Huntington disease

YAC128 mice

Antisense oligonucleotides

Caspase-6

RNA splicing

RNA sequence analysis

MRI

amino acid position 586

artificial cerebrospinal fluid

antisense oligonucleotide

full-length human HTT

intracerebroventricular

magnetic resonance imaging

586-N-terminal HTT

rapid acquisition with relaxation enhancement

super resolution reconstruction

Raw RNAseq data generated in this paper are available in the GEO repository, GSE239312. The R script used for the analysis of the RNAseq data is available upon request.

© 2023 Published by Elsevier Inc.