MiR-150-5p contributes to unexplained recurrent spontaneous abortion by targeting VEGFA and downregulating the PI3K/AKT/mTOR signaling pathway

Zhao W, Shen WW, Cao XM, Ding WY, Yan LP, Gao LJ, Li XL, Zhong TY. Novel mechanism of miRNA-365-regulated trophoblast apoptosis in recurrent miscarriage. J Cell Mol Med. 2017;21:2412–25. https://doi.org/10.1111/jcmm.13163.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rai R, Regan L. Recurrent miscarriage. Lancet. 2006;368:601–11. https://doi.org/10.1016/S0140-6736(06)69204-0.

Article  PubMed  Google Scholar 

Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M. Maternal age and fetal loss: population based register linkage study. BMJ. 2000;320:1708–12. https://doi.org/10.1136/bmj.320.7251.1708.

Article  CAS  PubMed  Google Scholar 

Liu Y, Liu Y, Zhang S, Chen H, Liu M, Zhang J. Etiology of spontaneous abortion before and after the demonstration of embryonic cardiac activity in women with recurrent spontaneous abortion. Int J Gynaecol Obstet. 2015;129:128–32. https://doi.org/10.1016/j.ijgo.2014.11.012.

Article  PubMed  Google Scholar 

Laird SM, Tuckerman EM, Cork BA, Linjawi S, Blakemore AI, Li TC. A review of immune cells and molecules in women with recurrent miscarriage. Hum Reprod Update. 2003;9:163–74. https://doi.org/10.1093/humupd/dmg013.

Article  CAS  PubMed  Google Scholar 

Lee YS, Dutta A. MicroRNAs in cancer. Annu Rev Pathol. 2009;4:199–227. https://doi.org/10.1146/annurev.pathol.4.110807.092222.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116:281–97. https://doi.org/10.1016/s0092-8674(04)00045-5.

Article  CAS  PubMed  Google Scholar 

Zhang C. MicroRNomics: a newly emerging approach for disease biology. Physiol Genom. 2008;33:139–47. https://doi.org/10.1152/physiolgenomics.00034.2008.

Article  CAS  Google Scholar 

Urbich C, Kuehbacher A, Dimmeler S. Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res. 2008;79:581–8. https://doi.org/10.1093/cvr/cvn156.

Article  CAS  PubMed  Google Scholar 

Zhu Q, Dong YC, Zhang L, Ma X, Xia HF. miR-98 is involved in missed abortion by targeting GDF6 and FAPP2. Reproduction. 2020;159:525–37. https://doi.org/10.1530/REP-19-0282.

Article  CAS  PubMed  Google Scholar 

Zhang CY, Lu XL, Yang Y, Ayi N, Li LH. Highly expressed microRNA-940 promotes early abortion by regulating placenta implantation by targeting ZNF672. Eur Rev Med Pharmacol Sci. 2019;23:2693–700. https://doi.org/10.26355/eurrev_201904_17539.

Article  PubMed  Google Scholar 

Zhang Y, Zhou J, Li MQ, Xu J, Zhang JP, Jin LP. MicroRNA-184 promotes apoptosis of trophoblast cells via targeting WIG1 and induces early spontaneous abortion. Cell Death Dis. 2019;10:223. https://doi.org/10.1038/s41419-019-1443-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo L, Yao L, Xie Y, Chen E, Ding Y, Ge L. miR-526b-5p/c-Myc/Foxp1 participates in recurrent spontaneous abortion by regulating the proliferation, migration, and invasion of trophoblasts. J Assist Reprod Genet. 2023;40:1559–72. https://doi.org/10.1007/s10815-023-02793-0.

Article  PubMed  Google Scholar 

Moser G, Weiss G, Sundl M, Gauster M, Siwetz M, Lang-Olip I, Huppertz B. Extravillous trophoblasts invade more than uterine arteries: evidence for the invasion of uterine veins. Histochem Cell Biol. 2017;147:353–66. https://doi.org/10.1007/s00418-016-1509-5.

Article  CAS  PubMed  Google Scholar 

Zong S, Li C, Luo C, Zhao X, Liu C, Wang K, Jia W, Bai M, Yin M, Bao S, Guo J, Kang J, Duan T, Zhou Q. Dysregulated expression of IDO may cause unexplained recurrent spontaneous abortion through suppression of trophoblast cell proliferation and migration. Sci Rep. 2016;6:19916. https://doi.org/10.1038/srep19916.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li L, Tian J, Zhou L, Wu S, Zhang S, Qi L, Zhang H. Role of kisspeptin/GPR54 in the first trimester trophoblast of women with a history of recurrent spontaneous abortion. Int J Clin Exp Pathol. 2017;10:8161–73.

PubMed  PubMed Central  Google Scholar 

Liu X, Zhao J, Luan X, Li S, Zhai J, Liu J, Du Y. SPARCL1 impedes trophoblast migration and invasion by down-regulating ERK phosphorylation and AP-1 production and altering EMT-related molecule expression. Placenta. 2020;89:33–41. https://doi.org/10.1016/j.placenta.2019.10.007.

Article  CAS  PubMed  Google Scholar 

Zhao J, Zhang ZR, Zhao N, Ma BA, Fan QY. VEGF silencing inhibits human osteosarcoma angiogenesis and promotes cell apoptosis via PI3K/AKT signaling pathway. Int J Clin Exp Med. 2015;8:12411–7.

CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Lu YH, Tang C, Xue M, Li XY, Chang YP, Cheng Y, Li T, Yu XC, Sun B, Li CJ, Chen LM. Calcium dobesilate restores autophagy by inhibiting the VEGF/PI3K/AKT/mTOR signaling pathway. Front Pharmacol. 2019;10:886. https://doi.org/10.3389/fphar.2019.00886.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ortega MA, Fraile-Martinez O, Asunsolo A, Bujan J, Garcia-Honduvilla N, Coca S. Signal transduction pathways in breast cancer: the important role of PI3K/Akt/mTOR. J Oncol. 2020;2020:9258396. https://doi.org/10.1155/2020/9258396.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Massari F, Ciccarese C, Santoni M, Brunelli M, Piva F, Modena A, Bimbatti D, Fantinel E, Santini D, Cheng L, Cascinu S, Montironi R, Tortora G. Metabolic alterations in renal cell carcinoma. Cancer Treat Rev. 2015;41:767–76. https://doi.org/10.1016/j.ctrv.2015.07.002.

Article  CAS  PubMed  Google Scholar 

Qin W, Tang Y, Yang N, Wei X, Wu J. Potential role of circulating microRNAs as a biomarker for unexplained recurrent spontaneous abortion. Fertil Steril. 2016;105:1247-1254 e3. https://doi.org/10.1016/j.fertnstert.2016.01.028.

Article  CAS  PubMed  Google Scholar 

Liu HN, Tang XM, Wang XQ, Gao J, Li N, Wang YY, Xia HF. MiR-93 inhibits trophoblast cell proliferation and promotes cell apoptosis by targeting BCL2L2 in recurrent spontaneous abortion. Reprod Sci. 2020;27:152–62. https://doi.org/10.1007/s43032-019-00003-w.

Article  CAS  PubMed  Google Scholar 

Zhu Y, Lu H, Huo Z, Ma Z, Dang J, Dang W, Pan L, Chen J, Zhong H. MicroRNA-16 inhibits feto-maternal angiogenesis and causes recurrent spontaneous abortion by targeting vascular endothelial growth factor. Sci Rep. 2016;6:35536. https://doi.org/10.1038/srep35536.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferracin M, Veronese A, Negrini M. Micromarkers: miRNAs in cancer diagnosis and prognosis. Expert Rev Mol Diagn. 2010;10:297–308. https://doi.org/10.1586/erm.10.11.

Article  CAS  PubMed  Google Scholar 

Luu HN, Lin HY, Sorensen KD, Ogunwobi OO, Kumar N, Chornokur G, Phelan C, Jones D, Kidd L, Batra J, Yamoah K, Berglund A, Rounbehler RJ, Yang M, Lee SH, Kang N, Kim SJ, Park JY, Di Pietro G. miRNAs associated with prostate cancer risk and progression. BMC Urol. 2017;17:18. https://doi.org/10.1186/s12894-017-0206-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136:215–33. https://doi.org/10.1016/j.cell.2009.01.002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu W, Zhang H, Niu Y, Wu Y, Sun W, Li H, Kong J, Ding K, Shen HM, Wu H, Xia D, Wu Y. Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p. Mol Cancer. 2017;16:118. https://doi.org/10.1186/s12943-017-0685-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao YJ, Song X, Niu L, Tang Y, Song X, Xie L. Circulating exosomal miR-150-5p and miR-99b-5p as diagnostic biomarkers for colorectal cancer. Front Oncol. 2019;9:1129. https://doi.org/10.3389/fonc.2019.01129.

Article  PubMed  PubMed Central  Google Scholar 

Leoncini PP, Bertaina A, Papaioannou D, Flotho C, Masetti R, Bresolin S, Menna G, Santoro N, Zecca M, Basso G, Nigita G, Veneziano D, Pagotto S, D’Ovidio K, Rota R, Dorrance A, Croce CM, Niemeyer C, Locatelli F, Garzon R. MicroRNA fingerprints in juvenile myelomonocytic leukemia (JMML) identified miR-150-5p as a tumor suppressor and potential target for treatment. Oncotarget. 2016;7:55395–408. https://doi.org/10.18632/oncotarget.10577.

Article  PubMed  PubMed Central  Google Scholar 

Wang WH, Chen J, Zhao F, Zhang BR, Yu HS, Jin HY, Dai JH. MiR-150-5p suppresses colorectal cancer cell migration and invasion through targeting MUC4. Asian Pac J Cancer Prev. 2014;15:6269–73. https://doi.org/10.7314/apjcp.2014.15.15.6269.

Article  PubMed  Google Scholar 

Liang L, Zhang Z, Qin X, Gao Y, Zhao P, Liu J, Zeng W. Long noncoding RNA ZFAS1 promotes tumorigenesis through regulation of miR-150-5p/RAB9A in melanoma. Melanoma Res. 2019;29:569–81. https://doi.org/10.1097/CMR.0000000000000595.

Article  CAS 

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