Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6

Keywords

Prion disease

Creutzfeldt-Jakob disease

SNARE

Syntaxin-6

Incubation period

AbbreviationssCJD

sporadic Creutzfeldt-Jakob disease

PrPC

cellular prion protein

PSP

progressive supranuclear palsy

SNARE

soluble N-ethylmaleimide-sensitive factor attachment protein receptor

eQTL

expression quantitative trait loci

IMPC

International Mouse Phenotyping Consortium

GWAS

genome wide association study

Data availability

All data is available in Supplementary Table S3-S8. Original images of Western blots are available in Supplementary Fig. 7.

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