Association of mTOR Pathway and Conformational Alterations in C-Reactive Protein in Neurodegenerative Diseases and Infections

Agrawal A, Singh PP, Bottazzi B et al (2009) Pattern recognition by pentraxins. Adv Exp Med Biol 653:98–116. https://doi.org/10.1007/978-1-4419-0901-5_7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Agarwal D, Kumari R, Ilyas A et al (2021) Crosstalk between epigenetics and mTOR as a gateway to new insights in pathophysiology and treatment of Alzheimer's disease. Int J Biol Macromol 192:895–903. https://doi.org/10.1016/j.ijbiomac.2021.10.026

Ahmad I, Hoque M, Alam SSM et al (2023) Curcumin and plumbagin synergistically target the PI3K/Akt/mTOR pathway: a prospective role in cancer treatment. Int J Mol Sci 24(7):6651. https://doi.org/10.3390/ijms24076651

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali N (2020) Elevated level of C-reactive protein may be an early marker to predict risk for severity of COVID-19. J Med Virol 92(11):2409–2411. https://doi.org/10.1002/jmv.26097

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anchah L, Hassali MA, Lim MS, Ibrahim MI, Sim KH, Ong TK (2017) Health related quality of life assessment in acute coronary syndrome patients: the effectiveness of early phase I cardiac rehabilitation. Health Qual Life Outcomes 15(1):10. https://doi.org/10.1186/s12955-016-0583-7

Article  PubMed  PubMed Central  Google Scholar 

Ansar W (2020) Multiple faces of C-reactive protein: structure-function relationships. Clin Sign C-React Protein 1:1–34

Google Scholar 

Ansar W, Ghosh S, Ansar W, Ghosh S (2016) CRP: historical perspective, structure, evolution, synthesis, clinical and biological functions. Biol React Protein Health Dis 1:33–43

Article  Google Scholar 

Araki K, Turner AP, Shaffer VO et al (2009) mTOR regulates memory CD8 T-cell differentiation. Nature 460(7251):108–112. https://doi.org/10.1038/nature08155

Article  CAS  PubMed  PubMed Central  Google Scholar 

Awogbindin IO, Ben-Azu B, Olusola BA et al (2021) Microglial implications in SARS-CoV-2 infection and COVID-19: Lessons from viral RNA neurotropism and possible relevance to Parkinson’s disease. Front Cell Neurosci. https://doi.org/10.3389/fncel.2021.670298

Article  PubMed  PubMed Central  Google Scholar 

Aziz M, Fatima R, Assaly R (2020) Elevated interleukin-6 and severe COVID-19: a meta-analysis. J Med Virol 92(11):2283–2285. https://doi.org/10.1002/jmv.25948

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baldi S, Pinna GD, Mombaruzzo P et al (2008) C-reactive protein correlates with tissue oxygen availability in patients with stable COPD. Int J COPD 3(4):745–751. https://doi.org/10.2147/copd.s3819

Article  CAS  Google Scholar 

Balin BJ, Gérard HC, Arking EJ, Appelt DM, Branigan PJ et al (1998) (1998) Identification and localization of Chlamydia pneumoniae in the Alzheimer’s brain. Med Microbiol Immunol 187(1):23–42. https://doi.org/10.1007/s004300050071

Article  CAS  PubMed  Google Scholar 

Bansal T, Pandey A et al (2014) C-reactive protein (CRP) and its association with periodontal disease: a brief review. J Clin Diagn Res JCDR 8(7):21–24. https://doi.org/10.7860/JCDR/2014/8355.4646

Article  CAS  Google Scholar 

Behl T, Rana T, Sehgal A, et al (2022) Phytochemicals targeting nitric oxide signaling in neurodegenerative diseases. Nitric oxide.

Bohmwald K, Gálvez NMS, Canedo-Marroquín G et al (2019) Contribution of cytokines to tissue damage during human respiratory syncytial virus infection. Front Immunol 10:1–16. https://doi.org/10.3389/fimmu.2019.00452

Article  Google Scholar 

Boncler M, Wu Y, Watala C (2019) The multiple faces of C-reactive protein: physiological and pathophysiological implications in cardiovascular disease. Molecules 24(11):2062

Article  CAS  PubMed  PubMed Central  Google Scholar 

Braig D, Nero TL, Koch HG et al (2017) Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites. Nat Commun. https://doi.org/10.1038/ncomms14188

Article  PubMed  PubMed Central  Google Scholar 

Bunton-Stasyshyn RKA, Saccon RA, Fratta P et al (2015) SOD1 function and its implications for amyotrophic lateral sclerosis pathology: new and renascent themes. Neuroscientist 21(5):519–529. https://doi.org/10.1177/1073858414561795

Article  CAS  PubMed  Google Scholar 

Chang MK, Binder CJ, Torzewski M, Witztum JL (2002) C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: phosphorylcholine of oxidized phospholipids. Proc Natl Acad Sci USA 99(20):13043–13048. https://doi.org/10.1073/pnas.192399699

