Metastasis suppressor genes and their role in the tumor microenvironment

Ganesh, K., & Massagué, J. (2021). Targeting metastatic cancer. Nature Medicine, 27(1), 34–44. https://doi.org/10.1038/S41591-020-01195-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lyden, D., Ghajar, C. M., Correia, A. L., et al. (2022). Metastasis. Cancer Cell, 40(8), 787–791. https://doi.org/10.1016/j.ccell.2022.07.010

Article  CAS  PubMed  PubMed Central  Google Scholar 

Massagué, J., & Obenauf, A. C. (2016). Metastatic colonization by circulating tumour cells. Nature, 529(7586), 298–306. https://doi.org/10.1038/nature17038

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sosa, M. S., Bravo-Cordero, J. J. (2020). Understanding the mechanistic features of cancer metastasis. Cancer Reports, 3(1). https://doi.org/10.1002/CNR2.1238

Di Martino, J. S., Akhter, T., & Bravo-Cordero, J. J. (2021). Remodeling the ECM: Implications for metastasis and tumor dormancy. Cancers, 13(19), 4916. https://doi.org/10.3390/CANCERS13194916

Article  PubMed  PubMed Central  Google Scholar 

Horak, C. E., Lee, J. H., Marshall, J. C., Shreeve, S. M., & Steeg, P. S. (2008). The role of metastasis suppressor genes in metastatic dormancy. APMIS, 116(7–8), 586–601. https://doi.org/10.1111/j.1600-0463.2008.01027.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cairns, J. (1975). Mutation selection and the natural history of cancer. Nature, 255(5505), 197–200. https://doi.org/10.1038/255197A0

Article  CAS  PubMed  Google Scholar 

Greaves, M., & Maley, C. C. (2012). Clonal evolution in cancer. Nature, 481(7381), 306. https://doi.org/10.1038/NATURE10762

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rhim, A. D., Mirek, E. T., Aiello, N. M., et al. (2012). EMT and dissemination precede pancreatic tumor formation. Cell, 148(1–2), 349–361. https://doi.org/10.1016/j.cell.2011.11.025

Article  CAS  PubMed  Google Scholar 

Hosseini, H., Obradovic, M. M. S., Hoffmann, M., et al. (2016). Early dissemination seeds metastasis in breast cancer. Nature, 540(7634), 552–558. https://doi.org/10.1038/nature20785

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gupta, P. B., Mani, S., Yang, J., Hartwell, K., & Weinberg, R. A. (2005). The evolving portrait of cancer metastasis. Cold Spring Harb Symp Quant Biol, 70, 291–7. https://doi.org/10.1101/sqb.2005.70.033

Article  CAS  PubMed  Google Scholar 

Pantel, K., Brakenhoff, R. H., & Brandt, B. (2008). Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nature Reviews Cancer, 8(5), 329–340. https://doi.org/10.1038/nrc2375

Article  CAS  Google Scholar 

Klein, C. A. (2009). Parallel progression of primary tumours and metastases. Nature Reviews Cancer, 9(4), 302–312. https://doi.org/10.1038/nrc2627

Article  CAS  PubMed  Google Scholar 

Hu, Z., Ding, J., Ma, Z., et al. (2019). Quantitative evidence for early metastatic seeding in colorectal cancer. Nature Genetics, 51(7), 1113–1122. https://doi.org/10.1038/s41588-019-0423-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ray, A., Callaway, M. K., Rodríguez-Merced, N. J., et al., (2022). Stromal architecture directs early dissemination in pancreatic ductal adenocarcinoma. JCI Insight, 7(3). https://doi.org/10.1172/JCI.INSIGHT.150330

Di Martino, J. S., Akhter, T., & Bravo-Cordero, J. J. (2021). Remodeling the ECM: Implications for metastasis and tumor dormancy. Cancers (Basel)., 13(19), 4916. https://doi.org/10.3390/CANCERS13194916

Article  PubMed  PubMed Central  Google Scholar 

Quail, D. F., & Joyce, J. A. (2013). Microenvironmental regulation of tumor progression and metastasis. Nature Medicine, 19(11), 1423–1437. https://doi.org/10.1038/NM.3394

Article  CAS  PubMed  PubMed Central  Google Scholar 

Friedl, P., & Gilmour, D. (2009). Collective cell migration in morphogenesis, regeneration and cancer. Nature Reviews Molecular Cell Biology, 10(7), 445–457. https://doi.org/10.1038/NRM2720

Article  CAS  PubMed  Google Scholar 

Mukherjee, A., & Bravo-Cordero, J. J. (2023). Regulation of dormancy during tumor dissemination: The role of the ECM. Cancer Metastasis Reviews., 42, 99–112. https://doi.org/10.1007/s10555-023-10094-2. Published online March 1, 2023.

