Renaissance in sperm cytoplasmic contribution to infertility

Swann K. Sperm factors and egg activation: PLCzeta as the sperm factor that activates eggs: 20 years on. Reproduction. 2022;164:E1–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Avidor-Reiss T, Uzbekov R. Revisiting the mystery of centrioles at the beginning of mammalian embryogenesis. J Assist Reprod Genet. 2023. https://doi.org/10.1007/s10815-023-02927-4.

Liu J, Hermo L, Ding D, Wei C, Mann JM, Yan X, Melnick AF, Wu Y, Withrow A, Cibelli J, Hess RA, Chen C. SYPL1 defines a vesicular pathway essential for sperm cytoplasmic droplet formation and male fertility. Nat Commun. 2023;14:5113.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leung MR, Zeng J, Wang X, Roelofs MC, Huang W, Zenezini Chiozzi R, Hevler JF, Heck AJR, Dutcher SK, Brown A, Zhang R, Zeev-Ben-Mordehai T. Structural specializations of the sperm tail. Cell. 2023;186(2880-2896):e2817.

Google Scholar 

Zhou L, Liu H, Liu S, Yang X, Dong Y, Pan Y, Xiao Z, Zheng B, Sun Y, Huang P, Zhang X, Hu J, Sun R, Feng S, Zhu Y, Liu M, Gui M, Wu J. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Cell. 2023;186(2897-2910):e2819.

Google Scholar 

Cooper TG. The epididymis, cytoplasmic droplets and male fertility. Asian J Androl. 2011;13:130–8.

Article  PubMed  Google Scholar 

Cooper TG, Yeung CH, Fetic S, Sobhani A, Nieschlag E. Cytoplasmic droplets are normal structures of human sperm but are not well preserved by routine procedures for assessing sperm morphology. Hum Reprod. 2004;19:2283–8.

Article  PubMed  Google Scholar 

Čipak A, Stanić P, Đurić K, Serdar T, Suchanek E. Sperm morphology assessment according to WHO and strict criteria: method comparison and intra-laboratory variability. Biochemia Medica. 2009;19:87–94.

Article  Google Scholar 

Bloom G, Nicander L. On the ultrastructure and development of the protoplasmic droplet of spermatozoa. Z Zellforsch Mikrosk Anat. 1961;55:833–44.

Article  Google Scholar 

Liu L, He Q, Li Y, Zhang B, Sun X, Shan J, Pan B, Zhang T, Zhao Z, Song X, Guo Y. Serum SYPL1 is a promising diagnostic biomarker for colorectal cancer. Clin Chim Acta. 2020;509:36–42.

Article  CAS  PubMed  Google Scholar 

Yeung CH, Wagenfeld A, Nieschlag E, Cooper TG. The cause of infertility of male c-ros tyrosine kinase receptor knockout mice. Biol Reprod. 2000;63:612–8.

Article  CAS  PubMed  Google Scholar 

Pandruvada S, Royfman R, Shah TA, Sindhwani P, Dupree JM, Schon S, Avidor-Reiss T. Lack of trusted diagnostic tools for undetermined male infertility. J Assist Reprod Genet. 2021;38:265–76.

Article  PubMed  PubMed Central  Google Scholar 

Gipson JD, Bornstein MJ, Hindin MJ. Infertility: a continually neglected component of sexual and reproductive health and rights. Bull World Health Organ. 2020;98:505–6.

Article  PubMed  PubMed Central  Google Scholar 

Barratt CLR, De Jonge CJ, Sharpe RM. ‘Man Up’: the importance and strategy for placing male reproductive health centre stage in the political and research agenda. Human reproduction (Oxford, England). 2018;33:541–5.

Article  PubMed  Google Scholar 

Mehta A, Nangia AK, Dupree JM, Smith JF. Limitations and barriers in access to care for male factor infertility. Fertil Steril. 2016;105:1128–37.

Article  PubMed  Google Scholar 

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