AlYousef A, AlSahow A, AlHelal B, Alqallaf A, Abdallah E, Abdellatif M, Nawar H, Elmahalawy R (2020) Glomerulonephritis histopathological pattern change. BMC Nephrol 21(1):186. https://doi.org/10.1186/s12882-020-01836-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Avraham S, Korin B, Chung JJ, Oxburgh L, Shaw AS (2021) The mesangial cell - the glomerular stromal cell. Nat Rev Nephrol 17(12):855–864. https://doi.org/10.1038/s41581-021-00474-8

Article  PubMed  Google Scholar 

Bakshi A, Moin M, Gayatri MB, Reddy ABM, Datla R, Madhav MS, Kirti PB (2023) Involvement of target of rapamycin (TOR) signaling in the regulation of crosstalk between ribosomal protein small subunit 6 kinase-1 (RPS6K-1) and ribosomal proteins. Plants (basel) 12(1):176. https://doi.org/10.3390/plants12010176

Article  CAS  PubMed  Google Scholar 

Barba C, Benoit B, Bres E, Chanon S, Vieille-Marchiset A, Pinteur C, Pesenti S, Glorieux G, Picard C, Fouque D, Soulage CO, Koppe L (2021) A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease. Sci Rep 11(1):19184. https://doi.org/10.1038/s41598-021-98718-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Soysa AKH, Langaas M, Jakic A, Shojaee-Moradie F, Umpleby AM, Grill V, Mostad IL (2021) The fat mass and obesity-associated (FTO) gene allele rs9939609 and glucose tolerance, hepatic and total insulin sensitivity, in adults with obesity. PloS One 16(3):e0248247. https://doi.org/10.1371/journal.pone.0248247

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng FZ, Gong WY, Li SY, Deng YH (2022) Inhibitory effect of resveratrol on LPS-induced glomerular mesangial cells proliferation and TGF-β1 expression via sphingosine kinase 1 pathway. Chin J Integr Med 29(6):500–507. https://doi.org/10.1007/s11655-022-3530-y

Article  CAS  PubMed  Google Scholar 

Gao JR, Shi MM, Jiang H, Zhu XL, Wei LB, Qin XJ (2022) MicroRNA-339-5p inhibits lipopolysaccharide-induced rat mesangial cells by regulating the Syk/Ras/c-Fos pathway. Naunyn Schmiedebergs Arch Pharmacol 395(9):1075–1085. https://doi.org/10.1007/s00210-022-02261-z

Article  CAS  PubMed  Google Scholar 

He Z, Houghton PJ, Williams TM, Shen C (2021) Regulation of DNA duplication by the mTOR signaling pathway. Cell Cycle (Georgetown, Tex) 20(8):742–751. https://doi.org/10.1080/15384101.2021.1897271

Article  CAS  PubMed  Google Scholar 

Huo YB, Gao X, Peng Q, Nie Q, Bi W (2022) Dihydroartemisinin alleviates AngII-induced vascular smooth muscle cell proliferation and inflammatory response by blocking the FTO/NR4A3 axis. Inflamm Res 71(2):243–253. https://doi.org/10.1007/s00011-021-01533-3

Article  CAS  PubMed  Google Scholar 

Kisly I, Tamm T (2023) Archaea/eukaryote-specific ribosomal proteins - guardians of a complex structure. Comput Struct Biotechnol J 21:1249–1261. https://doi.org/10.1016/j.csbj.2023.01.037

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Li Y, Wang Y, He X (2022) The m6A demethylase FTO promotes renal epithelial-mesenchymal transition by reducing the m6A modification of lncRNA GAS5. Cytokine 159:156000. https://doi.org/10.1016/j.cyto.2022.156000

Article  CAS  PubMed  Google Scholar 

Liu H, Li W, He Q, Xue J, Wang J, Xiong C, Pu X, Nie Z (2017) Mass spectrometry imaging of kidney tissue sections of rat subjected to unilateral ureteral obstruction. Sci Rep 7:41954. https://doi.org/10.1038/srep41954

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu B, Lin J, Bai L, Zhou Y, Lu R, Zhang P, Chen D, Li H, Song J, Liu X, Wu Y, Wu J, Liang C, Zhou J (2019) Paeoniflorin inhibits mesangial cell proliferation and inflammatory response in rats with mesangial proliferative glomerulonephritis through PI3K/AKT/GSK-3β pathway. Front Pharmacol 10:978. https://doi.org/10.3389/fphar.2019.00978

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu XY, Wang YH, Wang J, Quan JK, Li XD, Guan KP (2023) The role of CSE1L silencing in the regulation of proliferation and apoptosis via the AMPK/mTOR signaling pathway in chronic myeloid leukemia. Hematology 28(1):1–9. https://doi.org/10.1080/16078454.2022.2161201

Article  CAS  PubMed  Google Scholar 

Miao X, Xiang Y, Mao W, Chen Y, Li Q, Fan B (2020) TRIM27 promotes IL-6-induced proliferation and inflammation factor production by activating STAT3 signaling in HaCaT cells. Am J Physiol Cell Physiol 318(2):C272–C281. https://doi.org/10.1152/ajpcell.00314.2019