Article  PubMed  PubMed Central  Google Scholar 

Bravo-Cordero, J. J., Hodgson, L., & Condeelis, J. (2012). Directed cell invasion and migration during metastasis. Current Opinion in Cell Biology, 24(2), 277–283. https://doi.org/10.1016/j.ceb.2011.12.004

Article  CAS  PubMed  Google Scholar 

Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009). Epithelial-mesenchymal transitions in development and disease. Cell, 139(5), 871–890. https://doi.org/10.1016/J.CELL.2009.11.007

Article  CAS  PubMed  Google Scholar 

Nieto, M. A., Huang, R. Y. Y. J., Jackson, R. A. A., & Thiery, J. P. P. (2016). EMT: 2016. Cell, 166(1), 21–45. https://doi.org/10.1016/J.CELL.2016.06.028

Article  CAS  PubMed  Google Scholar 

Mondal, C., Gacha-Garay, M. J., Larkin, K. A., et al. (2022). A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGF-β2 signaling. Cell Reports 40 (12). https://doi.org/10.1016/J.CELREP.2022.111358/ATTACHMENT/AD571673-CC1F-4AC5-9309-522AAC0B5913/MMC2

Mondal, C., Di Martino, J. S., & Bravo-Cordero, J. J. (2021). Actin dynamics during tumor cell dissemination. International Review of Cell and Molecular Biology, 360, 65–98. https://doi.org/10.1016/BS.IRCMB.2020.09.004

Article  CAS  PubMed  Google Scholar 

Gligorijevic, B., Wyckoff, J., Yamaguchi, H., Wang, Y., Roussos, E. T., & Condeelis, J. (2012). N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors. Journal of Cell Science, 125(Pt 3), 724–734. https://doi.org/10.1242/JCS.092726

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharma, V. P., Eddy, R., Entenberg, D., Kai, M., Gertler, F. B., & Condeelis, J. (2013). Tks5 and SHIP2 regulate invadopodium maturation, but not initiation, in breast carcinoma cells. Current Biology, 23(21), 2079–2089. https://doi.org/10.1016/J.CUB.2013.08.044

Article  CAS  PubMed  Google Scholar 

Oser, M., & Condeelis, J. (2009). The cofilin activity cycle in lamellipodia and invadopodia. Journal of Cellular Biochemistry, 108(6), 1252. https://doi.org/10.1002/JCB.22372

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oser, M., Yamaguchi, H., Mader, C. C., et al. (2009). Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. Journal of Cell Biology, 186(4), 571–587. https://doi.org/10.1083/JCB.200812176

Article  CAS  PubMed  PubMed Central  Google Scholar 

Risson, E., Nobre, A. R., Maguer-Satta, V., & Aguirre-Ghiso, J. A. (2020). The current paradigm and challenges ahead for the dormancy of disseminated tumor cells. Nature Cancer., 1(7), 672–680. https://doi.org/10.1038/s43018-020-0088-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sosa, M. S., Bragado, P., & Aguirre-Ghiso, J. A. (2014). Mechanisms of disseminated cancer cell dormancy: An awakening field. Nature Reviews Cancer, 14(9), 611–622. https://doi.org/10.1038/NRC3793

Article  CAS  PubMed Central  Google Scholar 

Sosa, M. S., Bragado, P., & Aguirre-Ghiso, J. A. (2014). Mechanisms of disseminated cancer cell dormancy: An awakening field. Nature Reviews Cancer, 14(9), 611–622. https://doi.org/10.1038/nrc3793

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giancotti, F. G. (2013). Mechanisms governing metastatic dormancy and reactivation. Cell, 155(4), 750. https://doi.org/10.1016/j.cell.2013.10.029

Article  CAS  PubMed  PubMed Central  Google Scholar 

Butturini, E., de Prati, A. C., Boriero, D., & Mariotto, S. (2019). Tumor dormancy and interplay with hypoxic tumor microenvironment. International Journal of Molecular Sciences., 20(17), 4305. https://doi.org/10.3390/IJMS20174305

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferrer, A., Roser, C. T., El-Far, M. H., et al. (2020). Hypoxia-mediated changes in bone marrow microenvironment in breast cancer dormancy. Cancer Letters, 488, 9–17. https://doi.org/10.1016/J.CANLET.2020.05.026

Article  CAS  PubMed  Google Scholar 

Ghajar, C. M., Peinado, H., Mori, H., et al. (2013). The perivascular niche regulates breast tumour dormancy. Nature Cell Biology, 15(7), 807–817. https://doi.org/10.1038/NCB2767

Comments (0)

No login
gif