Infection with Carbapenem-resistant Hypervirulent Klebsiella Pneumoniae: clinical, virulence and molecular epidemiological characteristics

Paczosa MK, Mecsas J. Klebsiella pneumoniae: going on the offense with a strong defense. Microbiol Mol Biology Reviews: MMBR. 2016;80(3):629–61. PubMed PMID: 27307579. Pubmed Central PMCID: PMC4981674. Epub 2016/06/17. eng.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bialek-Davenet S, Criscuolo A, Ailloud F, Passet V, Jones L, Delannoy-Vieillard AS, et al. Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups. Emerg Infect Dis. 2014;20(11):1812–20. PubMed PMID: 25341126. Pubmed Central PMCID: PMC4214299. Epub 2014/10/24. eng.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin YC, Lu MC, Tang HL, Liu HC, Chen CH, Liu KS, et al. Assessment of hypermucoviscosity as a virulence factor for experimental Klebsiella pneumoniae Infections: comparative virulence analysis with hypermucoviscosity-negative strain. BMC Microbiol. 2011;11:50. PubMed PMID: 21385400. Pubmed Central PMCID: PMC3060850. Epub 2011/03/10. eng.

Article  PubMed  PubMed Central  Google Scholar 

Zhang Y, Zeng J, Liu W, Zhao F, Hu Z, Zhao C, et al. Emergence of a hypervirulent carbapenem-resistant Klebsiella pneumoniae isolate from clinical Infections in China. J Infect. 2015;71(5):553–60. PubMed PMID: 26304687. Epub 2015/08/26. eng.

Article  PubMed  Google Scholar 

Russo TA, Olson R, Fang CT, Stoesser N, Miller M, MacDonald U et al. Identification of biomarkers for differentiation of Hypervirulent Klebsiella pneumoniae from classical K. pneumoniae. J Clin Microbiol. 2018;56(9). PubMed PMID: 29925642. Pubmed Central PMCID: PMC6113484. Epub 2018/06/22. eng.

Gu D, Dong N, Zheng Z, Lin D, Huang M, Wang L, et al. A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Lancet Infect Dis. 2018;18(1):37–46. PubMed PMID: 28864030. Epub 2017/09/03. eng.

Article  PubMed  Google Scholar 

Zhang R, Lin D, Chan EW, Gu D, Chen GX, Chen S. Emergence of Carbapenem-resistant serotype K1 hypervirulent Klebsiella pneumoniae strains in China. Antimicrob Agents Chemother. 2016;60(1):709–11. PubMed PMID: 26574010. Pubmed Central PMCID: PMC4704206. Epub 2015/11/18. eng.

Article  CAS  PubMed  Google Scholar 

Bulger J, MacDonald U, Olson R, Beanan J, Russo TA. Metabolite Transporter PEG344 is required for full virulence of Hypervirulent Klebsiella pneumoniae strain hvKP1 after pulmonary but not subcutaneous challenge. Infect Immun. 2017;85(10). PubMed PMID: 28717029. Pubmed Central PMCID: PMC5607406. Epub 2017/07/19. eng.

Holt KE, Wertheim H, Zadoks RN, Baker S, Whitehouse CA, Dance D, et al. Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health. Proc Natl Acad Sci USA. 2015;112(27):E3574–81. PubMed PMID: 26100894. Pubmed Central PMCID: PMC4500264. Epub 2015/06/24. eng.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu BT, Su WQ. Whole genome sequencing of NDM-1-producing serotype K1 ST23 hypervirulent Klebsiella pneumoniae in China. J Med Microbiol. 2019;68(6):866–73. PubMed PMID: 31107201. Epub 2019/05/21. eng.

Article  CAS  PubMed  Google Scholar 

Xie M, Yang X, Xu Q, Ye L, Chen K, Zheng Z, et al. Clinical evolution of ST11 carbapenem resistant and hypervirulent Klebsiella pneumoniae. Commun Biology. 2021;4(1):650. PubMed PMID: 34075192. Pubmed Central PMCID: PMC8169677. Epub 2021/06/03. eng.

Article  CAS  Google Scholar 

Liu C, Du P, Xiao N, Ji F, Russo TA, Guo J. Hypervirulent Klebsiella pneumoniae is emerging as an increasingly prevalent K. pneumoniae pathotype responsible for nosocomial and healthcare-associated Infections in Beijing, China. Virulence. 2020;11(1):1215–24. PubMed PMID: 32921250. Pubmed Central PMCID: PMC7549996. Epub 2020/09/15. eng.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang X, Sun Q, Li J, Jiang Y, Li Y, Lin J, et al. Molecular epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae in China. Emerg Microbes Infections. 2022;11(1):841–9. PubMed PMID: 35236251. Pubmed Central PMCID: PMC8942559. Epub 2022/03/04. eng.

