Hassoun PM. Pulmonary arterial hypertension. N Engl J Med. 2021;385(25):2361–76.
Article CAS PubMed Google Scholar
Ruopp NF, Cockrill BA. Diagnosis and treatment of pulmonary arterial hypertension: a review. JAMA. 2022;327(14):1379–91.
Article CAS PubMed Google Scholar
Maron BA, Abman SH. Pulmonary arterial hypertension: diagnosis, treatment, and novel advances. Case Rep. 2021;203(12):1472–87.
Thenappan T, Ormiston ML, Ryan JJ, Archer SL. Pulmonary arterial hypertension: pathogenesis and clinical management. BMJ. 2018;360:j5492.
Article PubMed PubMed Central Google Scholar
Thompson AAR, Lawrie A. Targeting vascular remodeling to treat pulmonary arterial hypertension. Trends Mol Med. 2017;23(1):31–45.
Article CAS PubMed Google Scholar
Coons JC, Pogue K, Kolodziej AR, Hirsch GA, George MP. Pulmonary arterial hypertension: a pharmacotherapeutic update. Curr Cardiol Rep. 2019;21(11):141.
Ding DC, Shyu WC, Lin SZ. Mesenchymal stem cells. Cell Transplant. 2011;20(1):5–14.
Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol. 2008;8(9):726–36.
Article CAS PubMed Google Scholar
Ding DC, Chang YH, Shyu WC, Lin SZ. Human umbilical cord mesenchymal stem cells: a new era for stem cell therapy. Cell Transplant. 2015;24(3):339–47.
Li N, Hua J. Interactions between mesenchymal stem cells and the immune system. Cell Mol Life Sci. 2017;74(13):2345–60.
Article CAS PubMed Google Scholar
He J, Liu J, Huang Y, Tang X, Xiao H, Hu Z. Oxidative stress, inflammation, and autophagy: potential targets of mesenchymal stem cells-based therapies in ischemic stroke. Front Neurosci. 2021;15: 641157.
Article PubMed PubMed Central Google Scholar
Dierick F, Solinc J, Bignard J, Soubrier F, Nadaud S. Progenitor/stem cells in vascular remodeling during pulmonary arterial hypertension. Cells. 2021;10(6):1338.
Article CAS PubMed PubMed Central Google Scholar
Huang J, Lu W, Ouyang H, Chen Y, Zhang C, Luo X, Li M, Shu J, Zheng Q, Chen H, et al. Transplantation of mesenchymal stem cells attenuates pulmonary hypertension by normalizing the endothelial-to-mesenchymal transition. Am J Respir Cell Mol Biol. 2020;62(1):49–60.
Article CAS PubMed PubMed Central Google Scholar
Muhammad SA, Abbas AY, Saidu Y, Fakurazi S, Bilbis LS. Therapeutic efficacy of mesenchymal stromal cells and secretome in pulmonary arterial hypertension: a systematic review and meta-analysis. Biochimie. 2020;168:156–68.
Article CAS PubMed Google Scholar
Pan X, Suzuki N, Hirano I, Yamazaki S, Minegishi N, Yamamoto M. Isolation and characterization of renal erythropoietin-producing cells from genetically produced anemia mice. PLoS ONE. 2011;6(10):e25839.
Article CAS PubMed PubMed Central Google Scholar
Rathod DB, Salahudeen AK. Nonerythropoietic properties of erythropoietin: implication for tissue protection. J Investig Med. 2011;59(7):1083–5.
Article CAS PubMed Google Scholar
Sun LL, Lei FR, Jiang XD, Du XL, Xiao L, Li WD, Li XQ. LncRNA GUSBP5-AS promotes EPC migration and angiogenesis and deep vein thrombosis resolution by regulating FGF2 and MMP2/9 through the miR-223-3p/FOXO1/Akt pathway. Aging. 2020;12(5):4506–26.
Article CAS PubMed PubMed Central Google Scholar
Song Z, Lian W, He Y, Zhang C, Lin G. Targeting erythrocyte-mediated hypoxia to alleviate lung injury induced by pyrrolizidine alkaloids. Arch Toxicol. 2023;97(3):819–29.
Article CAS PubMed Google Scholar
Han XP, Zhang FQ, Tan XS, Liu L, Ma WX, Ou-Yang HF, Wu CG. EPO modified MSCs can inhibit asthmatic airway remodeling in an animal model. J Cell Biochem. 2018;119(1):1008–16.
Article CAS PubMed Google Scholar
Zhang Y, Zhou S, Hu JM, Chen H, Liu D, Li M, Guo Y, Fan LP, Li LY, Liu YG, et al. Preliminary study of bone marrow-derived mesenchymal stem cells pretreatment with erythropoietin in preventing acute rejection after rat renal transplantation. Transpl Proc. 2018;50(10):3873–80.
Sun C, Zhang S, Wang J, Jiang W, Xin Q, Chen X, Zhang Z, Luan Y. EPO enhances the protective effects of MSCs in experimental hyperoxia-induced neonatal mice by promoting angiogenesis. Aging. 2019;11(8):2477–87.
Article CAS PubMed PubMed Central Google Scholar
Cai C, Wu Y, Yang L, Xiang Y, Zhu N, Zhao H, Hu W, Lv L, Zeng C. Sodium selenite attenuates balloon injury-induced and monocrotaline-induced vascular remodeling in rats. Front Pharmacol. 2021;12: 618493.
Article CAS PubMed PubMed Central Google Scholar
Zhang ZH, Lu Y, Luan Y, Zhao JJ. Effect of bone marrow mesenchymal stem cells on experimental pulmonary arterial hypertension. Exp Ther Med. 2012;4(5):839–43.
Article PubMed PubMed Central Google Scholar
Luan Y, Zhang X, Kong F, Cheng GH, Qi TG, Zhang ZH. Mesenchymal stem cell prevention of vascular remodeling in high flow-induced pulmonary hypertension through a paracrine mechanism. Int Immunopharmacol. 2012;14(4):432–7.
Article CAS PubMed Google Scholar
Liu N, Tian J, Wang W, Cheng J, Hu D, Zhang J. Effect and mechanism of erythropoietin on mesenchymal stem cell proliferation in vitro under the acute kidney injury microenvironment. Exp Biol Med (Maywood). 2011;236(9):1093–9.
Article CAS PubMed Google Scholar
Tsiftsoglou AS. Erythropoietin (EPO) as a key regulator of erythropoiesis, bone remodeling and endothelial transdifferentiation of multipotent mesenchymal stem cells (mscs): implications in regenerative medicine. Cells. 2021;10(8):2140.
Article CAS PubMed PubMed Central Google Scholar
Yang ZH, Zhang SJ, Zhao HP, Li FF. Erythropoietin promotes the differentiation of fetal neural stem cells into glial cells via the erythropoietin receptor-β common receptor/Syne-1/H3K9me3 pathway. CNS Neurosci Ther. 2022;28(9):1351–64.
Article CAS PubMed PubMed Central Google Scholar
Allegra A, Galasso A, Siracusano L, Aloisi C, Corica F, Laganà A, Frisina N, Buemi M. Administration of recombinant erythropoietin determines increase of peripheral resistances in patients with hypovolemic shock. Nephron. 1996;74(2):431–2.
Article CAS PubMed Google Scholar
Allegra A, Giacobbe MS, Corvaia E, Cinquegrani M, Corvaja E, Giorgianni G, Buemi M. Possible role of erythropoietin in the pathogenesis of chronic cor pulmonale. Nephrol Dial Transplant. 2005;20(12):2866–7.
Article CAS PubMed Google Scholar
Satoh K, Kagaya Y, Nakano M, Ito Y, Ohta J, Tada H, Karibe A, Minegishi N, Suzuki N, Yamamoto M, et al. Important role of endogenous erythropoietin system in recruitment of endothelial progenitor cells in hypoxia-induced pulmonary hypertension in mice. Circulation. 2006;113(11):1442–50.
Article CAS PubMed Google Scholar
Hasegawa J, Wagner KF, Karp D, Li D, Shibata J, Heringlake M, Bahlmann L, Depping R, Fandrey J, Schmucker P, et al. Altered pulmonary vascular reactivity in mice with excessive erythrocytosis. Am J Respir Crit Care Med. 2004;169(7):829–35.
Weissmann N, Manz D, Buchspies D, Keller S, Mehling T, Voswinckel R, Quanz K, Ghofrani HA, Schermuly RT, Fink L, et al. Congenital erythropoietin over-expression causes “anti-pulmonary hypertensive” structural and functional changes in mice, both in normoxia and hypoxia. Thromb Haemost. 2005;94(3):630–8.
Tuder RM. Pulmonary vascular remodeling in pulmonary hypertension. Cell Tissue Res. 2017;367(3):643–9.
Leopold JA, Maron BA. Molecular mechanisms of pulmonary vascular remodeling in pulmonary arterial hypertension. Int J Mol Sci. 2016;17(5):761.
Article PubMed PubMed Central Google Scholar
Kovacs L, Cao Y, Han W, Meadows L, Kovacs-Kasa A, Kondrikov D, Verin AD, Barman SA, Dong Z, Huo Y, et al. PFKFB3 in smooth muscle promotes vascular remodeling in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2019;200(5):617–27.
Article CAS PubMed PubMed Central Google Scholar
Xie J, Hu D, Niu L, Qu S, Wang S, Liu S. Mesenchymal stem cells attenuate vascular remodeling in monocrotaline-induced pulmonary hypertension rats. J Huazhong Univ Scie Tehnol Medi Sci. 2012;32(6):810–7.
Comments (0)