Article  CAS  PubMed  Google Scholar 

Øvrehus MA, Bruheim P, Ju W, Zelnick LR, Langlo KA, Sharma K, de Boer IH, Hallan SI (2018) Gene expression studies and targeted metabolomics reveal disturbed serine, methionine, and tyrosine metabolism in early hypertensive nephrosclerosis. Kidney Int Rep 4(2):321–333. https://doi.org/10.1016/j.ekir.2018.10.007

Article  PubMed  PubMed Central  Google Scholar 

Shen J, Wu Q, Liang T, Zhang J, Bai J, Yuan M, Shen P (2021) TRIM40 inhibits IgA1-induced proliferation of glomerular mesangial cells by inactivating NLRP3 inflammasome through ubiquitination. Mol Immunol 140:225–232. https://doi.org/10.1016/j.molimm.2021.10.012

Article  CAS  PubMed  Google Scholar 

Sun PF, Tian T, Chen LN, Fu RG, Xu SS, Ai H, Wang B, Zhang J, Si RY, Chai Z, Cooper ME, Ren ST (2018) Ultrasound combined with microbubbles enhances the effects of methylprednisolone in lipopolysaccharide-induced human mesangial cells. J Pharmacol Exp Ther 365(3):476–484. https://doi.org/10.1124/jpet.117.246223

Article  CAS  PubMed  Google Scholar 

Sun Q, Geng H, Zhao M, Li Y, Chen X, Sha Q, Lai P, Tang D, Yang D, Liang J, Guo M (2022) FTO-mediated m6 A modification of SOCS1 mRNA promotes the progression of diabetic kidney disease. Clin Transl Med 12(6):e942. https://doi.org/10.1002/ctm2.942

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsai KD, Lee WX, Chen W, Chen BY, Chen KL, Hsiao TC, Wang SH, Lee YJ, Liang SY, Shieh JC, Lin TH (2018) Upregulation of PRMT6 by LPS suppresses klotho expression through interaction with NF-κB in glomerular mesangial cells. J Cell Biochem 119(4):3404–3416. https://doi.org/10.1002/jcb.26511

Article  CAS  PubMed  Google Scholar 

Wang JN, Wang F, Ke J, Li Z, Xu CH, Yang Q, Chen X, He XY, He Y, Suo XG, Li C, Yu JT, Jiang L, Ni WJ, Jin J, Liu MM, Shao W, Yang C, Gong Q, Chen HY, Meng XM (2022) Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms. Sci Transl Med 14(640):eabk2709. https://doi.org/10.1126/scitranslmed.abk2709

Article  CAS  PubMed  Google Scholar 

Xue JF, Shi ZM, Zou J, Li XL (2017) Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis. Biomed Pharmacother 89:1252–1261. https://doi.org/10.1016/j.biopha.2017.01.130

Article  CAS  PubMed  Google Scholar 

Yang C, Wang H, Zhao X, Matsushita K, Coresh J, Zhang L, Zhao MH (2020) CKD in China: evolving spectrum and public health implications. Am J Kidney Dis 76(2):258–264. https://doi.org/10.1053/j.ajkd.2019.05.032

Article  PubMed  Google Scholar 

Yang W, Xie L, Wang P, Zhuang C (2022) MiR-155 regulates m6A level and cell progression by targeting FTO in clear cell renal cell carcinoma. Cell Signal 91:110217. https://doi.org/10.1016/j.cellsig.2021.110217

Article  CAS  PubMed  Google Scholar 

Yang Y, Li Q, Ling Y, Leng L, Ma Y, Xue L, Lu G, Ding Y, Li J, Tao S (2023) m6A eraser FTO modulates autophagy by targeting SQSTM1/P62 in the prevention of canagliflozin against renal fibrosis. Front Immunol 13:1094556. https://doi.org/10.3389/fimmu.2022.1094556

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu JT, Hu XW, Chen HY, Yang Q, Li HD, Dong YH, Zhang Y, Wang JN, Jin J, Wu YG, Li J, Ge JF, Meng XM (2021) DNA methylation of FTO promotes renal inflammation by enhancing m6A of PPAR-α in alcohol-induced kidney injury. Pharmacol Res 163:105286. https://doi.org/10.1016/j.phrs.2020.105286

Article  CAS  PubMed  Google Scholar 

Yuan Y, Park J, Feng A, Awasthi P, Wang Z, Chen Q, Iglesias-Bartolome R (2020) YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity. Nat Commun 11(1):1472. https://doi.org/10.1038/s41467-020-15301-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang L, Long J, Jiang W, Shi Y, He X, Zhou Z, Li Y, Yeung RO, Wang J, Matsushita K, Coresh J, Zhao MH, Wang H (2016) Trends in chronic kidney disease in China. N Engl J Med 375(9):905–906. https://doi.org/10.1056/NEJMc1602469

Article  PubMed  Google Scholar 

Zhou Y, Hambly BD, McLachlan CS (2017) FTO associations with obesity and telomere length. J Biomed Sci 24(1):65. https://doi.org/10.1186/s12929-017-0372-6

Article  CAS  PubMed  PubMed Central  Google Scholar