Article  CAS  Google Scholar 

Liu XW, Li DZ, Hu Y, Zhu R, Liu DM, Guo MY et al. [Molecular epidemiological characterization of hypervirulent carbapenem-resistant Klebsiella pneumoniae in a hospital in Henan Province from 2020 to 2022]. Zhonghua Yu Fang Yi Xue Za Zhi [Chinese journal of preventive medicine]. 2023;57(8):1222–30. PubMed PMID: 37574316. Epub 2023/08/14. chi.

Lan P, Jiang Y, Zhou J, Yu Y. A global perspective on the convergence of hypervirulence and carbapenem resistance in Klebsiella pneumoniae. J Global Antimicrob Resist. 2021;25:26–34. PubMed PMID: 33667703. Epub 2021/03/06. eng.

Article  CAS  Google Scholar 

Spadar A, Perdigão J, Campino S, Clark TG. Large-scale genomic analysis of global Klebsiella pneumoniae plasmids reveals multiple simultaneous clusters of carbapenem-resistant hypervirulent strains. Genome Med. 2023;15(1):3. PubMed PMID: 36658655. Pubmed Central PMCID: PMC9850321. Epub 2023/01/20. eng.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shon AS, Bajwa RP, Russo TA. Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence. 2013;4(2):107–18. PubMed PMID: 23302790. Pubmed Central PMCID: PMC3654609. Epub 2013/01/11. eng.

Article  PubMed  PubMed Central  Google Scholar 

Li G, Shi J, Zhao Y, Xie Y, Tang Y, Jiang X et al. Identification of hypervirulent Klebsiella pneumoniae isolates using the string test in combination with Galleria mellonella infectivity. European journal of clinical microbiology & infectious Diseases: official publication of the European Society of Clinical Microbiology. 2020;39(9):1673–9. PubMed PMID: 32318968. Epub 2020/04/23. eng.

Chen YT, Chang HY, Lai YC, Pan CC, Tsai SF, Peng HL. Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43. Gene. 2004;337:189 – 98. PubMed PMID: 15276215. Epub 2004/07/28. eng.

Wu KM, Li LH, Yan JJ, Tsao N, Liao TL, Tsai HC, et al. Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and Meningitis. J Bacteriol. 2009;191(14):4492–501. PubMed PMID: 19447910. Pubmed Central PMCID: PMC2704730. Epub 2009/05/19. eng.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Y, Zhang X, Torres VVL, Liu H, Rocker A, Zhang Y, et al. An outbreak of Carbapenem-resistant and hypervirulent Klebsiella pneumoniae in an Intensive Care Unit of a major Teaching Hospital in Wenzhou, China. Front Public Health. 2019;7:229. PubMed PMID: 31552210. Pubmed Central PMCID: PMC6736603. Epub 2019/09/26. eng.

Article  PubMed  PubMed Central  Google Scholar 

Zhang Y, Jin L, Ouyang P, Wang Q, Wang R, Wang J, et al. Evolution of hypervirulence in carbapenem-resistant Klebsiella pneumoniae in China: a multicentre, molecular epidemiological analysis. J Antimicrob Chemother. 2020;75(2):327–36. PubMed PMID: 31713615. Epub 2019/11/13. eng.

Article  CAS  PubMed  Google Scholar 

Tang N, Li Y, Yao S, Hu J, Zhao Y, Fu S, et al. Epidemicity and clonal replacement of hypervirulent carbapenem-resistant Klebsiella pneumoniae with diverse pathotypes and resistance profiles in a hospital. J Global Antimicrob Resist. 2023;32:4–10. PubMed PMID: 36400407. Epub 2022/11/19. eng.

Article  CAS  Google Scholar 

Tian D, Liu X, Chen W, Zhou Y, Hu D, Wang W, et al. Prevalence of hypervirulent and carbapenem-resistant Klebsiella pneumoniae under divergent evolutionary patterns. Emerg Microbes Infections. 2022;11(1):1936–49. PubMed PMID: 35844192. Pubmed Central PMCID: PMC9359173. Epub 2022/07/19. eng.

Article  CAS  Google Scholar 

Liu YC, Cheng DL, Lin CL. Klebsiella pneumoniae liver abscess associated with septic endophthalmitis. Arch Intern Med. 1986;146(10):1913–6. PubMed PMID: 3532983. Epub 1986/10/01. eng.

Article  CAS  PubMed  Google Scholar 

Rossi B, Gasperini ML, Leflon-Guibout V, Gioanni A, de Lastours V, Rossi G et al. Hypervirulent Klebsiella pneumoniae in Cryptogenic Liver Abscesses, Paris, France. Emerging infectious Diseases. 2018;24(2):221–9. PubMed PMID: 29350134. Pubmed Central PMCID: PMC5782876. Epub 2018/01/20. eng.

Wei T, Zou C, Qin J, Tao J, Yan L, Wang J, et al. Emergence of Hypervirulent ST11-K64 Klebsiella pneumoniae poses a serious clinical threat in older patients. Front Public Health. 2022;10:765624. PubMed PMID: 35309213. Pubmed Central PMCID: PMC8930914. Epub 2022/03/22. eng.

