Albini A, Soldi R, Giunciuglio D, Giraudo E, Benelli R, Primo L, Noonan D, Salio M, Camussi G, Rockl W, Bussolino F (1996) The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells. Nat Med 2:1371–1375

Article  CAS  PubMed  Google Scholar 

Amin-Wetzel N, Neidhardt L, Yan Y, Mayer MP, Ron D (2019) Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR. Elife 8

An J, Harms C, Lattig-Tunnemann G, Sellge G, Mandic AD, Malato Y, Heuser A, Endres M, Trautwein C, Donath S (2012) TAT-apoptosis repressor with caspase recruitment domain protein transduction rescues mice from fulminant liver failure. Hepatology 56:715–726

Article  CAS  PubMed  Google Scholar 

András IE, Pu H, Deli MA, Nath A, Hennig B, Toborek M (2003) HIV-1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells. J Neurosci Res 74:255–265

Article  PubMed  Google Scholar 

Andras IE, Pu H, Tian J, Deli MA, Nath A, Hennig B, Toborek M (2005) Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells. J Cereb Blood Flow Metab 25:1159–1170

Article  CAS  PubMed  Google Scholar 

Andras IE, Toborek M (2011) HIV-1-induced alterations of claudin-5 expression at the blood-brain barrier level. Methods Mol Biol 762:355–370

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bozzelli PL, Yin T, Avdoshina V, Mocchetti I, Conant KE, Maguire-Zeiss KA (2019) HIV-1 Tat promotes astrocytic release of CCL2 through MMP/PAR-1 signaling. Glia 67:1719–1729

Article  PubMed  PubMed Central  Google Scholar 

Chandra PK, Rutkai I, Kim H, Braun SE, Abdel-Mageed AB, Mondal D, Busija DW (2021) Latent HIV-exosomes induce mitochondrial hyperfusion due to loss of phosphorylated dynamin-related protein 1 in brain endothelium. Mol Neurobiol 58:2974–2989

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Q, Wu Y, Yu Y, Wei J, Huang W (2021) Rho-kinase inhibitor hydroxyfasudil protects against HIV-1 Tat-induced dysfunction of tight junction and neprilysin/Abeta transfer receptor expression in mouse brain microvessels. Mol Cell Biochem 476:2159–2170

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chivero ET, Guo ML, Periyasamy P, Liao K, Callen SE, Buch S (2017) HIV-1 Tat primes and activates microglial NLRP3 inflammasome-mediated neuroinflammation. J Neurosci 37:3599–3609

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clifford DB, Ances BM (2013) HIV-associated neurocognitive disorder. Lancet Infect Dis 13:976–986

Article  PubMed  PubMed Central  Google Scholar 

Conant K, St Hillaire C, Anderson C, Galey D, Wang J, Nath A (2004) Human immunodeficiency virus type 1 Tat and methamphetamine affect the release and activation of matrix-degrading proteinases. J Neurovirol 10:21–28

Article  CAS  PubMed  Google Scholar 

Cota-Gomez A, Flores NC, Cruz C, Casullo A, Aw TY, Ichikawa H, Schaack J, Scheinman R, Flores SC (2002) The human immunodeficiency virus-1 Tat protein activates human umbilical vein endothelial cell E-selectin expression via an NF-kappa B-dependent mechanism. J Biol Chem 277:14390–14399

Article  CAS  PubMed  Google Scholar 

Cozac VV, Gschwandtner U, Hatz F, Hardmeier M, Ruegg S, Fuhr P (2016) Quantitative EEG and cognitive decline in Parkinson’s disease. Parkinsons Dis 2016:9060649

PubMed  PubMed Central  Google Scholar 

Crockett AM, Ryan SK, Vasquez AH, Canning C, Kanyuch N, Kebir H, Ceja G, Gesualdi J, Zackai E, McDonald-McGinn D, Viaene A, Kapoor R, Benallegue N, Gur R, Anderson SA, Alvarez JI (2021) Disruption of the blood-brain barrier in 22q11.2 deletion syndrome. Brain 144:1351–1360

Article  PubMed  PubMed Central  Google Scholar 

D’Aversa TG, Yu KO, Berman JW (2004) Expression of chemokines by human fetal microglia after treatment with the human immunodeficiency virus type 1 protein Tat. J Neurovirol 10:86–97

Article  CAS  PubMed  Google Scholar 

da Silva EF, Fonseca FA, França CN, Ferreira PR, Izar MC, Salomão R, Camargo LM, Tenore SB, Lewi DS (2011) Imbalance between endothelial progenitors cells and microparticles in HIV-infected patients naive for antiretroviral therapy. AIDS 25:1595–1601

Article  PubMed  Google Scholar 

Dagur RS, Liao K, Sil S, Niu F, Sun Z, Lyubchenko YL, Peeples ES, Hu G, Buch S (2020) Neuronal-derived extracellular vesicles are enriched in the brain and serum of HIV-1 transgenic rats. J Extracell Vesicles 9:1703249

Dai H, Shen K, Yang Y, Su X, Luo Y, Jiang Y, Shuai L, Zheng P, Chen Z, Bie P (2019) PUM1 knockdown prevents tumor progression by activating the PERK/eIF2/ATF4 signaling pathway in pancreatic adenocarcinoma cells. Cell Death Dis 10:595

