Possible relationship between primary aldosteronism and small vessel disease

Naruse M, Katabami T, Shibata H, Sone M, Takahashi K, Tanabe A, et al. Japan Endocrine Society clinical practice guideline for the diagnosis and management of primary aldosteronism 2021. Endocr J. 2022;69:327–59.

Article  PubMed  Google Scholar 

Haze T, Ozawa M, Kawano R, Haruna A, Ohki Y, Suzuki S, et al. Effect of the interaction between the visceral-to-subcutaneous fat ratio and aldosterone on cardiac function in patients with primary aldosteronism. Hypertens Res. 2023;46:1132–44.

Article  CAS  PubMed  Google Scholar 

Haze T, Hatakeyama M, Komiya S, Kawano R, Ohki Y, Suzuki S, et al. Association of the ratio of visceral-to-subcutaneous fat volume with renal function among patients with primary aldosteronism. Hypertens Res. 2021;44:1341–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Neves MF, Cunha AR, Cunha MR, Gismondi RA, Oigman W. The role of renin-angiotensin-aldosterone system and its new components in arterial stiffness and vascular aging. High Blood Press Cardiovasc Prev. 2018;25:137–45.

Article  CAS  PubMed  Google Scholar 

Ohno Y, Sone M, Inagaki N, Yamasaki T, Ogawa O, Takeda Y, et al. Prevalence of cardiovascular disease and its risk factors in primary aldosteronism: a multicenter study in Japan. Hypertension. 2018;71:530–37.

Article  CAS  PubMed  Google Scholar 

Hong N, Kim KJ, Yu MH, Jeong SH, Lee S, Lim JS, et al. Risk of dementia in primary aldosteronism compared with essential hypertension: a nationwide cohort study. Alzheimers Res Ther. 2023;15:136.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haze T, Hirawa N, Yano Y, Tamura K, Kurihara I, Kobayashi H, et al. Association of aldosterone and blood pressure with the risk for cardiovascular events after treatments in primary aldosteronism. Atherosclerosis. 2021;324:84–90.

Article  CAS  PubMed  Google Scholar 

Haze T, Yano Y, Hatano Y, Tamura K, Kurihara I, Kobayashi H, et al. Association of achieved blood pressure after treatment for primary aldosteronism with long-term kidney function. J Hum Hypertens. 2022;36:904–10.

Article  CAS  PubMed  Google Scholar 

Hamanaka G, Ohtomo R, Takase H, Lok J, Arai K. White-matter repair: interaction between oligodendrocytes and the neurovascular unit. Brain Circ. 2018;4:118–23.

Article  PubMed  PubMed Central  Google Scholar 

Wardlaw JM, Smith C, Dichgans M. Small vessel disease: mechanisms and clinical implications. Lancet Neurol. 2019;18:684–96.

Article  PubMed  Google Scholar 

Bokura H, Saika R, Yamaguchi T, Nagai A, Oguro H, Kobayashi S, et al. Microbleeds are associated with subsequent hemorrhagic and ischemic stroke in healthy elderly individuals. Stroke. 2011;42:1867–71.

Article  CAS  PubMed  Google Scholar 

Lee BC, Tsai HH, Chen ZW, Chang CC, Huang JZ, Chang YY, et al. Aldosteronism is associated with more severe cerebral small vessel disease in hypertensive intracerebral hemorrhage. Hypertens Res. 2023. https://doi.org/10.1038/s41440-023-01458-w.

Yuan Y, Li N, Liu Y, Zhu Q, Heizhati M, Zhang W, et al. Positive association between plasma aldosterone concentration and white matter lesions in patients with hypertension. Front Endocrinol (Lausanne). 2021;12:753074. https://doi.org/10.3389/fendo.2021.753074.

Article  PubMed  Google Scholar 

Dinh QN, Young MJ, Evans MA, Drummond GR, Sobey CG, Chrissobolis S. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res. 2016;1637:146–53.

Article  CAS  PubMed  Google Scholar 

Abbas K, Lu Y, Bavishi S, Mishra N, TomThundyil S, Sawant SA, et al. A simple review of small vessel disease manifestation in the brain, retina, and kidneys. J Clin Med. 2022;11:5546.

Article  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif