Identification of novel loci for multiple myeloma when comparing with its precursor condition monoclonal gammopathy of unknown significance

Mouhieddine TH, Weeks LD, Ghobrial IM. Monoclonal gammopathy of undetermined significance. Blood. 2019;133:2484–94.

Article  CAS  PubMed  Google Scholar 

Landgren O, Kyle RA, Pfeiffer RM, Katzmann JA, Caporaso NE, Hayes RB, et al. Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study. Blood. 2009;113:5412–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rajkumar SV, Kyle RA, Therneau TM, Melton LJ 3rd, Bradwell AR, Clark RJ, et al. Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance. Blood. 2005;106:812–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Went M, Sud A, Forsti A, Halvarsson BM, Weinhold N, Kimber S, et al. Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma. Nat Commun. 2018;9:3707.

Article  PubMed  PubMed Central  Google Scholar 

Thomsen H, Chattopadhyay S, Weinhold N, Vodicka P, Vodickova L, Hoffmann P, et al. Genome-wide association study of monoclonal gammopathy of unknown significance (MGUS): comparison with multiple myeloma. Leukemia. 2019;33:1817–21.

Article  PubMed  Google Scholar 

Taliun D, Harris DN, Kessler MD, Carlson J, Szpiech ZA, Torres R, et al. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 2021;590:290–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Das S, Forer L, Schonherr S, Sidore C, Locke AE, Kwong A, et al. Next-generation genotype imputation service and methods. Nat Genet. 2016;48:1284–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McInerney TW, Fulton-Howard B, Patterson C, Paliwal D, Jermiin LS, Patel HR, et al. A globally diverse reference alignment and panel for imputation of mitochondrial DNA variants. BMC Bioinforma. 2021;22:417.

Article  CAS  Google Scholar 

Mitchell JS, Li N, Weinhold N, Forsti A, Ali M, van Duin M, et al. Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Nat Commun. 2016;7:12050.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, et al. A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFkappaB activity. Mol Cancer. 2009;8:97.

Article  PubMed  PubMed Central  Google Scholar 

Yang J, Zhang X, Cao J, Xu P, Chen Z, Wang S, et al. Circular RNA UBE2Q2 promotes malignant progression of gastric cancer by regulating signal transducer and activator of transcription 3-mediated autophagy and glycolysis. Cell Death Dis. 2021;12:910.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mo XT, Leung TH, Tang HW, Siu MK, Wan PK, Chan KK, et al. CD109 mediates tumorigenicity and cancer aggressiveness via regulation of EGFR and STAT3 signalling in cervical squamous cell carcinoma. Br J Cancer. 2020;123:833–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vyas S, Zaganjor E, Haigis MC. Mitochondria and cancer. Cell. 2016;166:555–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clay-Gilmour AI, Hildebrandt MAT, Brown EE, Hofmann JN, Spinelli JJ, Giles GG, et al. Coinherited genetics of multiple myeloma and its precursor, monoclonal gammopathy of undetermined significance. Blood Adv. 2020;4:2789–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Spira A, Yurgelun MB, Alexandrov L, Rao A, Bejar R, Polyak K, et al. Precancer atlas to drive precision prevention trials. Cancer Res. 2017;77:1510–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

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