Afghani E, Klein AP (2022) Pancreatic Adenocarcinoma: Trends in Epidemiology, Risk Factors, and Outcomes. Hematol Oncol Clin North Am 36(5):879–895. https://doi.org/10.1016/j.hoc.2022.07.002
Article PubMed PubMed Central Google Scholar
Anwar S, Shamsi A, Mohammad T, Islam A, Hassan MI (2021) Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy. Biochim Biophys Acta Rev Cancer 1876(1):188568. https://doi.org/10.1016/j.bbcan.2021.188568
Article PubMed CAS Google Scholar
Atas E, Oberhuber M, Kenner L (2020) The Implications of PDK1-4 on Tumor Energy Metabolism. Aggressiveness Ther Resist Front Oncol 10:583217. https://doi.org/10.3389/fonc.2020.583217
Cao W, Zeng Z, Pan R, Wu H, Zhang X, Chen H, Nie Y, Yu Z, Lei S (2021) Hypoxia-Related Gene FUT11 Promotes Pancreatic Cancer Progression by Maintaining the Stability of PDK1. Front Oncol 11:675991. https://doi.org/10.3389/fonc.2021.675991
Article PubMed PubMed Central CAS Google Scholar
Carbone D, De Franco M, Pecoraro C, Bassani D, Pavan M, Cascioferro S, Parrino B, Cirrincione G, Dall’Acqua S, Moro S, Gandin V, Diana P (2023) Discovery of the 3-Amino-1,2,4-triazine-Based Library as Selective PDK1 Inhibitors with Therapeutic Potential in Highly Aggressive Pancreatic Ductal Adenocarcinoma. Int J Mol Sci 24(4):3679. https://doi.org/10.3390/ijms24043679
Article PubMed PubMed Central CAS Google Scholar
Chen W, Xu J, Wu Y, Liang B, Yan M, Sun C, Wang D, Hu X, Liu L, Hu W, Shao Y, Xing D (2023a) The potential role and mechanism of circRNA/miRNA axis in cholesterol synthesis. Int J Biol Sci 19(9):2879–2896. https://doi.org/10.7150/ijbs.84994
Article PubMed PubMed Central CAS Google Scholar
Chen Y, Wang F, Li J, Wang W, Ge L, Ge L (2023b) Long non-coding RNA TCL6 induced by SCRT1 promotes proliferation and metastasis of non-small cell lung cancer through PDK1/AKT signaling. Pathol Res Pract 246:154491. https://doi.org/10.1016/j.prp.2023.154491
Article PubMed CAS Google Scholar
Du Y, Zhu J, Chu BF, Yang YP, Zhang SL (2019) MiR-548c-3p suppressed the progression of papillary thyroid carcinoma via inhibition of the HIF1α-mediated VEGF signaling pathway. Eur Rev Med Pharmacol Sci. 23(15):6570–6578. https://doi.org/10.26355/eurrev_201908_18543
Article PubMed CAS Google Scholar
Ghazimoradi MH, Babashah S (2022) The role of CircRNA/miRNA/mRNA axis in breast cancer drug resistance. Front Oncol 12:966083. https://doi.org/10.3389/fonc.2022.966083
Article PubMed PubMed Central CAS Google Scholar
Gu A, Jaijyan DK, Yang S, Zeng M, Pei S, Zhu H (2023) Functions of Circular RNA in Human Diseases and Illnesses. Noncoding RNA 9(4):38. https://doi.org/10.3390/ncrna9040038
Article PubMed PubMed Central CAS Google Scholar
Guan H, Luo W, Liu Y, Li M (2021) Novel circular RNA circSLIT2 facilitates the aerobic glycolysis of pancreatic ductal adenocarcinoma via miR-510-5p/c-Myc/LDHA axis. Cell Death Dis 12(7):645. https://doi.org/10.1038/s41419-021-03918-y
Article PubMed PubMed Central CAS Google Scholar
Guz M, Jeleniewicz W, Cybulski M (2023) Interactions between circRNAs and miR-141 in Cancer: From Pathogenesis to Diagnosis and Therapy. Int J Mol Sci 24(14):11861. https://doi.org/10.3390/ijms241411861
Article PubMed PubMed Central CAS Google Scholar
Jaworska M, Szczudło J, Pietrzyk A, Shah J, Trojan SE, Ostrowska B, Kocemba-Pilarczyk KA (2023) The Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells. Pharmacol Rep 75(4):876–890. https://doi.org/10.1007/s43440-023-00504-1
Article PubMed PubMed Central CAS Google Scholar
Kim WR, Park EG, Lee DH, Lee YJ, Bae WH, Kim HS (2023) The Tumorigenic Role of Circular RNA-MicroRNA Axis in Cancer. Int J Mol Sci 24(3):3050. https://doi.org/10.3390/ijms24033050
Article PubMed PubMed Central CAS Google Scholar
Li B, Liang L, Chen Y, Liu J, Wang Z, Mao Y, Zhao K, Chen J (2022a) Circ_0008287 promotes immune escape of gastric cancer cells through impairing microRNA-548c-3p-dependent inhibition of CLIC1. Int Immunopharmacol 111:108918. https://doi.org/10.1016/j.intimp.2022.108918
