Natural Sirtuin1 Activators and Atherosclerosis: an Overview

WHO. Noncommunicable diseases. 2022. https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases

Björkegren JLM, Lusis AJ. Atherosclerosis: recent developments. Cell. 2022;185:1630–45 (Elsevier B.V).

Article  PubMed  PubMed Central  Google Scholar 

Yang Y, Liu Y, Wang Y, Chao Y, Zhang J, Jia Y, Tie J, Hu D. Regulation of SIRT1 and its roles in inflammation. Front Immunol. 2022;13:1–16. https://doi.org/10.3389/fimmu.2022.831168.

Article  CAS  Google Scholar 

Rinninella E, Cintoni M, Raoul P, Lopetuso LR, Scaldaferri F, Pulcini G, Miggiano GAD, Gasbarrini A, Mele MC. Food components and dietary habits: keys for a healthy gut microbiota composition. Nutrients. 2019;11(10):2393. https://doi.org/10.3390/nu11102393.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cena H, Calder PC. Defining a healthy diet: evidence for the role of contemporary dietary patterns in health and disease. Nutrients. 2020;12(2):334. https://doi.org/10.3390/nu12020334.

Minelli P, Montinari MR. The Mediterranean diet and cardioprotection: historical overview and current research. J Multidiscip Healthc. 2019;12:805–15. https://doi.org/10.2147/JMDH.S219875.

Article  PubMed  PubMed Central  Google Scholar 

Santhakumar AB, Battino M, Alvarez-Suarez JM. Dietary polyphenols: structures, bioavailability and protective effects against atherosclerosis. Food Chem Toxicol. 2018;113. https://doi.org/10.1016/j.fct.2018.01.022.

Riccardi G, Giosuè A, Calabrese I, Vaccaro O. Dietary recommendations for prevention of atherosclerosis. Cardiovasc Res. 2022;118(5):1188–204. https://doi.org/10.1093/cvr/cvab173.

Article  CAS  PubMed  Google Scholar 

Teodoro AJ. Bioactive compounds of food: their role in the prevention and treatment of diseases. Oxidative Med Cell Longev. 2019;2019:3765986. https://doi.org/10.1155/2019/3765986.

Article  CAS  Google Scholar 

Kang H, Kim B. Bioactive compounds as inhibitors of inflammation, oxidative stress and metabolic dysfunctions via regulation of cellular redox balance and histone acetylation state. Foods. 2023;12(5):925. https://doi.org/10.3390/foods12050925.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rudrapal M, Khairnar SJ, Khan J, Dukhyil AB, Ansari MA, Alomary MN, Alshabrmi FM, Palai S, Deb PK, Devi R. Dietary polyphenols and their role in oxidative stress-induced human diseases: insights into protective effects, antioxidant potentials and mechanism(s) of action. Front Pharmacol. 2022;13:806470. https://doi.org/10.3389/fphar.2022.806470.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vlčko T, Rathod NB, Kulawik P, Ozogul Y, Ozogul F. The impact of aromatic plant-derived bioactive compounds on seafood quality and safety. Adv Food Nutr Res. 2022;1(102):275–339.

Article  Google Scholar 

Tang H, Li K, Zhang S, Lan H, Liang L, Huang C, et al. Inhibitory effect of paeonol on apoptosis, oxidative stress, and inflammatory response in human umbilical vein endothelial cells induced by high glucose and palmitic acid induced through regulating SIRT1/FOXO3a/NF-κB pathway. J Interferon Cytokine Res. 2021;41(3):111–24.

Article  CAS  PubMed  Google Scholar 

KP AD, Shimoga Janakirama AR, Martin A. SIRT1 activation by taurine: in vitro evaluation, molecular docking and molecular dynamics simulation studies. J Nutr Biochem. 2022;102. https://doi.org/10.1016/j.jnutbio.2022.108948.

Xiong Y, Wang HX, Yan H, Zhu SL, Guo SW, Peng WJ, et al. Rutaecarpine prevents high glucose-induced endothelial cell senescence through transient receptor potential vanilloid subtype 1/ SIRT1 pathway. J Cardiovasc Pharmacol. 2022;79(1):e129–37.

