Biomarkers Assessing the Role of Cumulus Cells on IVF Outcomes: A Systematic Review

Ozturk S. Selection of competent oocytes by morphological criteria for assisted reproductive technologies. Mol Reprod Dev. 2020;87(10):1021–36. https://doi.org/10.1002/mrd.23420.

Article  CAS  PubMed  Google Scholar 

Gardner DK, Balaban B. Assessment of human embryo development using morphological criteria in an era of time-lapse, algorithms and ‘OMICS’: is looking good still important? Mol Hum Reprod. 2016;22(10):704–18. https://doi.org/10.1093/molehr/gaw057.

Article  PubMed  Google Scholar 

Turathum B, Gao EM, Chian RC. The function of cumulus cells in oocyte growth and maturation and in subsequent ovulation and fertilization. Cells. 2021;10(9) https://doi.org/10.3390/cells10092292.

Sirait B, et al. Oocyte competence biomarkers associated with oocyte maturation: a review. Front Cell Dev Biol. 2021;9:710292. https://doi.org/10.3389/fcell.2021.710292.

Article  PubMed  PubMed Central  Google Scholar 

Moher D, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535. https://doi.org/10.1136/bmj.b2535.

Article  PubMed  PubMed Central  Google Scholar 

Alfaidy N, et al. Prokineticin 1 is a new biomarker of human oocyte competence: expression and hormonal regulation throughout late folliculogenesis. Biol Reprod. 2019;101(4):832–41. https://doi.org/10.1093/biolre/ioz114.

Article  PubMed  Google Scholar 

Anderson RA, et al. Cumulus gene expression as a predictor of human oocyte fertilisation, embryo development and competence to establish a pregnancy. Reproduction. 2009;138(4):629–37. https://doi.org/10.1530/REP-09-0144.

Article  CAS  PubMed  Google Scholar 

Assidi M, et al. Biomarkers of human oocyte developmental competence expressed in cumulus cells before ICSI: a preliminary study. J Assist Reprod Genet. 2011;28(2):173–88. https://doi.org/10.1007/s10815-010-9491-7.

Article  PubMed  Google Scholar 

Assou S, et al. A non-invasive test for assessing embryo potential by gene expression profiles of human cumulus cells: a proof of concept study. Mol Hum Reprod. 2008;14(12):711–9. https://doi.org/10.1093/molehr/gan067.

Article  CAS  PubMed  Google Scholar 

Baratas A, et al. Cumulus cell DNA damage as an index of human oocyte competence. Reprod Sci. 2022;29(11):3194–200. https://doi.org/10.1007/s43032-021-00817-7.

Article  CAS  PubMed  Google Scholar 

Bartolucci AF, Uliasz T, Peluso JJ. MicroRNA-21 as a regulator of human cumulus cell viability and its potential influence on the developmental potential of the oocyte. Biol Reprod. 2020;103(1):94–103. https://doi.org/10.1093/biolre/ioaa058.

Article  PubMed  Google Scholar 

Bosco L, et al. Relationship between apoptosis and survival molecules in human cumulus cells as markers of oocyte competence. Zygote. 2017;25(5):583–91. https://doi.org/10.1017/S0967199417000429.

Article  CAS  PubMed  Google Scholar 

Cheng EH, et al. Evaluation of telomere length in cumulus cells as a potential biomarker of oocyte and embryo quality. Hum Reprod. 2013;28(4):929–36. https://doi.org/10.1093/humrep/det004.

Article  CAS  PubMed  Google Scholar 

Cillo F, et al. Association between human oocyte developmental competence and expression levels of some cumulus genes. Reproduction. 2007;134(5):645–50. https://doi.org/10.1530/REP-07-0182.

Article  CAS  PubMed  Google Scholar 

Daei-Farshbaf N, et al. Expression pattern of olfactory receptor genes in human cumulus cells as an indicator for competent oocyte selection. Turk J Biol. 2020;44(6):371–80. https://doi.org/10.3906/biy-2003-79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Daei-Farshbaf N, et al. Identification of calcineurin as a predictor of oocyte quality and fertilization competence based on microarray data. Comput Biol Chem. 2021;94:107561. https://doi.org/10.1016/j.compbiolchem.2021.107561.

Article  CAS  PubMed  Google Scholar 

Demiray SB, et al. Expression of the bone morphogenetic protein-2 (BMP2) in the human cumulus cells as a biomarker of oocytes and embryo quality. J Hum Reprod Sci. 2017;10(3):194–200. https://doi.org/10.4103/jhrs.JHRS_21_17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Desquiret-Dumas V, et al. The mitochondrial DNA content of cumulus granulosa cells is linked to embryo quality. Hum Reprod. 2017;32(3):607–14. https://doi.org/10.1093/humrep/dew341.

