Scholar 

Joint Task Force of the EFNS and the PNS (2010) European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of paraproteinemic demyelinating neuropathies. Report of a Joint Task Force of the European Federation of Neurological Societies and the Peripheral Nerve Society—first revision. J Peripher Nerv Syst 15:185–195

Article  Google Scholar 

Athanasopoulos D, Motte J, Grüter T, Köse N, Yoon MS, Otto S, Schneider-Gold C, Gold R, Fisse AL, Pitarokoili K (2021) Evaluation of the EFNS/PNS diagnostic criteria in a cohort of CIDP patients. Ann Clin Transl Neurol 8(5):1110–1121. https://doi.org/10.1002/acn3.51357

Article  CAS  PubMed  PubMed Central  Google Scholar 

Merkies IS, Schmitz PI, van der Meché FG, van Doorn PA (2000) Psychometric evaluation of a new sensory scale in immune-mediated polyneuropathies. Inflammatory Neuropathy Cause and Treatment (INCAT) Group. Neurology 54(4):943–949. https://doi.org/10.1212/wnl.54.4.943

Article  CAS  PubMed  Google Scholar 

Van Nes SI, Vanhoutte EK, van Doorn PA, Hermans M, Bakkers M, Kuitwaard K, Faber CG, Merkies IS (2011) Rasch-built Overall Disability Scale (R-ODS) for immune-mediated peripheral neuropathies. Neurology 76(4):337–345. https://doi.org/10.1212/WNL.0b013e318208824b

Article  PubMed  Google Scholar 

Graham RC, Hughes RA (2006) A modified peripheral neuropathy scale: the Overall Neuropathy Limitations Scale. J Neurol Neurosurg Psychiatry 77(8):973–976. https://doi.org/10.1136/jnnp.2005.081547

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, Bejar R, Berti E, Busque L, Chan JKC, Chen W, Chen X, Chng WJ, Choi JK, Colmenero I, Coupland SE, Cross NCP, De Jong D, Elghetany MT, Takahashi E, Emile JF, Ferry J, Fogelstrand L, Fontenay M, Germing U, Gujral S, Haferlach T, Harrison C, Hodge JC, Hu S, Jansen JH, Kanagal-Shamanna R, Kantarjian HM, Kratz CP, Li XQ, Lim MS, Loeb K, Loghavi S, Marcogliese A, Meshinchi S, Michaels P, Naresh KN, Natkunam Y, Nejati R, Ott G, Padron E, Patel KP, Patkar N, Picarsic J, Platzbecker U, Roberts I, Schuh A, Sewell W, Siebert R, Tembhare P, Tyner J, Verstovsek S, Wang W, Wood B, Xiao W, Yeung C, Hochhaus A (2022) The 5th World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic/dendritic neoplasms. Leukemia 36(7):1703–1719. https://doi.org/10.1038/s41375-022-01613-1

Article  PubMed  PubMed Central  Google Scholar 

Varettoni M, Arcaini L, Zibellini S, Boveri E, Rattotti S, Riboni R, Corso A, Orlandi E, Bonfichi M, Gotti M, Pascutto C, Mangiacavalli S, Croci G, Fiaccadori V, Morello L, Guerrera ML, Paulli M, Cazzola M (2013) Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom’s macroglobulinemia and related lymphoid neoplasms. Blood 121(13):2522–2528. https://doi.org/10.1182/blood-2012-09-457101

Article  CAS  PubMed  Google Scholar 

Feng R, Zhao J, Sun F, Miao M, Sun X, He J, Li Z (2022) Comparison of the deep immune profiling of B cell subsets between healthy adults and Sjögren’s syndrome. Ann Med 54(1):472–483. https://doi.org/10.1080/07853890.2022.2031272

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berrón-Ruíz L, López-Herrera G, Ávalos-Martínez CE, Valenzuela-Ponce C, Ramírez-San Juan E, Santoyo-Sánchez G, MújicaGuzmán F, Espinosa-Rosales FJ, Santos-Argumedo L (2016) Variations of B cell subpopulations in peripheral blood of healthy Mexican population according to age: relevance for diagnosis of primary immunodeficiencies. Allergol Immunopathol (Madr) 44(6):571–579. https://doi.org/10.1016/j.aller.2016.05.003

