Positive association between increased homocysteine and deficit syndrome in Chinese patients with chronic schizophrenia: a large-scale cross-sectional study

López-Díaz Á, Menéndez-Sampil C, Pérez-Romero A et al (2020) Characterization of deficit schizophrenia and reliability of the bidimensional model of its negative symptomatology. Nord J Psychiatry 74:400–406. https://doi.org/10.1080/08039488.2020.1736151

Article  PubMed  Google Scholar 

Bora E, Binnur Akdede B, Alptekin K (2017) Neurocognitive impairment in deficit and non-deficit schizophrenia: a meta-analysis. Psychol Med 47:2401–2413. https://doi.org/10.1017/S0033291717000952

Article  CAS  PubMed  Google Scholar 

Zhu X, Chen D, Xiu M et al (2022) Serum BDNF levels, glycolipid metabolism in deficit schizophrenia: a case-control study. Asian J Psychiatry 69:103003. https://doi.org/10.1016/j.ajp.2022.103003

Article  Google Scholar 

López-Díaz Á, Lara I, Lahera G (2018) Is the prevalence of the deficit syndrome in schizophrenia higher than estimated? Results of a meta-analysis. Psychiatry Investig 15:94–98. https://doi.org/10.4306/pi.2018.15.1.94

Article  PubMed  PubMed Central  Google Scholar 

Strauss GP, Harrow M, Grossman LS, Rosen C (2010) Periods of recovery in deficit syndrome schizophrenia: a 20-year multi-follow-up longitudinal study. Schizophr Bull 36:788–799. https://doi.org/10.1093/schbul/sbn167

Article  PubMed  Google Scholar 

Liu J, Tian Y, Wei S et al (2022) Association of empathy with clinical symptoms and cognitive function in Chinese chronic schizophrenia patients with and without deficit syndrome. Prog Neuropsychopharmacol Biol Psychiatry 119:110592. https://doi.org/10.1016/j.pnpbp.2022.110592

Article  PubMed  Google Scholar 

Sum MY, Tay KH, Sengupta S, Sim K (2018) Neurocognitive functioning and quality of life in patients with and without deficit syndrome of schizophrenia. Psychiatry Res 263:54–60. https://doi.org/10.1016/j.psychres.2018.02.025

Article  PubMed  Google Scholar 

Köşger F, Yiğitaslan S, Eşsizoğlu A et al (2020) Inflammation and oxidative stress in deficit schizophrenia. Noro Psikiyatr Ars 57:303–307. https://doi.org/10.29399/npa.24966

Article  PubMed  PubMed Central  Google Scholar 

Maes M, Sirivichayakul S, Matsumoto AK et al (2020) Lowered antioxidant defenses and increased oxidative toxicity are hallmarks of deficit schizophrenia: a nomothetic network psychiatry approach. Mol Neurobiol 57:4578–4597. https://doi.org/10.1007/s12035-020-02047-5

Article  CAS  PubMed  Google Scholar 

Albayrak Y, Ünsal C, Beyazyüz M et al (2013) Reduced total antioxidant level and increased oxidative stress in patients with deficit schizophrenia: a preliminary study. Prog Neuropsychopharmacol Biol Psychiatry 45:144–149. https://doi.org/10.1016/j.pnpbp.2013.04.020

Article  CAS  PubMed  Google Scholar 

Maes M, Kanchanatawan B, Sirivichayakul S, Carvalho AF (2019) In schizophrenia, deficits in natural IgM isotype antibodies including those directed to malondialdehyde and azelaic acid strongly predict negative symptoms, neurocognitive impairments, and the deficit syndrome. Mol Neurobiol 56:5122–5135. https://doi.org/10.1007/s12035-018-1437-6

Article  CAS  PubMed  Google Scholar 

Karolczak K, Watala C (2021) Melatonin as a reducer of neuro- and vasculotoxic oxidative stress induced by homocysteine. Antioxidants (Basel) 10:1178. https://doi.org/10.3390/antiox10081178

Article  CAS  PubMed  Google Scholar 

Yang M, Zhou X, Tan X et al (2022) The status of oxidative stress in patients with alcohol dependence: a meta-analysis. Antioxidants (Basel) 11:1919. https://doi.org/10.3390/antiox11101919

Article  CAS  PubMed  Google Scholar 

Ma YY, Shek CC, Wong MC et al (2009) Homocysteine level in schizophrenia patients. Aust N Z J Psychiatry 43:760–765. https://doi.org/10.1080/00048670903001935

Article  PubMed  Google Scholar 

Yang Y, Wang J, Xiong Z et al (2021) Prevalence and clinical demography of hyperhomocysteinemia in Han Chinese patients with schizophrenia. Eur Arch Psychiatry Clin Neurosci 271:759–765. https://doi.org/10.1007/s00406-020-01150-x

Article  PubMed  Google Scholar 

Fraguas D, Díaz-Caneja CM, Ayora M et al (2019) Oxidative stress and inflammation in first-episode psychosis: a systematic review and meta-analysis. Schizophr Bull 45:742–751. https://doi.org/10.1093/schbul/sby125