Article  CAS  PubMed  Google Scholar 

Du C, Lin X, Xu W, Zheng F, Cai J, Yang J, et al. Sulfhydrated sirtuin-1 increasing its deacetylation activity is an essential epigenetics mechanism of anti-atherogenesis by hydrogen sulfide. Antioxid Redox Signal. 2019;30(2):184–97.

Article  CAS  PubMed  Google Scholar 

Luo Y, Lu S, Ai Q, Zhou P, Qin M, Sun G, et al. SIRT1/AMPK and Akt/eNOS signaling pathways are involved in endothelial protection of total aralosides of Aralia elata (Miq) Seem against high-fat diet-induced atherosclerosis in ApoE−/− mice. Phytother Res. 2019;33(3):768–78.

Article  CAS  PubMed  Google Scholar 

Abedimanesh N, Motlagh B, Abedimanesh S, Bathaie SZ, Separham A, Ostadrahimi A. Effects of crocin and saffron aqueous extract on gene expression of SIRT1, AMPK, LOX1, NF-κB, and MCP-1 in patients with coronary artery disease: a randomized placebo-controlled clinical trial. Phytother Res. 2020;34(5):1114–22.

Article  CAS  PubMed  Google Scholar 

He X, Zheng J, Liu C. Low serum level of sirtuin 1 predicts coronary atherosclerosis plaques during computed tomography angiography among an asymptomatic cohort. Coron Artery Dis. 2019;30(8):621–5.

Article  PubMed  Google Scholar 

Iside C, Scafuro M, Nebbioso A, Altucci L. SIRT1 activation by natural phytochemicals: An overview. Front Pharmacol. 2020;11:1225. https://doi.org/10.3389/fphar.2020.01225.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang F, Feng J, Zhang J, Kang X, Qian D. Quercetin modulates AMPK/SIRT1/NF-κB signaling to inhibit inflammatory/oxidative stress responses in diabetic high fat diet-induced atherosclerosis in the rat carotid artery. Exp Ther Med. 2020;20(6):1–1.

Google Scholar 

Jiang YH, Jiang LY, Wang YC, Ma DF, Li X. Quercetin attenuates atherosclerosis via modulating oxidized LDL-induced endothelial cellular senescence. Front Pharmacol. 2020;11(April):1–11.

Google Scholar 

Li C, Jiang S, Wang H, Wang Y, Han Y, Jiang J. Berberine exerts protective effects on cardiac senescence by regulating the Klotho/SIRT1 signaling pathway. Biomed Pharmacother. 2022;1:151.

Google Scholar 

Wu YZ, Zhang L, Wu ZX, Shan TT, Xiong C. Berberine ameliorates doxorubicin-induced cardiotoxicity via a SIRT1/p66Shc-mediated pathway. Oxidative Med Cell Longev. 2019;2019:2150394. https://doi.org/10.1155/2019/2150394.

Article  CAS  Google Scholar 

Yan L, Jia Q, Cao H, Chen C, Xing S, Huang Y, et al. Fisetin ameliorates atherosclerosis by regulating PCSK9 and LOX-1 in apoE−/− mice. Exp Ther Med. 2020;21(1):1–1.

Article  Google Scholar 

Yang W, Tian ZK, Yang HX, Feng ZJ, Sun JM, Jiang H, et al. Fisetin improves lead-induced neuroinflammation, apoptosis and synaptic dysfunction in mice associated with the AMPK/SIRT1 and autophagy pathway. Food Chem Toxicol. 2019;1:134.

Google Scholar 

Takano K, Tatebe J, Washizawa N, Morita T. Curcumin inhibits age-related vascular changes in aged mice fed a high-fat diet. Nutrients. 2018;10(10):1476. https://doi.org/10.3390/nu10101476.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ren B-C, Zhang Y-F, Liu S-S, Cheng X-J, Yang X, Cui X-G, et al. Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via Sirt1-Foxo1 and PI3K-Akt signalling pathways. J Cell Mol Med. 2020;24(21):12355–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ramírez-Zacarías JL, Castro-Muñozledo F, Kuri-Harcuch W. Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with oil red O. Histochemistry. 1992;97(6):493–7.