Article  PubMed  PubMed Central  Google Scholar 

Han R, Shi Q, Wu S, Yin D, Peng M, Dong D, et al. Dissemination of Carbapenemases (KPC, NDM, OXA-48, IMP, and VIM) among carbapenem-resistant Enterobacteriaceae isolated from adult and children patients in China. Front Cell Infect Microbiol. 2020;10:314. PubMed PMID: 32719751. Pubmed Central PMCID: PMC7347961. Epub 2020/07/29. eng.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Suay-García B, Pérez-Gracia MT. Present and Future of Carbapenem-resistant Enterobacteriaceae (CRE) Infections. Antibiotics (Basel, Switzerland). 2019;8(3). PubMed PMID: 31430964. Pubmed Central PMCID: PMC6784177. Epub 2019/08/23. eng.

Di Domenico EG, Cavallo I, Sivori F, Marchesi F, Prignano G, Pimpinelli F, et al. Biofilm production by Carbapenem-Resistant Klebsiella pneumoniae significantly increases the risk of death in oncological patients. Front Cell Infect Microbiol. 2020;10:561741. PubMed PMID: 33363047. Pubmed Central PMCID: PMC7759150. Epub 2020/12/29. eng.

Article  PubMed  PubMed Central  Google Scholar 

Zhou J, Yang J, Hu F, Gao K, Sun J, Yang J. Clinical and Molecular Epidemiologic Characteristics of Ceftazidime/Avibactam-Resistant carbapenem-resistant Klebsiella pneumoniae in a neonatal intensive care unit in China. Infect drug Resist. 2020;13:2571–8. PubMed PMID: 32801794. Pubmed Central PMCID: PMC7394509. Epub 2020/08/18. eng.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park Y, Choi Q, Kwon GC, Koo SH. Molecular epidemiology and mechanisms of tigecycline resistance in carbapenem-resistant Klebsiella pneumoniae isolates. J Clin Lab Anal. 2020;34(12):e23506. PubMed PMID: 32815626. Pubmed Central PMCID: PMC7755817. Epub 2020/08/21. eng.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rojas LJ, Salim M, Cober E, Richter SS, Perez F, Salata RA, et al. Colistin Resistance in Carbapenem-resistant Klebsiella pneumoniae: Laboratory Detection and Impact on Mortality. Clin Infect Diseases: Official Publication Infect Dis Soc Am. 2017;64(6):711–8. PubMed PMID: 27940944. Pubmed Central PMCID: PMC5850634. Epub 2016/12/13. eng.

CAS  Google Scholar 

Liu L, Feng Y, Tang G, Lin J, Huang W, Qiao F, et al. Carbapenem-resistant isolates of the Klebsiella pneumoniae Complex in Western China: the common ST11 and the Surprising Hospital-specific types. Clin Infect Diseases: Official Publication Infect Dis Soc Am. 2018;67(suppl2):263–S5. PubMed PMID: 30423053. Epub 2018/11/14. eng.

Article  Google Scholar 

Sohrabi M, Alizade Naini M, Rasekhi A, Oloomi M, Moradhaseli F, Ayoub A, et al. Emergence of K1 ST23 and K2 ST65 hypervirulent klebsiella pneumoniae as true pathogens with specific virulence genes in cryptogenic pyogenic liver abscesses Shiraz Iran. Front Cell Infect Microbiol. 2022;12:964290. PubMed PMID: 36017366. Pubmed Central PMCID: PMC9396702. Epub 2022/08/27. eng.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu C, Shi J, Guo J. High prevalence of hypervirulent Klebsiella pneumoniae Infection in the genetic background of elderly patients in two teaching hospitals in China. Infect drug Resist. 2018;11:1031–41. PubMed PMID: 30104891. Pubmed Central PMCID: PMC6074765. Epub 2018/08/15. eng.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dey T, Chakrabortty A, Kapoor A, Warrier A, Nag VL, Sivashanmugam K, et al. Unusual Hypermucoviscous Clinical isolate of Klebsiella pneumoniae with no known determinants of Hypermucoviscosity. Microbiol Spectr. 2022;10(3):e0039322. PubMed PMID: 35647656. Pubmed Central PMCID: PMC9241604. Epub 2022/06/02. eng.

Article  PubMed  Google Scholar 

Hao M, Shi X, Lv J, Niu S, Cheng S, Du H, et al. In vitro activity of Apramycin against Carbapenem-resistant and hypervirulent Klebsiella pneumoniae isolates. Front Microbiol. 2020;11:425. PubMed PMID: 32231657. Pubmed Central PMCID: PMC7083131. Epub 2020/04/02. eng.

Article  PubMed  PubMed Central  Google Scholar 

Fu P, Tang Y, Li G, Yu L, Wang Y, Jiang X. Pandemic spread of bla((KPC-2)) among Klebsiella pneumoniae ST11 in China is associated with horizontal transfer mediated by IncFII-like plasmids. Int J Antimicrob Agents. 2019;54(2):117–24. PubMed PMID: 30885806. Epub 2019/03/20. eng.

Article  CAS 

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