Article  PubMed  Google Scholar 

Attarian S, Azulay JP, Boucraut J, Escande N, Pouget J (2001) Terminal latency index and modified F ratio in distinction of chronic demyelinating neuropathies. Clin Neurophysiol 112(3):457–463. https://doi.org/10.1016/s1388-2457(01)00469-2

Article  CAS  PubMed  Google Scholar 

Fatehi F, Delmont E, Grapperon AM, Salort-Campana E, Sévy A, Verschueren A, Boucraut J, Attarian S (2017) Motor unit number index (MUNIX) in patients with anti-MAG neuropathy. Clin Neurophysiol 128(7):1264–1269. https://doi.org/10.1016/j.clinph.2017.04.022

Article  PubMed  Google Scholar 

van Schaik IN, Bril V, van Geloven N, Hartung HP, Lewis RA, Sobue G, Lawo JP, Praus M, Mielke O, Durn BL, Cornblath DR, Merkies ISJ, PATH Study Group (2018) Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Neurol 17(1):35–46. https://doi.org/10.1016/S1474-4422(17)30378-2

Article  PubMed  Google Scholar 

Armstrong RA (2014) When to use the Bonferroni correction. Ophthalmic Physiol Opt 34(5):502–508. https://doi.org/10.1111/opo.12131

Article  PubMed  Google Scholar 

Launay M, Delmont E, Benaim C, Sacconi S, Butori C, Desnuelle C (2009) Les polyneuropathies avec IgM monoclonale anti-MAG : étude descriptive clinique, biologique, électrophysiologique et anatomopathologique d’une cohorte de 13 patients [Anti-MAG paraproteinemic demyelinating polyneuropathy: a clinical, biological, electrophysiological and anatomopathological descriptive study of a 13-patients’ cohort]. Rev Neurol (Paris) 165(12):1071–1079. https://doi.org/10.1016/j.neurol.2009.04.008. (French)

Article  CAS  PubMed  Google Scholar 

Chassande B, Léger JM, Younes-Chennouf AB, Bengoufa D, Maisonobe T, Bouche P et al (1998) Peripheral neuropathy associated with IgM monoclonal gammopathy: correlations between M-protein antibody activity and clinical/electrophysiological features in 40 cases. Muscle Nerve 21:55–62

Article  CAS  PubMed  Google Scholar 

Tang MH, Mathis S, Duffau P, Cazenave P, Solé G, Duval F, Soulages A, Le Masson G (2020) Prognostic factor of poor outcome in anti-MAG neuropathy: clinical and electrophysiological analysis of a French Cohort. J Neurol 267(2):561–571. https://doi.org/10.1007/s00415-019-09618-0

Article  CAS  PubMed  Google Scholar 

Xu L, Hunter ZR, Yang G, Cao Y, Liu X, Manning R, Tripsas C, Chen J, Patterson CJ, Kluk M, Kanan S, Castillo J, Lindeman N, Treon SP (2014) Detection of MYD88 L265P in peripheral blood of patients with Waldenström’s Macroglobulinemia and IgM monoclonal gammopathy of undetermined significance. Leukemia 28(8):1698–1704. https://doi.org/10.1038/leu.2014.65

Article  CAS  PubMed  Google Scholar 

Castellani F, Visentin A, Schirinzi E, Salvalaggio A, Cacciavillani M, Candiotto C, Baratè C, Cellini A, Bertorelle R, Siciliano G, Trentin L, Briani C (2023) Mutational profile in 75 patients with anti-myelin-associated glycoprotein neuropathy: clinical and hematologic therapy response and hints on new therapeutic targets. Neurol Neuroimmunol Neuroinflamm 10(4):e200122. https://doi.org/10.1212/NXI.0000000000200122

Article  PubMed  PubMed Central  Google Scholar 

Vinarkar S, Arora N, Chowdhury SS, Saha K, Pal B, Parihar M, Radhakrishnan VS, Chakrapani A, Bhartia S, Bhave S, Chandy M, Nair R, Mishra DK (2019) MYD88 and CXCR4 mutation profiling in lymphoplasmacytic lymphoma/Waldenstrom’s Macroglobulinaemia. Indian J Hematol Blood Transfus 35(1):57–65. https://doi.org/10.1007/s12288-018-0978-1

Article  PubMed 

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