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chien JY, Hsueh PR, Cheng WC, Yu CJ, Yang PC (2006) Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome. Respirology 11(6):715–722. https://doi.org/10.1111/j.1440-1843.2006.00942.x

Article  PubMed  PubMed Central  Google Scholar 

Corradetti MN, Guan KL (2006) Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Oncogene 25(48):6347–6360

Article  CAS  PubMed  Google Scholar 

Crino PB (2016) The mTOR signalling cascade: paving new roads to cure neurological disease. Nat Rev Neurol 12(7):379–392. https://doi.org/10.1038/nrneurol.2016.81

Article  CAS  PubMed  Google Scholar 

Das S, Roy S, Kaul S et al (2014) CRP gene (1059G>C) polymorphism and its plasma levels in ischemic stroke and hemorrhagic stroke in a South Indian population. Inflammation 37(5):1683–1688. https://doi.org/10.1007/s10753-014-9897-y

Article  CAS  PubMed  Google Scholar 

Das A, Reis F, Maejima Y et al. (2017). mTOR signaling in cardiometabolic disease, cancer, and aging. In: Oxidative medicine and cellular longevity. https://doi.org/10.1155/2017/6018675

De Chiara G, Marcocci ME, Sgarbanti R, Civitelli L et al (2012) Infectious agents and neurodegeneration. Mol Neurobiol 46(3):614–638. https://doi.org/10.1007/s12035-012-8320-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

De-Paula VJ, Radanovic M, Diniz BS et al (2012) Alzheimer’s disease. Subcell Biochem 65:329–352. https://doi.org/10.1007/978-94-007-5416-4_14

Article  CAS  PubMed  Google Scholar 

Devaraj S, du Clos TW, Jialal I (2005) Binding and internalization of C-reactive protein by Fcgamma receptors on human aortic endothelial cells mediates biological effects. Arterioscler Thromb Vasc Biol 25(7):1359–1363. https://doi.org/10.1161/01.ATV.0000168573.10844.ae

Article  CAS  PubMed  Google Scholar 

Du Clos TW (2013) Pentraxins: structure, function, and role in inflammation. ISRN Inflamm 2013:1–22. https://doi.org/10.1155/2013/379040

Article  CAS  Google Scholar 

Duong T, Nikolaeva M, Acton PJ (1997) C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer’s disease. Brain Res 749(1):152–156. https://doi.org/10.1016/S0006-8993(96)01359-5

Article  CAS  PubMed  Google Scholar 

Eisenhardt SU, Thiele JR, Bannasch H et al (2009) C-reactive protein: how conformational changes influence inflammatory properties. Cell Cycle 8(23):3885–3892. https://doi.org/10.4161/cc.8.23.10068

Article  CAS  PubMed  Google Scholar 

Francois A, Verite J, Bilan AR et al. (2016) The mTOR signaling pathway in neurodegenerative diseases. In: Molecules to medicine with MTOR: translating critical pathways into novel therapeutic strategies, pp 85–104. https://doi.org/10.1016/B978-0-12-802733-2.00011-6

Gao R, Wang L, Bai T et al (2017) C-reactive protein mediating immunopathological lesions: a potential treatment option for severe influenza A diseases. EBioMedicine 22:133–142

Article  PubMed  PubMed Central  Google Scholar 

Gao Y, Li T, Han M et al (2020) Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. J Med Virol 92(7):791–796. https://doi.org/10.1002/jmv.25770

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gatti P, Ilamathi HS, Todkar K et al (2020) Mitochondria targeted viral replication and survival strategies—prospective on SARS-CoV-2. Front Pharmacol. https://doi.org/10.3389/fphar.2020.578599

Article  PubMed  PubMed Central  Google Scholar 

Gendrel D, Raymond J, Coste J et al (1999) Comparison of procalcitonin with C-reactive protein, interleukin 6 and interferon-alpha for differentiation of bacterial vs viral infections. Pediatr Infect Dis J 18(10):875–881. https://doi.org/10.1097/00006454-199910000-00008

Article  CAS  PubMed  Google Scholar 

Gong C, Wei D, Wang Y, Ma J et al (2016) A meta-analysis of C-reactive protein in patients with Alzheimer’s disease. Am J Alzheimers Dis Other Demen 31(3):194–200. https://doi.org/10.1177/1533317515602087

Article  PubMed  Google Scholar 

Hao S, Wang Y, Gao G, Li Z (2017) Hepatitis B virus upregulates the expression of C-reactive protein both in vivo and in vitro. Ann Clin Lab Sci 47(4):432–435

CAS  PubMed  Google Scholar 

Hara K, Maruki Y, Long X et al (2002) Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110(2):177–189

Article  CAS  PubMed 

Comments (0)

No login
gif