Regulation and targeting of SREBP-1 in hepatocellular carcinoma

European Association For The Study Of The Liver. (2018). EASL clinical practice guidelines: Management of hepatocellular carcinoma. Journal of Hepatology, 69(1), 182–236. https://doi.org/10.1016/j.jhep.2018.03.019

Article  Google Scholar 

Vogel, A., Meyer, T., Sapisochin, G., Salem, R., & Saborowski, A. (2022). Hepatocellular carcinoma. The Lancet, 400(10360), 1345–1362. https://doi.org/10.1016/S0140-6736(22)01200-4

Article  CAS  Google Scholar 

Tilg, H., Adolph, T. E., Dudek, M., & Knolle, P. (2021). Non-alcoholic fatty liver disease: The interplay between metabolism, microbes and immunity. Nature Metabolism, 3(12), 1596–1607. https://doi.org/10.1038/s42255-021-00501-9

Article  CAS  PubMed  Google Scholar 

Muir, K., Hazim, A., He, Y., Peyressatre, M., Kim, D. Y., Song, X., & Beretta, L. (2013). Proteomic and lipidomic signatures of lipid metabolism in NASH-associated hepatocellular carcinoma. Cancer Research, 73(15), 4722–4731. https://doi.org/10.1158/0008-5472.CAN-12-3797

Article  CAS  PubMed  Google Scholar 

Wang, M., Han, J., Xing, H., Zhang, H., Li, Z., Liang, L., Li, C., Dai, S., Wu, M., Shen, F., & Yang, T. (2016). Dysregulated fatty acid metabolism in hepatocellular carcinoma. Hepatic Oncology, 3(4), 241–251. https://doi.org/10.2217/hep-2016-0012

Article  PubMed  Google Scholar 

Calvisi, D. F., Wang, C., Ho, C., Ladu, S., Lee, S. A., Mattu, S., Destefanis, G., Delogu, S., Zimmermann, A., Ericsson, J., Brozzetti, S., Staniscia, T., Chen, X., Dombrowski, F., & Evert, M. (2011). Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Gastroenterology, 140(3), 1071–1083. https://doi.org/10.1053/j.gastro.2010.12.006

Article  CAS  PubMed  Google Scholar 

Snaebjornsson, M. T., Janaki-Raman, S., & Schulze, A. (2020). Greasing the wheels of the cancer machine: The role of lipid metabolism in cancer. Cell Metabolism, 31(1), 62–76. https://doi.org/10.1016/j.cmet.2019.11.010

Article  CAS  PubMed  Google Scholar 

Li, T., Weng, J., Zhang, Y., Liang, K., Fu, G., Li, Y., Bai, X., & Gao, Y. (2019). mTOR direct crosstalk with STAT5 promotes de novo lipid synthesis and induces hepatocellular carcinoma. Cell Death & Disease, 10(8), 619. https://doi.org/10.1038/s41419-019-1828-2

Article  CAS  Google Scholar 

Li, C., Yang, W., Zhang, J., Zheng, X., Yao, Y., Tu, K., & Liu, Q. (2014). SREBP-1 has a prognostic role and contributes to invasion and metastasis in human hepatocellular carcinoma. International Journal of Molecular Sciences, 15(5), 7124–7138. https://doi.org/10.3390/ijms15057124

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shimano, H. (2001). Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Progress in Lipid Research, 40(6), 439–452. https://doi.org/10.1016/S0163-7827(01)00010-8

Article  CAS  PubMed  Google Scholar 

Jeon, Y. G., Kim, Y. Y., Lee, G., & Kim, J. B. (2023). Physiological and pathological roles of lipogenesis. Nature Metabolism, 5(5), 735–759. https://doi.org/10.1038/s42255-023-00786-y

Article  CAS  PubMed  Google Scholar 

Soyal, S. M., Nofziger, C., Dossena, S., Paulmichl, M., & Patsch, W. (2015). Targeting SREBPs for treatment of the metabolic syndrome. Trends in Pharmacological Sciences, 36(6), 406–416. https://doi.org/10.1016/j.tips.2015.04.010

Article  CAS  PubMed  Google Scholar 

Zhao, Q., Lin, X., & Wang, G. (2022). Targeting SREBP-1-mediated lipogenesis as potential strategies for cancer. Frontiers in Oncology, 12, 952371. https://doi.org/10.3389/fonc.2022.952371

Article  CAS  PubMed  PubMed Central  Google Scholar 

Athanikar, J. N., & Osborne, T. F. (1998). Specificity in cholesterol regulation of gene expression by coevolution of sterol regulatory DNA element and its binding protein. Proceedings of the National Academy of Sciences of the United States of America, 95(9), 4935–4940. https://doi.org/10.1073/pnas.95.9.4935

