Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan (Y.S., M.K., M.M., N.M., N.H., M.H.); Advanced Research Center for Innovations in Next-Generation Medicine (E.H., A.U., S.S., K.K., M.M., N.H., M.H.), Tohoku Medical Megabank Organization (E.H., S.S., S.T., K.K., M.H.), and Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences (S.Y., M.K., N.H., M.H.), Tohoku University, Sendai, Japan; Graduate School of Information Sciences, Hiroshima City University, Hiroshima, Japan (T.N.); and Department of Biophysical Chemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan (A.O.)