Medium- and long-chain triglyceride propofol activates PI3K/AKT pathway and inhibits non-alcoholic fatty liver disease by inhibiting lipid accumulation

Alves-Bezerra M, Cohen DE (2017) Triglyceride metabolism in the liver. Compr Physiol 8:1–8. https://doi.org/10.1002/cphy.c170012

Article  PubMed  PubMed Central  Google Scholar 

Chen Z, Chen L, Sun B et al (2021) LDLR inhibition promotes hepatocellular carcinoma proliferation and Metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway. Mol Metabolism (Germany) 51:101230. https://doi.org/10.1016/j.molmet.2021.101230

Article  CAS  Google Scholar 

Deprince A, Haas JT, Staels B (2020) Dysregulated lipid metabolism links NAFLD to Cardiovascular Disease. Mol Metab 42:101092. https://doi.org/10.1016/j.molmet.2020.101092

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dostert C, Grusdat M, Letellier E et al (2019) The TNF family of ligands and receptors: communication modules in the Immune System and Beyond. Physiol Rev 99:115–160. https://doi.org/10.1152/physrev.00045.2017

Article  CAS  PubMed  Google Scholar 

Fan Y, He Z, Wang W et al (2018) Tangganjian decoction ameliorates type 2 Diabetes Mellitus and nonalcoholic fatty Liver Disease in rats by activating the IRS/PI3K/AKT signaling pathway. Biomed Pharmacother 106:733–737. https://doi.org/10.1016/j.biopha.2018.06.089

Article  PubMed  Google Scholar 

Feng X, Yu W, Li X et al (2017) Apigenin, a modulator of PPARgamma, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. Biochem Pharmacol 136:136–149. https://doi.org/10.1016/j.bcp.2017.04.014

Article  CAS  PubMed  Google Scholar 

Friedman SL, Neuschwander-Tetri BA, Rinella M et al (2018) Mechanisms of NAFLD development and therapeutic strategies. Nat Med 24:908–922. https://doi.org/10.1038/s41591-018-0104-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao H, Zhong Y, Zhou L et al (2023) Kindlin-2 inhibits TNF/NF-kappaB-caspase 8 pathway in hepatocytes to maintain liver development and function. Elife 12. https://doi.org/10.7554/eLife.81792

He T, Zhao Y, Zhao P et al (2022) Signaling pathway(s) of TNFR2 required for the immunoregulatory effect of CD4(+)Foxp3(+) regulatory T cells. Int Immunopharmacol 108:108823. https://doi.org/10.1016/j.intimp.2022.108823

Article  CAS  PubMed  Google Scholar 

Li M, Ye J, Zhao G et al (2019) Gas6 attenuates lipopolysaccharideinduced TNFalpha expression and apoptosis in H9C2 cells through NFkappaB and MAPK inhibition via the Axl/PI3K/Akt pathway. Int J Mol Med 44:982–994. https://doi.org/10.3892/ijmm.2019.4275

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Wang T, Liu P et al (2021) Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD. Food Funct 12:3898–3918. https://doi.org/10.1039/d0fo02736g

Article  CAS  PubMed  Google Scholar 

Liang J, Liu Y, Liu J et al (2018) Chitosan-functionalized lipid-polymer hybrid nanoparticles for oral delivery of silymarin and enhanced lipid-lowering effect in NAFLD. J Nanobiotechnol 16:64. https://doi.org/10.1186/s12951-018-0391-9

Article  CAS  Google Scholar 

Lien EC, Dibble CC, Toker A (2017) PI3K signaling in cancer: beyond AKT. Curr Opin Cell Biol 45:62–71. https://doi.org/10.1016/j.ceb.2017.02.007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Powell EE, Wong VW, Rinella M (2021) Non-alcoholic fatty Liver Disease. Lancet 397:2212–2224. https://doi.org/10.1016/S0140-6736(20)32511-3

Article  CAS  PubMed  Google Scholar 

Singla B, Malde AD (2018) A prospective observational study of injection pain in children with medium plus long chain triglyceride and long chain triglyceride propofol premixed with lignocaine. Indian J Anaesth 62:214–218. https://doi.org/10.4103/ija.IJA_506_17