Article  PubMed  PubMed Central  Google Scholar 

Debalkie Animut M, Sorrie MB, Birhanu YW, Teshale MY (2019) High prevalence of neurocognitive disorders observed among adult people living with HIV/AIDS in Southern Ethiopia: A cross-sectional study. PLoS ONE 14:e0204636

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duan S, Neary JT (2006) P2X(7) receptors: properties and relevance to CNS function. Glia 54:738–746

Article  PubMed  Google Scholar 

El-Hage N, Bruce-Keller AJ, Knapp PE, Hauser KF (2008a) CCL5/RANTES gene deletion attenuates opioid-induced increases in glial CCL2/MCP-1 immunoreactivity and activation in HIV-1 Tat-exposed mice. J Neuroimmune Pharmacol 3:275–285

Article  PubMed  PubMed Central  Google Scholar 

El-Hage N, Bruce-Keller AJ, Yakovleva T, Bazov I, Bakalkin G, Knapp PE, Hauser KF (2008b) Morphine exacerbates HIV-1 Tat-induced cytokine production in astrocytes through convergent effects on [Ca(2+)](i). NF-kappaB Trafficking and Transcription Plos One 3:e4093

PubMed  Google Scholar 

Fan Y, He JJ (2016) HIV-1 Tat induces unfolded protein response and endoplasmic reticulum stress in astrocytes and causes neurotoxicity through glial fibrillary acidic protein (GFAP) activation and aggregation. J Biol Chem 291:22819–22829

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farhadian SF, Lindenbaum O, Zhao J, Corley MJ, Im Y, Walsh H, Vecchio A, Garcia-Milian R, Chiarella J, Chintanaphol M, Calvi R, Wang G, Ndhlovu LC, Yoon J, Trotta D, Ma S, Kluger Y, Spudich S (2022) HIV viral transcription and immune perturbations in the CNS of people with HIV despite ART. JCI Insight 7

Gandhi N, Saiyed ZM, Napuri J, Samikkannu T, Reddy PV, Agudelo M, Khatavkar P, Saxena SK, Nair MP (2010) Interactive role of human immunodeficiency virus type 1 (HIV-1) clade-specific Tat protein and cocaine in blood-brain barrier dysfunction: implications for HIV-1-associated neurocognitive disorder. J Neurovirol 16:294–305

Article  CAS  PubMed  Google Scholar 

Gloire G, Legrand-Poels S, Piette J (2006) NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 72:1493–1505

Article  CAS  PubMed  Google Scholar 

Goldstein G, Damiano E, Donikyan M, Pasha M, Beckwith E, Chicca J (2012) HIV-1 Tat B-cell epitope vaccination was ineffectual in preventing viral rebound after ART cessation: HIV rebound with current ART appears to be due to infection with new endogenous founder virus and not to resurgence of pre-existing Tat-dependent viremia. Hum Vaccin Immunother 8:1425–1430

Article  PubMed  PubMed Central  Google Scholar 

Graziano F, Desdouits M, Garzetti L, Podini P, Alfano M, Rubartelli A, Furlan R, Benaroch P, Poli G (2015) Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages. Proc Natl Acad Sci U S A 112:E3265–E3273

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gupta S, Knight AG, Gupta S, Knapp PE, Hauser KF, Keller JN, Bruce-Keller AJ (2010) HIV-Tat elicits microglial glutamate release: role of NAPDH oxidase and the cystine-glutamate antiporter. Neurosci Lett 485:233–236

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D (2000) Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 6:1099–1108

Article  CAS  PubMed  Google Scholar 

Hawkins BT, Davis TP (2005) The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev 57:173–185

Article  CAS  PubMed  Google Scholar 

Henderson LJ, Johnson TP, Smith BR, Reoma LB, Santamaria UA, Bachani M, Demarino C, Barclay RA, Snow J, Sacktor N, McArthur J, Letendre S, Steiner J, Kashanchi F, Nath A (2019) Presence of Tat and transactivation response element in spinal fluid despite antiretroviral therapy. Aids 33(Suppl 2):S145–S157

Article  CAS  PubMed  Google Scholar 

Huang J, Zhang R, Wang S, Zhang D, Leung CK, Yang G, Li Y, Liu L, Xu Y, Lin S, Wang C, Zeng X, Li J (2021) Methamphetamine and HIV-Tat protein synergistically induce oxidative stress and blood-brain barrier damage via transient receptor potential melastatin 2 channel. Front Pharmacol 12:619436

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang W, Rha GB, Chen L, Seelbach MJ, Zhang B, Andras IE, Bruemmer D, Hennig B, Toborek M (2010) Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells. Am J Physiol Heart Circ Physiol 298:H1136–H1145

Article  CAS  PubMed  PubMed Central  Google Scholar 

Illes P (2020) P2X7 Receptors amplify CNS damage in neurodegenerative diseases. Int J Mol Sci 21

Jadhav S, Nema V (2021) HIV-associated neurotoxicity: the interplay of host and viral proteins. Mediators Inflamm 2021:1267041

Article  PubMed  PubMed Central  Google Scholar