Article  CAS  PubMed  Google Scholar 

Devjak R, et al. Embryo quality predictive models based on cumulus cells gene expression. Balkan J Med Genet. 2016;19(1):5–12. https://doi.org/10.1515/bjmg-2016-0001.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ekart J, et al. Ranking and selection of MII oocytes in human ICSI cycles using gene expression levels from associated cumulus cells. Hum Reprod. 2013;28(11):2930–42. https://doi.org/10.1093/humrep/det357.

Article  CAS  PubMed  Google Scholar 

Fang Y, et al. Cited2 protein level in cumulus cells is a biomarker for human embryo quality and pregnancy outcome in one in vitro fertilization cycle. Fertil Steril. 2016;105(5):1351-1359 e4. https://doi.org/10.1016/j.fertnstert.2015.12.137.

Article  CAS  PubMed  Google Scholar 

Feuerstein P, et al. Genomic assessment of human cumulus cell marker genes as predictors of oocyte developmental competence: impact of various experimental factors. PLoS One. 2012;7(7):e40449. https://doi.org/10.1371/journal.pone.0040449.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gebhardt KM, et al. Human cumulus cell gene expression as a biomarker of pregnancy outcome after single embryo transfer. Fertil Steril. 2011;96(1):47-52 e2. https://doi.org/10.1016/j.fertnstert.2011.04.033.

Article  CAS  PubMed  Google Scholar 

Hammond ER, et al. Assessing embryo quality by combining non-invasive markers: early time-lapse parameters reflect gene expression in associated cumulus cells. Hum Reprod. 2015;30(8):1850–60. https://doi.org/10.1093/humrep/dev121.

Article  CAS  PubMed  Google Scholar 

Hasegawa J, et al. Reduction of progesterone receptor expression in human cumulus cells at the time of oocyte collection during IVF is associated with good embryo quality. Hum Reprod. 2005;20(8):2194–200. https://doi.org/10.1093/humrep/dei005.

Article  CAS  PubMed  Google Scholar 

Ito M, et al. Glutathione S-transferase theta 1 expressed in granulosa cells as a biomarker for oocyte quality in age-related infertility. Fertil Steril. 2008;90(4):1026–35. https://doi.org/10.1016/j.fertnstert.2007.07.1389.

Article  CAS  PubMed  Google Scholar 

Kim MJ, et al. Upregulation of low-density lipoprotein receptor of the steroidogenesis pathway in the cumulus cells is associated with the maturation of oocytes and achievement of pregnancy. Cells. 2021;10(9) https://doi.org/10.3390/cells10092389.

Kordus RJ, et al. Cumulus cell pappalysin-1, luteinizing hormone/choriogonadotropin receptor, amphiregulin and hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 mRNA levels associate with oocyte developmental competence and embryo outcomes. J Assist Reprod Genet. 2019;36(7):1457–69. https://doi.org/10.1007/s10815-019-01489-8.

Article  PubMed  PubMed Central  Google Scholar 

Lee MS, et al. Association of creatin kinase B and peroxiredoxin 2 expression with age and embryo quality in cumulus cells. J Assist Reprod Genet. 2010;27(11):629–39. https://doi.org/10.1007/s10815-010-9459-7.

Article  PubMed  PubMed Central  Google Scholar 

Li Y, et al. Increased GDF9 and BMP15 mRNA levels in cumulus granulosa cells correlate with oocyte maturation, fertilization, and embryo quality in humans. Reprod Biol Endocrinol. 2014;12:81. https://doi.org/10.1186/1477-7827-12-81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li SH, et al. Correlation of cumulus gene expression of GJA1, PRSS35, PTX3, and SERPINE2 with oocyte maturation, fertilization, and embryo development. Reprod Biol Endocrinol. 2015;13:93. https://doi.org/10.1186/s12958-015-0091-3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matos L, et al. Superoxide dismutase expression in human cumulus oophorus cells. Mol Hum Reprod. 2009;15(7):411–9. https://doi.org/10.1093/molehr/gap034.

Article  CAS  PubMed  Google Scholar 

McKenzie LJ, et al. Human cumulus granulosa cell gene expression: a predictor of fertilization and embryo selection in women undergoing IVF. Hum Reprod. 2004;19(12):2869–74. https://doi.org/10.1093/humrep/deh535.

Article  CAS  PubMed  Google Scholar 

Montazeri F, et al. Association between cumulus cells—mRNA levels of AMHR2 and FSHR with oocyte maturity. Middle East Fertil Soc J. 2022;27(1):26. https://doi.org/10.1186/s43043-022-00116-4.

Article  Google Scholar 

Papamentzelopoulou M, et al. LH receptor gene expression in cumulus cells in women entering an ART program. J Assist Reprod Genet. 2012;29(5):409–16. https://doi.org/10.1007/s10815-012-9729-7.

Article  PubMed  PubMed Central 

Comments (0)

No login
gif