Article  PubMed  Google Scholar 

Ermakov EA, Dmitrieva EM, Parshukova DA et al (2021) Oxidative stress-related mechanisms in schizophrenia pathogenesis and new treatment perspectives. Oxid Med Cell Longev 2021:8881770. https://doi.org/10.1155/2021/8881770

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang X, Yang H, Li N et al (2022) Increased serum homocysteine in first episode and drug-naïve individuals with schizophrenia: sex differences and correlations with clinical symptoms. BMC Psychiatry 22:759. https://doi.org/10.1186/s12888-022-04416-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trześniowska-Drukała B, Kalinowska S, Safranow K et al (2019) Evaluation of hyperhomocysteinemia prevalence and its influence on the selected cognitive functions in patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 95:109679. https://doi.org/10.1016/j.pnpbp.2019.109679

Article  CAS  PubMed  Google Scholar 

Regland B, Johansson BV, Grenfeldt B et al (1995) Homocysteinemia is a common feature of schizophrenia. J Neural Transm 100:165–169. https://doi.org/10.1007/BF01271539

Article  CAS  Google Scholar 

Zhou S, Huang Y, Feng Y et al (2021) Association between plasma homocysteine levels and cognitive deficits in Han Chinese patients with schizophrenia across age groups. Sci Rep 11:19716. https://doi.org/10.1038/s41598-021-99239-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li H, Li H, Zhu Z et al (2023) Association of serum homocysteine levels with intestinal flora and cognitive function in schizophrenia. J Psychiatr Res 159:258–265. https://doi.org/10.1016/j.jpsychires.2023.01.045

Article  PubMed  Google Scholar 

Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13:261–276. https://doi.org/10.1093/schbul/13.2.261

Article  CAS  PubMed  Google Scholar 

Goetz RR, Corcoran C, Yale S et al (2007) Validity of a “proxy” for the deficit syndrome derived from the Positive And Negative Syndrome Scale (PANSS). Schizophr Res 93:169–177. https://doi.org/10.1016/j.schres.2007.02.018

Article  PubMed  PubMed Central  Google Scholar 

Huang Y, Wu K, Li H et al (2020) Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia. Sci Rep 10:16119. https://doi.org/10.1038/s41598-020-72934-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang B, Fan S, Zhi X et al (2014) Prevalence of hyperhomocysteinemia in China: a systematic review and meta-analysis. Nutrients 7:74–90. https://doi.org/10.3390/nu7010074

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou Y, Peng P, Yuan N et al (2023) Suicidal ideation in Chinese patients with chronic schizophrenia: prevalence, clinical correlates, and relationship with alexithymia. Eur Arch Psychiatry Clin Neurosci. https://doi.org/10.1007/s00406-023-01630-w

Article  PubMed  Google Scholar 

Peng P, Wang Q, Ren H et al (2023) Association between thyroid hormones and comorbid psychotic symptoms in patients with first-episode and drug-naïve major depressive disorder. Psychiatry Res 320:115052. https://doi.org/10.1016/j.psychres.2023.115052

Article  CAS  PubMed  Google Scholar 

Peng P, Wang Q, Zhou Y et al (2023) Association of subclinical hypothyroidism with metabolic syndrome and its components among outpatients with first-episode drug-naïve major depressive disorder: a large-scale cross-sectional study. Eur Arch Psychiatry Clin Neurosci. https://doi.org/10.1007/s00406-023-01588-9

Article  PubMed  Google Scholar 

Liu J, Wang D, Zhou H et al (2021) Deficit syndrome in Chinese patients with first-episode drug naïve schizophrenia: prevalence, demographic and clinical characteristics. Asian J Psychiatr 65:102861. https://doi.org/10.1016/j.ajp.2021.102861

Article  PubMed  Google Scholar 

Liu J, He J, Cheng M et al (2019) Prevalence, sociodemographic, and clinical correlates of older Chinese patients with deficit schizophrenia. J Geriatr Psychiatry Neurol 32:298–303. https://doi.org/10.1177/0891988719870321

Article  PubMed  Google Scholar 

Yu J, Xue R, Wang Q et al (2022) The effects of plasma homocysteine level on the risk of three major psychiatric disorders: a Mendelian randomization study. Front Psychiatry 13:841429. https://doi.org/10.3389/fpsyt.2022.841429

Article  PubMed  PubMed Central  Google Scholar 

Al-Kuraishy HM, Al-Gareeb AI, Elewa YHA et al (2023) Parkinson’s disease risk and hyperhomocysteinemia: the possible link. Cell Mol Neurobiol. https://doi.org/10.1007/s10571-023-01350-8

Article  PubMed  PubMed Central  Google Scholar 

Bhatia P, Singh N (2015) Homocysteine excess: delineating the possible mechanism of neurotoxicity and depression. Fundam Clin Pharmacol 29:522–528. https://doi.org/10.1111/fcp.12145

Article  CAS  PubMed 

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