Yang K, Wu Z, Zhang H, Zhang N, Wu W, Wang Z, Dai Z, Zhang X, Zhang L, Peng Y, et al. Glioma targeted therapy: insight into future of molecular approaches. Mol Cancer. 2022;21(1):39.
Article CAS PubMed PubMed Central Google Scholar
Li T, Li J, Chen Z, Zhang S, Li S, Wageh S, Al-Hartomy OA, Al-Sehemi AG, Xie Z, Kankala RK, et al. Glioma diagnosis and therapy: current challenges and nanomaterial-based solutions. J Control Release. 2022;352:338–70.
Article CAS PubMed Google Scholar
Schaff LR, Mellinghoff IK. Glioblastoma and other primary brain malignancies in adults: a review. JAMA. 2023;329(7):574–87.
Verdugo E, Puerto I, Medina MA. An update on the molecular biology of glioblastoma, with clinical implications and progress in its treatment. Cancer Commun. 2022;42(11):1083–111.
de Krijger I, Boersma V, Jacobs JJL. REV7: jack of many trades. Trends Cell Biol. 2021;31(8):686–701.
Article PubMed PubMed Central Google Scholar
Paniagua I, Tayeh Z, Falcone M, Hernandez Perez S, Cerutti A, Jacobs JJL. MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner. Nat Commun. 2022;13(1):5167.
Article CAS PubMed PubMed Central Google Scholar
de Krijger I, Fohr B, Perez SH, Vincendeau E, Serrat J, Thouin AM, Susvirkar V, Lescale C, Paniagua I, Hoekman L, et al. MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair. Nat Commun. 2021;12(1):5421.
Article PubMed PubMed Central Google Scholar
Kim JH, Kim HR, Patel R. Inactivation of Mad2B enhances apoptosis in human cervical cancer cell line upon cisplatin-induced DNA damage. Biomol Ther. 2023;31(3):340–9.
Vassel FM, Bian K, Walker GC, Hemann MT. Rev7 loss alters cisplatin response and increases drug efficacy in chemotherapy-resistant lung cancer. Proc Natl Acad Sci U S A. 2020;117(46):28922–4.
Article CAS PubMed PubMed Central Google Scholar
Hoshino A, Nakayama C, Jiang SX, Sakurai Y, Kato T, Numata Y, Umezawa A, Ichinoe M, Murakumo Y. Upregulation of REV7 correlates with progression of malignant melanoma. Pathol Int. 2022;72(1):14–24.
Article CAS PubMed Google Scholar
Ma L, Li X, Zhao X, Sun H, Kong F, Li Y, Sui Y, Xu F. Oxaliplatin promotes siMAD2L2-induced apoptosis in colon cancer cells. Mol Med Rep. 2021;24(3):1–9.
Niimi K, Murakumo Y, Watanabe N, Kato T, Mii S, Enomoto A, Asai M, Asai N, Yamamoto E, Kajiyama H, et al. Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells. Cancer Sci. 2014;105(5):545–52.
Article CAS PubMed PubMed Central Google Scholar
Hernando E, Nahle Z, Juan G, Diaz-Rodriguez E, Alaminos M, Hemann M, Michel L, Mittal V, Gerald W, Benezra R, et al. Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature. 2004;430(7001):797–802.
Article CAS PubMed Google Scholar
Alonso MM, Alemany R, Fueyo J, Gomez-Manzano C. E2F1 in gliomas: a paradigm of oncogene addiction. Cancer Lett. 2008;263(2):157–63.
Article CAS PubMed Google Scholar
Engelmann D, Putzer BM. The dark side of E2F1: in transit beyond apoptosis. Cancer Res. 2012;72(3):571–5.
Article CAS PubMed Google Scholar
Zhou J, Tong F, Zhao J, Cui X, Wang Y, Wang G, Kang C, Liu X, Wang Q. Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance. Cancer Biol Med. 2023;20(5):385–400.
Article PubMed PubMed Central Google Scholar
Dhanasekaran R, Deutzmann A, Mahauad-Fernandez WD, Hansen AS, Gouw AM, Felsher DW. The MYC oncogene—the grand orchestrator of cancer growth and immune evasion. Nat Rev Clin Oncol. 2022;19(1):23–36.
Article CAS PubMed Google Scholar
Das SK, Lewis BA, Levens D. MYC: a complex problem. Trends Cell Biol. 2023;33(3):235–46.
Article CAS PubMed Google Scholar
Duffy MJ, O’Grady S, Tang M, Crown J. MYC as a target for cancer treatment. Cancer Treat Rev. 2021;94:102154.