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tan X, Cao Z, Li M et al (2016) TNF-alpha downregulates CIDEC via MEK/ERK pathway in human adipocytes. Obes (Silver Spring) 24:1070–1080. https://doi.org/10.1002/oby.21436

Article  CAS  Google Scholar 

Walsh CT (2018) Propofol: milk of Amnesia. Cell 175:10–13. https://doi.org/10.1016/j.cell.2018.08.031

Article  CAS  PubMed  Google Scholar 

Wang LY, Wu J, Gao YF et al (2020a) Medium- and long-chain triglyceride propofol reduces the activity of acetyl-coenzyme A carboxylase in hepatic lipid metabolism in HepG2 and Huh7 cells. Korean J Physiol Pharmacol 24:19–26. https://doi.org/10.4196/kjpp.2020.24.1.19

Article  CAS  PubMed  Google Scholar 

White MF (1997) The insulin signalling system and the IRS proteins. Diabetologia 40 Suppl 2S2–S17. https://doi.org/10.1007/s001250051387

Wisessaowapak C, Watcharasit P, Satayavivad J (2021) Arsenic disrupts neuronal insulin signaling through increasing free PI3K-p85 and decreasing PI3K activity. Toxicol Lett 349:40–50. https://doi.org/10.1016/j.toxlet.2021.06.002

Article  CAS  PubMed  Google Scholar 

Wittka A, Ketteler J, Borgards L et al (2022) Stromal fibroblasts counteract the Caveolin-1-Dependent Radiation response of LNCaP prostate carcinoma cells. Front Oncol 12:802482. https://doi.org/10.3389/fonc.2022.802482

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu HM, Ni XX, Xu QY et al (2020) Regulation of lipid-induced macrophage polarization through modulating PPAR‐γ activity affects hepatic lipid metabolism via TLR4/NF‐κB signaling pathway. J Gastroenterol Hepatol. https://doi.org/10.1111/jgh.15025

Article  PubMed  PubMed Central  Google Scholar 

Wu SC, Lo YM, Lee JH et al (2022) Stomatin modulates adipogenesis through the ERK pathway and regulates fatty acid uptake and lipid droplet growth. Nat Commun 13:4174. https://doi.org/10.1038/s41467-022-31825-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang J, Fernandez-Galilea M, Martinez-Fernandez L et al (2019) Oxidative stress and non-alcoholic fatty Liver Disease: effects of Omega-3 fatty acid supplementation. Nutrients 11. https://doi.org/10.3390/nu11040872

Yew WS, Chong SY, Tan KH et al (2005) The effects of Intravenous Lidocaine on Pain during injection of medium- and long-chain triglyceride propofol emulsions. Anesth Analg 100:1693–1695. https://doi.org/10.1213/01.ANE.0000151718.58709.0B

Article  CAS  PubMed  Google Scholar 

Zhang Z, Tian L, Jiang K (2019) Propofol attenuates inflammatory response and apoptosis to protect d-galactosamine/lipopolysaccharide induced acute liver injury via regulating TLR4/NF-κB/NLRP3 pathway. Int Immunopharmacol 77:105974. https://doi.org/10.1016/j.intimp.2019.105974

Article  CAS  PubMed  Google Scholar 

Zhang N, Wang Y, Zhang J et al (2020) N-glycosylation of CREBH improves lipid metabolism and attenuates lipotoxicity in NAFLD by modulating PPARα and SCD‐1. FASEB J 34:15338–15363. https://doi.org/10.1096/fj.202000836RR

Article  CAS  PubMed  Google Scholar 

Zhao XJ, Yu HW, Yang YZ et al (2018) Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway. Redox Biol 18:124–137. https://doi.org/10.1016/j.redox.2018.07.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou J, Zhou F, Wang W et al (2020) Epidemiological features of NAFLD from 1999 to 2018 in China. Hepatology 71:1851–1864. https://doi.org/10.1002/hep.31150

Article  PubMed  Google Scholar 

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