The diagnostic role of arginine-stimulated copeptin in the differential diagnosis of polyuria-polydipsia syndrome (PPS) in pediatric age

E. Dabrowski, R. Kadakia, D. Zimmerman, R.H. Lurie, Diabetes insipidus in infants and children. Best. Pract. Res Clin. Endocrinol. Metab. 30, 317–328 (2016)

Article  PubMed  Google Scholar 

N. Di Iorgi, F. Napoli, A.E.M. Allegri, Diabetes insipidus–diagnosis and management. Horm. Res Paediatr. 77, 69–84 (2012)

Article  PubMed  Google Scholar 

N. Di Iorgi, G. Morana, F. Napoli, A.E.M. Allegri, A. Rossi, M. Maghnie, Management of diabetes insipidus and adipsia in the child. Best. Pract. Res Clin. Endocrinol. Metab. 29, 415–436 (2015)

Article  PubMed  Google Scholar 

W. Fenske, M. Quinkler, D. Lorenz, K. Zopf, U. Haagen, J. Papassotiriou et al. Copeptin in the differential diagnosis of the polydipsia-polyuria syndrome—revisiting the direct and indirect water deprivation tests. J. Clin. Endocrinol. Metab. 5, 1506–1515 (2011)

Article  Google Scholar 

W. Fenske, J. Refardt, I. Chifu, I. Schnyder, B. Winzeler, J. Drummond et al. A Copeptin-based approach in the diagnosis of diabetes insipidus. N. Engl. J. Med. 379, 428–439 (2018)

Article  CAS  PubMed  Google Scholar 

N. Nigro, B. Muller, N.G. Morgenthaler, F. Fluri, P. Schutz, S. Neidert et al. The use of copeptin, the stable peptide of the vasopressin precursor, in the differential diagnosis of sodium imbalance in patients with acute diseases. Swiss Med. Wkly 141, 1–11 (2011)

Google Scholar 

S. Balanescu, P. Kopp, M.B. Gaskill, N.G. Morgenthaler, C. Schindler, J. Ratishauer, Correlation of plasma copeptin and vasopressin concentrations in hypo-, iso-and hypermolar states. J. Clin. Endocrinol. Metab. 96, 1046–1052 (2011)

Article  CAS  PubMed  Google Scholar 

W. Fenske, B. Allolio, Current state and future perspectives in the diagnosis of diabetes insipidus: a clinical review. J. Clin. Endocrinol. Metab. 10, 3426–3437 (2012)

Article  Google Scholar 

K. Timper, W. Fenske, F. Kuhn, N. Frech, B. Arici, J. Ratishauser et al. Diagnostic accuracy of copeptin in the differential diagnosis of the polyuria-polydipsia syndrome: a prospective multicenter study. J. Clin. Endocrinol. Metab. 6, 2268–2274 (2015)

Article  Google Scholar 

B. Winzeler, C. Zweifel, N. Nigro, B. Arici, M. Bally, P. Schutz et al. Postoperative copeptin concentration predicts diabetes insipidus after pituitary surgery. J. Clin. Endocrinol. Metab. 6, 2275–2282 (2015)

Article  Google Scholar 

M. de Fost, S.M. Oussada, G.E. Linthorst, M.J. Serlie, M.R. Soeters, J.H. De Vries et al. The water deprivation test and a potential role for the arginine vasopressin precursor copeptin to differentiate diabetes insipidus from primary polydipsia. Endocr. Conn. 4, 86–91 (2015).

Article  Google Scholar 

M. Christ-Crain, W. Fenske, Copeptin in the diagnosis of vasopressin dependent disorders of fluid homeostasis. Nat. Rev. Endocr. 12, 168–176 (2016)

Article  CAS  Google Scholar 

G. Tuli, D. Tessaris, S. Einaudi, P. Matarazzo, L. De Sanctis, Copeptin role in polyuria-polydipsia syndrome differential diagnosis and reference range in paediatric age. Clin. Endocrinol. (Oxf.) 88, 873–879 (2018)

Article  CAS  PubMed  Google Scholar 

L. Bonnet, E. Marquant, J. Fromonot, I. Hamouda, J. Berbis, A. Godefroy et al. Copeptin assays in children for the differential diagnosis of polyuria-polydipsia syndrome and reference levels in hospitalized children. Clin. Endocrinol. (Oxf.) 96, 47–53 (2021)

Article  PubMed  Google Scholar 

B. Winzeler, N. Cesana-Nigro, J. Refardt, D.R. Vogt, C. Imber, B. Morin et al. Arginine-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a prospective diagnostic study. Lancet 394, 587–595 (2019)

Article  CAS  PubMed  Google Scholar 

J. Refardt, C. Atila, I. Chifu, E. Ferrante, Z. Erlic, J.B. Drummond et al. Arginine or hypertonic saline-stimulated copeptin to diagnose AVP deficiency. N. Engl. J. Med. 389, 1877–1887 (2023)

Article  CAS  PubMed  Google Scholar 

G. Binder, K. Weber, A. Peter, R. Schweizer, Arginine-stimulated copeptin in children and adolescents. Clin. Endocrinol. (Oxf.) 98, 548–553 (2023)

Article  CAS  PubMed  Google Scholar 

Comments (0)

No login
gif