Article  PubMed  Google Scholar 

Chang HH, Chien CY, Chen KH, Huang SC, Chien CT. Catechins blunt the effects of oxLDL and its primary metabolite phosphatidylcholine hydroperoxide on endothelial dysfunction through inhibition of oxidative stress and restoration of eNOS in rats. Kidney Blood Press Res. 2018;42(5):919–32.

Article  Google Scholar 

Zhou L, Long J, Sun Y, Chen W, Qiu R, Yuan D. Resveratrol ameliorates atherosclerosis induced by high-fat diet and LPS in ApoE−/− mice and inhibits the activation of CD4+ T cells. Nutr Metab. 2020;17(1):41. https://doi.org/10.1186/s12986-020-00461-z.

Hada Y, Uchida HA, Wada J. Fisetin attenuates lipopolysaccharide-induced inflammatory responses in macrophage. Biomed Res Int. 2021;2021 https://doi.org/10.1155/2021/5570885.

Matacchione G, Gurău F, Silvestrini A, Tiboni M, Mancini L, Valli D, et al. Anti-SASP and anti-inflammatory activity of resveratrol, curcumin and β-caryophyllene association on human endothelial and monocytic cells. Biogerontology. 2021;22(3):297–313.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ramirez-Sanchez I, Mansour C, Navarrete-Yañez V, Ayala-Hernandez M, Guevara G, Castillo C, et al. (−)-Epicatechin induced reversal of endothelial cell aging and improved vascular function: underlying mechanisms. Food Funct. 2018;9(9):4802–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farrokhi E, Ghatreh-Samani K, Salehi-Vanani N, Mahmoodi A. The effect of resveratrol on expression of matrix metalloproteinase 9 and its tissue inhibitors in vascular smooth muscle cells. ARYA Atheroscler. 2018;14(4):157–62.

PubMed  PubMed Central  Google Scholar 

Hoseini A, Namazi G, Farrokhian A, Reiner Ž, Aghadavod E, Bahmani F, Asemi Z. The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease. Food Funct. 2019;10(9):6042–51. https://doi.org/10.1039/c9fo01075k.

Gonçalinho GHF, Kuwabara KL, de Oliveira Faria NF, da Silva Goes MF, Roggerio A, Avakian SD, Strunz CMC, de Padua Mansur A. Sirtuin 1 and vascular function in healthy women and men: a randomized clinical trial comparing the effects of energy restriction and resveratrol. Nutrients. 2023;15(13):2949. https://doi.org/10.3390/nu15132949.

Article  CAS  PubMed  PubMed Central  Google Scholar 

García-Martínez BI, Ruiz-Ramos M, Pedraza-Chaverri J, Santiago-Osorio E, Mendoza-Núñez VM. Effect of resveratrol on markers of oxidative stress and sirtuin 1 in elderly adults with type 2 diabetes. Int J Mol Sci. 2023;24(8):7422. https://doi.org/10.3390/ijms24087422.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghasemi E, Afzalpour ME, Nayebifar S. Combined high-intensity interval training and green tea supplementation enhance metabolic and antioxidant status in response to acute exercise in overweight women. The Journal of Physiological Sciences : JPS. 2020;70(1):31. https://doi.org/10.1186/s12576-020-00756-z.

Malhotra A, Bath S, Elbarbry F. An organ system approach to explore the antioxidative, anti-inflammatory, and cytoprotective actions of resveratrol, vol. 2015. Oxidative Medicine and Cellular Longevity: Hindawi Publishing Corporation; 2015.

Google Scholar 

Chachay VS, Kirkpatrick CMJ, Hickman IJ, Ferguson M, Prins JB, Martin JH. Resveratrol - pills to replace a healthy diet? Br J Clin Pharmacol. 2011;72:27–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nallasamy P, Kang ZY, Sun X, Anandh Babu PV, Liu D, Jia Z. Natural compound resveratrol attenuates TNF-alpha-induced vascular dysfunction in mice and human endothelial cells: the involvement of the NF-κB signaling pathway. Int J Mol Sci. 2021;22(22):12486. https://doi.org/10.3390/ijms222212486.

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