Di Giacomo AM et al (2023) Immunotherapy for brain metastases and primary brain tumors. Eur J Cancer 179:113–120. https://doi.org/10.1016/j.ejca.2022.11.012

Article  PubMed  Google Scholar 

Mo F, Pellerino A, Soffietti R, Ruda R (2021) Blood-brain barrier in Brain tumors: Biology and Clinical Relevance. Int J Mol Sci 22(23):12654. https://doi.org/10.3390/ijms222312654

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cacho-Diaz B, Garcia-Botello DR, Wegman-Ostrosky T, Reyes-Soto G, Ortiz-Sanchez E, Herrera-Montalvo LA (2020) Tumor microenvironment differences between primary Tumor and brain metastases. J Transl Med 18(1):1. https://doi.org/10.1186/s12967-019-02189-8

Article  PubMed  PubMed Central  Google Scholar 

Hynynen K, McDannold N, Vykhodtseva N, Jolesz FA (2001) Noninvasive MR imaging–guided focal opening of the blood-brain barrier in rabbits. Radiology 220(3):640–646. https://doi.org/10.1148/radiol.2202001804

Article  CAS  PubMed  Google Scholar 

Hynynen K, McDannold N, Sheikov NA, Jolesz FA, Vykhodtseva N (2005) Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications. NeuroImage 24(1):12–20. https://doi.org/10.1016/j.neuroimage.2004.06.046

Article  PubMed  Google Scholar 

Cohen-Inbar O, Xu Z, Sheehan JP (2016) Focused ultrasound-aided immunomodulation in Glioblastoma Multiforme: a therapeutic concept. J Ther Ultrasound 4:2. https://doi.org/10.1186/s40349-016-0046-y

Article  PubMed  PubMed Central  Google Scholar 

Yumita N, Nishigaki R, Umemura K, Umemura S (1989) Hematoporphyrin as a sensitizer of cell-damaging effect of ultrasound. Jpn J Cancer Res., 80(3):219 – 22. https://doi.org/10.1111/j.1349-7006.1989.tb02295.x

Zhu L et al (2018) Focused ultrasound-enabled Brain Tumor Liquid Biopsy. Sci Rep 8(1):6553. https://doi.org/10.1038/s41598-018-24516-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patrick JT, Nolting MN, Goss SA, Dines KA, Clendenon JL, Rea MA, Heimburger RF (1990) Ultrasound and the blood-brain barrier. Adv Exp Med Biol 267:369–381. https://doi.org/10.1007/978-1-4684-5766-7_36

Article  CAS  PubMed  Google Scholar 

Elhelf IAS, Albahar H, Shah U, Oto A, Cressman E, Almekkawy M (2018) High intensity focused ultrasound: the fundamentals, clinical applications and research trends. Diagn Interv Imaging 99(6):349–359. https://doi.org/10.1016/j.diii.2018.03.001

Article  PubMed  Google Scholar 

Haar GT, Coussios C (2007) High intensity focused ultrasound: physical principles and devices. Int J Hyperthermia 23(2):89–104. https://doi.org/10.1080/02656730601186138

Article  PubMed  Google Scholar 

Canney MS, Khokhlova VA, Bessonova OV, Bailey MR, Crum LA (2010) Shock-induced heating and millisecond boiling in gels and tissue due to high intensity focused ultrasound. Ultrasound Med Biol 36(2):250–267. https://doi.org/10.1016/j.ultrasmedbio.2009.09.010

Article  PubMed  Google Scholar 

Vykhodtseva NI, Hynynen K, Damianou C (1995) Histologic effects of high intensity pulsed ultrasound exposure with subharmonic emission in rabbit brain in vivo. Ultrasound Med Biol 21(7):969–979. https://doi.org/10.1016/0301-5629(95)00038-s

Article  CAS  PubMed  Google Scholar 

Meng Y et al (2019) Safety and efficacy of focused ultrasound induced blood-brain barrier opening, an integrative review of animal and human studies. J Control Release 309:25–36. https://doi.org/10.1016/j.jconrel.2019.07.023

Article  CAS  PubMed  Google Scholar 

Nance E et al (2014) Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood-brain barrier using MRI-guided focused ultrasound. J Control Release 189:123–132. https://doi.org/10.1016/j.jconrel.2014.06.031

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Y, Alkins R, Schwartz ML, Hynynen K (2017) Opening the blood-brain barrier with MR Imaging-guided focused Ultrasound: preclinical testing on a trans-human Skull Porcine Model. Radiology 282(1):123–130. https://doi.org/10.1148/radiol.2016152154

Article  PubMed  Google Scholar 

Wang S, Samiotaki G, Olumolade O, Feshitan JA, Konofagou EE (2014) Microbubble type and distribution dependence of focused ultrasound-induced blood-brain barrier opening. Ultrasound Med Biol 130–137. https://doi.org/10.1016/j.ultrasmedbio.2013.09.015