Article PubMed CAS Google Scholar
Li J, Xu Q, Huang ZJ, Mao N, Lin ZT, Cheng L, Sun B, Wang G (2021) CircRNAs: a new target for the diagnosis and treatment of digestive system neoplasms. Cell Death Dis 12(2):205. https://doi.org/10.1038/s41419-021-03495-0
Article PubMed PubMed Central CAS Google Scholar
Li J, Ye Z, Hu X, Hou S, Hang Q (2022b) Prognostic, Diagnostic, and Clinicopathological Significance of Circular RNAs in Pancreatic Cancer: A Systematic Review and Meta-Analysis. Cancers 14(24):6187. https://doi.org/10.3390/cancers14246187
Article PubMed PubMed Central CAS Google Scholar
Lin J, Wang X, Zhai S, Shi M, Peng C, Deng X, Fu D, Wang J, Shen B (2022) Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1. J Hematol Oncol 15(1):128. https://doi.org/10.1186/s13045-022-01348-7
Article PubMed PubMed Central CAS Google Scholar
Liu A, Xu J (2021) Circ_03955 promotes pancreatic cancer tumorigenesis and Warburg effect by targeting the miR-3662/HIF-1α axis. Clin Transl Oncol 23(9):1905–1914. https://doi.org/10.1007/s12094-021-02599-5
Article PubMed CAS Google Scholar
Liu B, Gong Y, Jiang Q, Wu S, Han B, Chen F, Lin Q, Wang P, Yang D (2023a) Hsa_circ_0014784-induced YAP1 promoted the progression of pancreatic cancer by sponging miR-214-3p. Cell Cycle 22(13):1583–1596. https://doi.org/10.1080/15384101.2023.2222519
Article PubMed PubMed Central CAS Google Scholar
Liu Z, Hayashi H, Matsumura K, Uemura N, Shiraishi Y, Sato H, Baba H (2023b) Biological and Clinical Impacts of Glucose Metabolism in Pancreatic Ductal Adenocarcinoma. Cancers (basel) 15(2):498. https://doi.org/10.3390/cancers15020498
Article PubMed CAS Google Scholar
Ma Y, Zhang X, Han X, Hao Z, Ji R, Li J, Guo W, Zhang Y, Guan F, Ma S (2023) PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming. Mol Carcinog 62(6):866–881. https://doi.org/10.1002/mc.23531
Article PubMed CAS Google Scholar
Malviya A, Bhuyan R (2023) The recent advancements in circRNA research: From biogenesis to therapeutic interventions. Pathol Res Pract 248:154697. https://doi.org/10.1016/j.prp.2023.154697
Article PubMed CAS Google Scholar
Meng H, Niu R, Huang C, Li J (2022) Circular RNA as a Novel Biomarker and Therapeutic Target for HCC. Cells 11(12):1948. https://doi.org/10.3390/cells11121948
Article PubMed PubMed Central CAS Google Scholar
Miao S, Zhang Q (2023) Circulating circRNA: a social butterfly in tumors. Front Oncol 13:1203696. https://doi.org/10.3389/fonc.2023.1203696
Article PubMed PubMed Central CAS Google Scholar
Montalvo-Javé EE, Nuño-Lámbarri N, López-Sánchez GN, Ayala-Moreno EA, Gutierrez-Reyes G, Beane J (2023) Pawlik TM (2023) Pancreatic Cancer: Genetic Conditions and Epigenetic Alterations. J Gastrointest Surg 27(5):1001–1010. https://doi.org/10.1007/s11605-022-05553-0
Rao G, Peng X, Tian Y, Fu X, Zhang Y (2023) Circular RNAs in hepatocellular carcinoma: biogenesis, function, and pathology. Front Genet 14:1106665. https://doi.org/10.3389/fgene.2023.1106665
Article PubMed PubMed Central CAS Google Scholar
Saxton RA, Sabatini DM (2017) mTOR Signaling in Growth, Metabolism, and Disease. Cell 168(6):960–976. https://doi.org/10.1016/j.cell.2017.02.004
Article PubMed PubMed Central CAS Google Scholar
Sayad A, Najafi S, Hussen BM, Jamali E, Taheri M, Ghafouri-Fard S (2022) The role of circular RNAs in pancreatic cancer: new players in tumorigenesis and potential biomarkers. Pathol Res Pract 232:153833. https://doi.org/10.1016/j.prp.2022.153833
Article PubMed CAS Google Scholar
Sempere LF, Powell K, Rana J, Brock AA, Schmittgen TD (2021) Role of non-coding RNAs in tumor progression and metastasis in pancreatic cancer. Cancer Metastasis Rev 40(3):761–776. https://doi.org/10.1007/s10555-021-09995-x
Article PubMed PubMed Central CAS Google Scholar
Su T, Liu J, Zhang N, Wang T, Han L, Wang S, Yang M (2023) New insights on the interplays between m6A modifications and microRNA or lncRNA in gastrointestinal cancers. Front Cell Dev Biol 11:1157797. https://doi.org/10.3389/fcell.2023.1157797
Comments (0)