Hodes-Wertz B, Grifo J, Ghadir S, Kaplan B, Laskin CA, Glassner M, et al. Idiopathic recurrent miscarriage is caused mostly by aneuploid embryos. Fertil Steril. 2012;98:675–80.

Article  PubMed  Google Scholar 

Marquard K, Westphal LM, Milki AA, Lathi RB. Etiology of recurrent pregnancy loss in women over the age of 35 years. Fertil Steril. 2010;94:1473–7.

Article  PubMed  Google Scholar 

Hassold T, Hunt P. To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet. 2001;2:280–91.

Article  CAS  PubMed  Google Scholar 

Pylyp LY, Spynenko LO, Verhoglyad NV, Mishenko AO, Mykytenko DO, Zukin VD. Chromosomal abnormalities in products of conception of first-trimester miscarriages detected by conventional cytogenetic analysis: a review of 1000 cases. J Assist Reprod Genet. 2018;35:265–71.

Article  PubMed  Google Scholar 

Lee H, McCulloh DH, Hodes-Wertz B, Adler A, McCaffrey C, Grifo JA. In vitro fertilization with preimplantation genetic screening improves implanation and live birth in women age 40 through 43. J Assist Reprod Genet. 2015;32:435–44.

Article  PubMed  PubMed Central  Google Scholar 

Franasiak JM, Forman EJ, Hong KH, Werner MD, Upham KM, Treff NR, et al. The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening. Fertil Steril. 2014;101:656–63.

Article  PubMed  Google Scholar 

Pantou A, Mitrakos A, Kokkali G, Petroutsou K, Tounta G, Lazaros L, Dimopoulos A, Sfakianoudis K, Pantos K, Koutsilieris M, Mavrou A, Kanavakis E, Tzetis M. The impact of preimplantation genetic testing for aneuploidies (PGT-A) on clinical outcomes in high risk patients. J Assist Reprod Genet. 2022;39:1341–9.

Article  PubMed  PubMed Central  Google Scholar 

Simopoulou M, Sfakianoudis K, Maziotis E, et al. PGT-A: who and when? Alpha systematic review and network meta-analysis of RCTs. J Assist Reprod Genet. 2021;38:1939–57.

Article  PubMed  PubMed Central  Google Scholar 

Roche K, Racowsky C, Harper J. Utilization of preimplantation genetic testing in the USA. J Assist Reprod Genet. 2021;38:1045–53.

Article  PubMed  PubMed Central  Google Scholar 

Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology. The use of preimplantation genetic testing for aneuploidy (PGT-A): a committee opinion. Fertil Steril. 2018;109(3):429–436.

Taylor TH, Patrick JL, Gitlin SA, Crain JL, Wilson JM, Griffin DK. Blastocyst euploidy and implantation rates in young (<35 years) and old (≥35 years) presumed fertile and infertile patient population. Fertil Steril. 2014;102:1318–23.

Article  PubMed  Google Scholar 

Kort JD, McCoy RC, Demko Z, Lathi RB. Are blastocyst aneuploidy rates different between fertile and infertile populations? J Assist Reprod Genet. 2018;35:403–8.

Article  PubMed  Google Scholar 

Hoyos LR, Cheng CY, Brennan K, et al. Euploid rates among oocyte donors: is there an optimal age for donation? J Assist Reprod Genet. 2020;37:589–94.

Article  PubMed  PubMed Central  Google Scholar 

Munne S, Alikani M, Ribustello L, et al. Euploidy rates in donor egg cycles significantly differ between fertility centers. Hum Reprod. 2017;32:743–9.

Article  CAS  PubMed  Google Scholar 

Leigh D, Cram DS, Rechitsky S, Handyside A, Wells D, Munne S, et al. PGDIS position statement on the transfer of mosaic embryos 2021. Reprod Biomed Online. 2022;45:19–25.

Article  CAS  PubMed  Google Scholar 

Practice Committee and Genetic Counseling Professional Group (GCPG) of the American Society for Reproductive Medicine. Clinical management of mosaic results from preimplantation genetic testing for aneuploidy (PGT-A) of blastocysts: a committee opinion. Fertil Steril. 2020;114:246–54.

Victor AR, Tyndall JC, Brake AJ, Lepkowsky LT, Murphy AE, Griffin DK, et al. One hundred mosaic embryos transferred prospectively in a single clinic: exploring when and why they result in healthy pregnancies. Fertil Steril. 2019;111:280–93.

Article  PubMed  Google Scholar 

Lee CI, Cheng EH, Lee MS, Lin PY, Chen YC, Chen CH, et al. Healthy live births from transfers of low-mosaicism embryos after preimplantation genetic testing for aneuploidy. J Assist Reprod Genet. 2020;37:2305–13.

Article  PubMed  PubMed Central  Google Scholar 

Fragouli E, Alfarawati S, Spath K, Babariya D, Tarozzi N, Borini A, et al. Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts. Hum Genet. 2017;136:805–19.

Article  CAS  PubMed  Google Scholar 

Zore T, Kroener LL, Wang C, Liu L, Buyalos R, Hubert G, Shamonki M. Transfer of embryos with segmental mosaicism is associated with a significant reduction in live-birth rate. Fertil Steril. 2019;111:69–76.

Article  PubMed  Google Scholar 

Capalbo A, Poli M, Rienzi L, Girardi L, Patassini C, Fabiani M, et al. Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial. Am J Hum Genet. 2021;108(12):2238–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stovezky YR, Romanski PA, Bortoletto P, Spandorfer SD. Body mass index is not associated with embryo ploidy in patients undergoing in vitro fertilization with preimplantation genetic testing. Fertil Steril. 2021;116:388–95.

Article  CAS  PubMed  Google Scholar 

Goldman KN, Hodes-Wertz B, McCulloh DH, Flom JD, Grifo JA. Association of body mass index with embryonic aneuploidy. Fertil Steril. 2015;103:744–8.

Article  PubMed  Google Scholar 

Massie JAM, Shahine LK, Milki A, Westphal L, Lathi R. Ovarian stimulation and the risk of aneuploid conceptions. Fertil Steril. 2011;95:970–2.

Article  PubMed  Google Scholar 

Barash OO, Hinckley MD, Rosenbluth EM, Ivani KA, Weckstein LN. Hum Reprod. 2017;32:2209–17.

Article  CAS  PubMed  Google Scholar 

Cascales A, Lledó B, Ortiz JA, Morales R, Ten J, Llácer J, et al. Effect of ovarian stimulation on embryo aneuploidy and mosaicism rate. Syst Biol Reprod Med. 2021;67:42–9.

Article  CAS  PubMed  Google Scholar 

Baart EB, Martini E, Eijkemans MJ, van Opstal D, Beckers NGM, Verhoeff A, et al. Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial. Hum Reprod. 2007;22:980–8.

Article  PubMed  Google Scholar 

Katz-Jaffe MG, Trounson AO, Cram DS. Chromosome 21 mosaic human preimplantation embryos predominantly arise from diploid conceptions. Fertil Steril. 2005;84:634–43.

Article  PubMed  Google Scholar