SK, Wu et al (2017) Characterization of different microbubbles in assisting focused Ultrasound-Induced blood-brain barrier opening. Sci Rep 7:46689. https://doi.org/10.1038/srep46689

Article  CAS  Google Scholar 

McMahon D, O’Reilly MA, Hynynen K (2021) Therapeutic Agent Delivery across the blood-brain barrier using focused Ultrasound. Annu Rev Biomed Eng 23:89–113. https://doi.org/10.1146/annurev-bioeng-062117-121238

Article  CAS  PubMed  Google Scholar 

Liu HL et al (2008) Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging. Ultrasound Med Biol 34(4):598–606. https://doi.org/10.1016/j.ultrasmedbio.2008.01.011

Article  PubMed  Google Scholar 

Anastasiadis P et al (2021) Localized blood-brain barrier opening in infiltrating gliomas with MRI-guided acoustic emissions-controlled focused ultrasound. Proc Natl Acad Sci U S A 118(37):e2103280118. https://doi.org/10.1073/pnas.2103280118

Article  CAS  PubMed  PubMed Central  Google Scholar 

KT, Chen et al (2020) Neuronavigation-guided focused ultrasound (NaviFUS) for transcranial blood-brain barrier opening in recurrent glioblastoma patients: clinical trial protocol. Ann Transl Med 8(11):673. https://doi.org/10.21037/atm-20-344

Article  Google Scholar 

KT, Chen et al (2021) Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors. Sci Adv 7(6):eabd0772. https://doi.org/10.1126/sciadv.abd0772

Article  CAS  Google Scholar 

Carpentier A et al (2016) Clinical trial of blood-brain barrier disruption by pulsed ultrasound. Sci Transl Med 8(343):343re2. https://doi.org/10.1126/scitranslmed.aaf6086

Article  CAS  PubMed  Google Scholar 

Yonemori K et al (2010) Disruption of the blood brain barrier by brain metastases of triple-negative and basal-type Breast cancer but not HER2/neu-positive Breast cancer. Cancer 116(2):302–308. https://doi.org/10.1002/cncr.24735

Article  PubMed  Google Scholar 

Lipsman N et al (2018) Blood-brain barrier opening in Alzheimer’s Disease using MR-guided focused ultrasound. Nat Commun 9(1):2336. https://doi.org/10.1038/s41467-018-04529-6

Article  CAS  PubMed  Google Scholar 

Meng Y et al (2021) MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases. Sci Transl Med 13(615):eabj4011. https://doi.org/10.1126/scitranslmed.abj4011

Article  CAS  PubMed  Google Scholar 

Park SH et al (2020) One-year outcome of multiple blood-brain barrier disruptions with Temozolomide for the treatment of Glioblastoma. Front Oncol 10:1663. https://doi.org/10.3389/fonc.2020.01663

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahluwalia MS, Becker K, Levy BP (2018) Epidermal growth factor receptor tyrosine kinase inhibitors for Central Nervous System metastases from Non-small Cell Lung Cancer. Oncologist 23(10):1199–1209. https://doi.org/10.1634/theoncologist.2017-0572

Article  CAS  PubMed  PubMed Central  Google Scholar 

Treat LH, McDannold N, Vykhodtseva N, Zhang Y, Tam K, Hynynen K (2007) Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound. Int J Cancer 121(4):901–907. https://doi.org/10.1002/ijc.22732

Article  CAS  PubMed  Google Scholar 

Treat LH, McDannold N, Zhang Y, Vykhodtseva N, Hynynen K (2012) Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma. Ultrasound Med Biol 38(10):1716–1725. https://doi.org/10.1016/j.ultrasmedbio.2012.04.015

Article  PubMed  PubMed Central  Google Scholar 

Aryal M, Vykhodtseva N, Zhang YZ, McDannold N (2015) Multiple sessions of liposomal doxorubicin delivery via focused ultrasound mediated blood-brain barrier disruption: a safety study. J Control Release 204:60–69. https://doi.org/10.1016/j.jconrel.2015.02.033

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kinoshita M, McDannold N, Jolesz FA, Hynynen K (2006) Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Proc Natl Acad Sci U S A 103(31):11719–11723. https://doi.org/10.1073/pnas.0604318103

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park EJ, Zhang YZ, Vykhodtseva N, McDannold N (2012) Ultrasound-mediated blood-brain/blood-tumor barrier disruption improves outcomes with trastuzumab in a Breast cancer brain Metastasis model. J Control Release 163(3):277–284. https://doi.org/10.1016/j.jconrel.2012.09.007

Article  CAS  PubMed  PubMed Central  Google Scholar 

HL, Liu et al (2016) Focused Ultrasound enhances Central Nervous System Delivery of Bevacizumab for malignant glioma treatment. Radiology 281(1):99–108. https://doi.org/10.1148/radiol.2016152444