Article CAS PubMed Google Scholar
Edwards-Hicks J, Su H, Mangolini M, Yoneten KK, Wills J, Rodriguez-Blanco G, Young C, Cho K, Barker H, Muir M, et al. MYC sensitises cells to apoptosis by driving energetic demand. Nat Commun. 2022;13(1):4674.
Article CAS PubMed PubMed Central Google Scholar
Chen H, Liu H, Qing G. Targeting oncogenic Myc as a strategy for cancer treatment. Signal Transduct Target Ther. 2018;3:5.
Article PubMed PubMed Central Google Scholar
Cencioni C, Scagnoli F, Spallotta F, Nasi S, Illi B. The “superoncogene” myc at the crossroad between metabolism and gene expression in glioblastoma multiforme. Int J Mol Sci. 2023;24(4):4217.
Article CAS PubMed PubMed Central Google Scholar
Li J, Liao T, Liu H, Yuan H, Ouyang T, Wang J, Chai S, Li J, Chen J, Li X, et al. Hypoxic glioma stem cell-derived exosomes containing Linc01060 promote progression of glioma by regulating the MZF1/c-Myc/HIF1alpha axis. Cancer Res. 2021;81(1):114–28.
Article CAS PubMed Google Scholar
Llombart V, Mansour MR. Therapeutic targeting of “undruggable” MYC. EBioMedicine. 2022;75:103756.
Article CAS PubMed Google Scholar
Chen Z, Wang HW, Wang S, Fan L, Feng S, Cai X, Peng C, Wu X, Lu J, Chen D, et al. USP9X deubiquitinates ALDH1A3 and maintains mesenchymal identity in glioblastoma stem cells. J Clin Invest. 2019;129(5):2043–55.
Article PubMed PubMed Central Google Scholar
Zhang Q, Chen Z, Tang Q, Wang Z, Lu J, You Y, Wang H. USP21 promotes self-renewal and tumorigenicity of mesenchymal glioblastoma stem cells by deubiquitinating and stabilizing FOXD1. Cell Death Dis. 2022;13(8):712.
Article CAS PubMed PubMed Central Google Scholar
Hersh AM, Gaitsch H, Alomari S, Lubelski D, Tyler BM. Molecular pathways and genomic landscape of glioblastoma stem cells: opportunities for targeted therapy. Cancers. 2022;14(15):3743.
Article CAS PubMed PubMed Central Google Scholar
Wang Z, Zhang H, Xu S, Liu Z, Cheng Q. The adaptive transition of glioblastoma stem cells and its implications on treatments. Signal Transduct Target Ther. 2021;6(1):124.
Article CAS PubMed PubMed Central Google Scholar
Peng L, Fu J, Chen Y, Ming Y, He H, Zeng S, Zhong C, Chen L. Transcription factor SNAI2 exerts pro-tumorigenic effects on glioma stem cells via PHLPP2-mediated Akt pathway. Cell Death Dis. 2022;13(6):516.
Article CAS PubMed PubMed Central Google Scholar
Marcotte R, Sayad A, Brown KR, Sanchez-Garcia F, Reimand J, Haider M, Virtanen C, Bradner JE, Bader GD, Mills GB, et al. Functional genomic landscape of human breast cancer drivers, vulnerabilities, and resistance. Cell. 2016;164(1–2):293–309.
Article CAS PubMed PubMed Central Google Scholar
Tsherniak A, Vazquez F, Montgomery PG, Weir BA, Kryukov G, Cowley GS, Gill S, Harrington WF, Pantel S, Krill-Burger JM, et al. Defining a cancer dependency map. Cell. 2017;170(3):564–76.
Article CAS PubMed PubMed Central Google Scholar
Wang LB, Karpova A, Gritsenko MA, Kyle JE, Cao S, Li Y, Rykunov D, Colaprico A, Rothstein JH, Hong R, et al. Proteogenomic and metabolomic characterization of human glioblastoma. Cancer Cell. 2021;39(4):509–28.
Article CAS PubMed PubMed Central Google Scholar
Uhlen M, Fagerberg L, Hallstrom BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson A, Kampf C, Sjostedt E, Asplund A, et al. Proteomics tissue-based map of the human proteome. Science. 2015;347(6220):1260419.
Sun D, Wang J, Han Y, Dong X, Ge J, Zheng R, Shi X, Wang B, Li Z, Ren P, et al. TISCH: a comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment. Nucleic Acids Res. 2021;49(D1):D1420–30.
Article CAS PubMed Google Scholar
Yuan H, Yan M, Zhang G, Liu W, Deng C, Liao G, Xu L, Luo T, Yan H, Long Z, et al. CancerSEA: a cancer single-cell state atlas. Nucleic Acids Res. 201
Comments (0)