Cancer and Autism: How PTEN Mutations Degrade Function at the Membrane and Isoform Expression in the Human Brain
Keywords
neurodevelopmental disorders
autism spectrum disorder
cancer
allosteric mutations
tumor suppressor
AbbreviationsPTEN
phosphatase and tensin homolog
PI3K
phosphoinositide 3-kinase
PIP3
phosphatidylinositol 3,4,5-trisphosphate
PIP2
phosphatidylinositol 4,5-bisphosphate
NDD
neurodevelopmental disorder
PHTS
PTEN hamartoma tumor syndrome
BRRS
Bannayan-Riley-Ruvalcaba syndrome
ASD
autism spectrum disorder
ADHD
attention-deficit/hyperactivity disorder
IDR
intrinsically disordered region
PTM
posttranslational modification
Data availability
Data will be made available on request.
© 2023 Published by Elsevier Ltd.
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