Article  CAS  PubMed  PubMed Central  Google Scholar 

Amemiya-Kudo, M., Shimano, H., Yoshikawa, T., Yahagi, N., Hasty, A. H., Okazaki, H., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., Osuga, J., Harada, K., Gotoda, T., Sato, R., Kimura, S., Ishibashi, S., & Yamada, N. (2000). Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene. Journal of Biological Chemistry, 275(40), 31078–31085. https://doi.org/10.1074/jbc.M005353200

Article  CAS  PubMed  Google Scholar 

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002). SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. The Journal of Clinical Investigation, 109(9), 1125–1131. https://doi.org/10.1172/JCI15593

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shimano, H., Horton, J. D., Shimomura, I., Hammer, R. E., Brown, M. S., & Goldstein, J. L. (1997). Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. The Journal of Clinical Investigation, 99(5), 846–854. https://doi.org/10.1172/JCI119248

Article  CAS  PubMed  PubMed Central  Google Scholar 

Foretz, M., Guichard, C., Ferre, P., & Foufelle, F. (1999). Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proceedings of the National Academy of Sciences of the United States of America, 96(22), 12737–12742. https://doi.org/10.1073/pnas.96.22.12737

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shechter, I., Dai, P., Huo, L., & Guan, G. (2003). IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: Evidence that IDH1 may regulate lipogenesis in hepatic cells. Journal of Lipid Research, 44(11), 2169–2180. https://doi.org/10.1194/jlr.M300285-JLR200

Article  CAS  PubMed  Google Scholar 

Lee, J. N., Song, B., DeBose-Boyd, R. A., & Ye, J. (2006). Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78. Journal of Biological Chemistry, 281(51), 39308–39315. https://doi.org/10.1074/jbc.M608999200

Article  CAS  PubMed  Google Scholar 

Liu, T. F., Tang, J. J., Li, P. S., Shen, Y., Li, J. G., Miao, H. H., Li, B. L., & Song, B. L. (2012). Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis. Cell Metabolism, 16(2), 213–225. https://doi.org/10.1016/j.cmet.2012.06.014

Article  CAS  PubMed  Google Scholar 

Wang, X., Sato, R., Brown, M. S., Hua, X., & Goldstein, J. L. (1994). SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell, 77(1), 53–62. https://doi.org/10.1016/0092-8674(94)90234-8

Article  CAS  PubMed  Google Scholar 

Radhakrishnan, A., Ikeda, Y., Kwon, H. J., Brown, M. S., & Goldstein, J. L. (2007). Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig. Proceedings of the National Academy of Sciences of the United States of America, 104(16), 6511–6518. https://doi.org/10.1073/pnas.0700899104

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adams, C. M., Reitz, J., De Brabander, J. K., Feramisco, J. D., Li, L., Brown, M. S., & Goldstein, J. L. (2004). Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. The Journal of Biological Chemistry, 279(50), 52772–52780. https://doi.org/10.1074/jbc.M410302200

Article  CAS  PubMed  Google Scholar 

Moon, Y. A., Hammer, R. E., & Horton, J. D. (2009). Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice. Journal of Lipid Research, 50(3), 412–423. https://doi.org/10.1194/jlr.M800383-JLR200

Article  CAS  PubMed  PubMed Central  Google Scholar 

Williams, K. J., Argus, J. P., Zhu, Y., Wilks, M. Q., Marbois, B. N., York, A. G., Kidani, Y., Pourzia, A. L., Akhavan, D., Lisiero, D. N., Komisopoulou, E., Henkin, A. H., Soto, H., Chamberlain, B. T., Vergnes, L., Jung, M. E., Torres, J. Z., Liau, L. M., Christofk, H. R., et al. (2013). An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. Cancer Research, 73(9), 2850–2862. https://doi.org/10.1158/0008-5472.CAN-13-0382-T

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang, D., Minikes, A. M., & Jiang, X. (2022). Ferroptosis at the intersection of lipid metabolism and cellular signaling. Molecular Cell, 82(12), 2215–2227. https://doi.org/10.1016/j.molcel.2022.03.022

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, M., Wei, T., Zhang, X., & Guo, D. (2022). Targeting lipid metabolism reprogramming of immunocytes in response to the tumor microenvironment stressor: A potential approach for tumor therapy. Frontiers in Immunology, 13, 937406. https://doi.org/10.3389/fimmu.2022.937406

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park, H. Y., Kang, H. S., & Im, S. S. (2018). Recent insight into the correlation of SREBP-mediated lipid metabolism and innate immune response. The Journal of Molecular Endocrinology, 61(3), R123–r131. https://doi.org/10.1530/jme-17-0289

Article  CAS  PubMed  Google Scholar 

Dyall, S. C., Balas, L., Bazan, N. G., Brenna, J. T., Chiang, N., da Costa Souza, F., Dalli, J., Durand, T., Galano, J. M., Lein, P. J., Serhan, C. N., & Taha, A. Y. (2022). Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions. Progress in Lipid Research, 86, 101165. https://doi.org/10.1016/j.plipres.2022.101165

Article  CAS  PubMed  PubMed Central 

Comments (0)

No login
gif